|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Development and verification of a one-dimensional ablation code including pyrolysis gas flow 显示文摘 | Amar A J Blackwell B F Edwards J R | 2009 | Journal of Thermophysics and Heat Transfer2009，23，1： | 1 |
| 3 | A review of lat- est research findings on the health promotion properties of tea 显示文摘 | Christiane J D Edward R F | 2001 | Journal of Nutritional Biochemistry2001，12，： | 1 |
| 4 | Futures trading and cash market volatility: Stock index and interest rate fu-tures显示文摘 | Edwards F R | 1988 | Journal of futures markets1988，8，4： | 1 |
| 5 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 6 | Viral metagenomics显示文摘 | Edwards R A Rohwer F | 2005 | Nature2005，3，： | 1 |
| 7 | Structural Characterization of the Released Polysaccharide of Desiccation-Tolerant Nostoc commune DRH-1 显示文摘 | Helm R F Huang Z B Edwards D | 2000 | J Bact2000，182，4： | 1 |
| 8 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
| 9 | Small-Angle Neutron Scattering From a Polystyrene-b-Poly (methyl methacrylate) Diblock Copolymer in a Selective Solvent显示文摘 | Edwards C J C Richards R W Stepto R F T | 1986 | Polymer1986，27，5： | 1 |
| 10 | A glimpse into the expanded genome content of Vibrio cholerae through identification of genes present in environmental strains显示文摘 | Purdy A Rohwer F Edwards R | 2005 | J Bacteriol2005，187，9： | 1 |
| 11 | Fecal coliform and strep- tococcus concentrations in runoff from grazed pastures in Northwest Arkansas显示文摘 | Edwards D R Coyne M S Vendrell P F | 1997 | Jawra Journal of the American Water Resources Associa- tion1997，33，2： | 1 |
| 12 | Gastrointestinal symptoms in Parkinson's disease 显示文摘 | Edwards L L Pfeiffer R F Quigley E M | 1991 | Mov Disord1991，6，： | 1 |
| 13 | Activation of blood coagulation in cancer: Trousseau's syndrome revisited显示文摘 | RICKLES F R EDWARDS R L | | Blood0，62，1： | 1 |
| 14 | Structural characterization of the released polysaccharide of desiccation-tolerant Nostoc commune DRH- 1 显示文摘 | Helm R F Huang Z Edwards D | 2000 | J Bacteriol12000，182，： | 1 |
| 15 | Changes in the epidemiology of methicillin resist- ant staphylococcus aureus in intensive units in us hos- pitals 1992-2003显示文摘 | KLEVENS R M EDWARDS J R TENOVER F C | 2006 | Clin Infect Dis2006，42，： | 1 |
| 16 | Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice显示文摘 | Zhang Y Schlossman S F Edwards R A Ou C N Gu J Wu M X | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 17 | Development and verification of a one-dimensional ablation code including py- rolysis gas flow 显示文摘 | Amar A J Blackwell B F Edwards J R | 2009 | Journal of Thermophysics and Heat Transfer2009，23，1： | 1 |
| 18 | Theory of powders显示文摘 | Edwards S F Oakeshott R B S | 1989 | Physica A1989，157，： | 1 |
| 19 | One-dimensional ablation using a full Newton’s method and finite control volume procedure显示文摘 | AMAR A J BLACKWELL B F EDWARDS J R | 2008 | Journal of Thermophysics and Heat transfer2008，22，1： | 1 |
| 20 | Granular antropy: explicit, calculations for planar assemblies显示文摘 | Blumenfeld R Edwards S F | 2003 | Phys Rev Lett2003，90，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员