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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | A biomarker panel for peripheral arterial disease显示文摘 | Fung E T Wilson A M Zhang F Harris N Edwards K A Olin J W | 2008 | Vasc Med2008，13，： | 1 |
| 3 | Event-related potential studies of attention 显示文摘 | Luck Steven J Woodman Geoffrey F Vogel Edward K | 2000 | Trends in Cognitive Sciences2000，4，11： | 1 |
| 4 | Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production 显示文摘 | Martin A Lee J Kichey T Gerentes D Zivy M Tatout C Dubois F Balliau T Valot B Davanture M Laforgue T T Quillere I Coque M Gallais A Moro M B G Bethencourt L Habash D Z Lea P J Charcosset A Perez P Murigneux A Sakakibara H Edwards K J Hirel B | 2006 | The Plant Cell2006，18，11： | 1 |
| 5 | Diffusion-weighted imaging of the prostate and rectal wall: comparison of hiexponential and monoexponential modelled diffusion and associated perfusion coefficients显示文摘 | Riches S F Hawtin K Charles Edwards E M | 2009 | NMR Biomed2009，22，3： | 1 |
| 6 | A numerical study of the measurement of elongational viscosity of polymeric fluids in a semihyperbolically converging die显示文摘 | Feigl K Tanner X F Edwards B J | 2003 | Journal of Non- Newtonian Fluid Mechanics2003，115，23： | 1 |
| 7 | Making Sense of the Legender Transform 显示文摘 | Zia R K P Edward F Redish Susan R McKay | 2009 | Am J Phys2009，77，7： | 1 |
| 8 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 9 | Rapid sea-level fall and deep-ocean temperature change since the last interglacial period 显示文摘 | Cutler K B Edwards R L Yatlor F W | 2003 | Earth Planet Sei Lett2003，206，： | 1 |
| 10 | Calculation of Unsteady Flows in Turbomachinery Using the Linearized Euler Equations显示文摘 | Hall K C Crawley Edward F | 1989 | MAA Journal1989，27，6： | 1 |
| 11 | A newdouble-responsive block copolymer synthesized via RAFTpolymerization: poly ( N-isopropylacrylamide ) -block-poly(acrylic acid) 显示文摘 | Schilli C M Zhang M F Rizzardo E Thang S H ChongY K Edwards K Karlsson G Muller A H E | 2004 | Macromolecules2004，37，21： | 1 |
| 12 | High pressure, quasi-isentropic compression experiments on the Omega laser显示文摘 | Lorenz K T Edwards M J Jankowski A F | 2006 | High Energy Density Physics2006，2，3： | 1 |
| 13 | Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy 显示文摘 | ANNEBETH E F EDWARD F K DOERTHE A L | 2008 | Allergy Clin Immunol2008，121，3： | 1 |
| 14 | A low voltage CMOS bandgap reference without using an Opamp显示文摘 | EDWARD K F L | | 0，，1： | 1 |
| 15 | Auto amputation of the foot caused by untreated gas gangrene: A case report显示文摘 | Barry F Ravi K Edward F | 2003 | The Journal of Foot Ankle Surgery2003，42，6： | 1 |
| 16 | A 1-V 8-bit successive approximation ADC in standard CMOS process显示文摘 | Siamak Mortezapour Edward K F Lee | 2000 | IEEE Journal of Solid-State Circuits2000，35，4： | 1 |
| 17 | The effective- ness of several commercial antifouling treatments at reducing biofouling on finfish aquaculture cages in British Columbia 显示文摘 | EDWARDS C D PAWLUK K A CROSS S F | 2015 | Aquaculture Research2015，46，9： | 1 |
| 18 | 显示文摘 | Edwards S F | 1989 | J Chem Phys1989，90，： | 1 |
| 19 | A test of climate, sun, and culture relationships from an 1810-year Chinese cave record显示文摘 | Zhang P Z Cheng H Edwards R L Chen F H Wang Y J Yang X L Liu J Tan M Wang X F Liu J H An C L Dai Z B Zhou J Zhang D Z Jia J H Jin L Y Johnson K R | 2008 | Science2008，322，5903： | 1 |
| 20 | The incidence of contact lens-related microbial keratitis in Australia 显示文摘 | Stapleton F Keay L Edwards K | 2008 | Ophthalmology2008，115，10： | 1 |
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