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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Recurrent ectopic pancreatitis of the jejunum and mesentery over a 30-year period显示文摘BACKGROUND:Ectopic pancreas is defined as pancreatic tissue found outside its usual anatomical position,with no ductal or vascular communication with the native pancreas. We describe a case of ectopic pancreas of the small bowel and mesentery causing recurrent episodes of pancreatitis, initially suspected on computed tomography(CT)and magnetic resonance cholangiopancreatography(MRCP),and confirmed on histological review of the resection. METHODS:A 67-year-old woman presented with clinical symptoms and biochemical evidence of pancreatitis.She had similar episodes over the past 30 years with unrevealing investigations,and was concluded to have idiopathic pancreatitis. She underwent CT and MRCP,with findings suggestive of ectopic pancreas,a diagnosis confirmed on histology of the resection. RESULTS:MRCP identified a mass in the proximal small bowel mesentery isointense to the native pancreas,with a small duct draining into a proximal jejunal loop.The resected specimen consisted of normal parenchyma with lobulated acinar tissue with scattered islets of Langerhans,an occasional ductular structure,and admixed areas of adipose tissue.The patient remained asymptomatic with normal biochemistry six months post-operatively. CONCLUSION:In an individual with abdominal pain,elevated serum amylase/lipase,but imaging findings of a normal native pancreas,ectopic pancreatitis should be considered,and can be evaluated by CT and MRCP. | John CT Wong Charlotte Robinson Edward C Jones Alison Harris Charles Zwirewich Robert Wakefield Richard K Simons Eric M Yoshida | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 4 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | p57, structurally distinct member is a candidate tumor suppressor gene 显示文摘 | Matsuoka M Edwards MC Bai C | 1995 | Genes Der1995，9，6： | 2 |
| 5 | Glucocorticoid-induced,caspase-dependent organ apoptosis early after burn injury显示文摘 | EDWARDS C CLARE-SALZLER M | 2000 | Am J Physiol Regul Integr Comp Physiol2000，278，4： | 1 |
| 6 | A method for analyzing plant architecture as it relates to fruit qualibty using three-dimensional computer graphics显示文摘 | Smith G S Curtis J P Edwards C M | 1992 | Annals of Botany1992，70，： | 1 |
| 7 | The management of traumatic spondylolisthesis of the axis 显示文摘 | Levine A M Edwards C C | 1985 | J Bone joint Surg (Am)1985，67，： | 1 |
| 8 | Simple sequence repeat(SSR)marker survey of the cassava(Manihot esculenta Crantz)genome:toward a SSR-based molecular genetic map of cassava显示文摘 | Mba R E C Stephenson P Edwards K Mezer S Nkumbira J Gulberg U Apel K Gale M Tohme J Fregene M A | | 0，，： | 1 |
| 9 | Weld ability and hot ductility of chromium- modified Ni3A1 alloys 显示文摘 | Maguire M C Edwards G R David S A | 1992 | Weldin: Iournal1992，71，7： | 1 |
| 10 | Fractures of the distal clavicle:a case for fixation显示文摘 | EDWARDS D J KAVANAGH T G FLANNERY M C | 1992 | Injury1992，23，： | 1 |
| 11 | Evidence that the alpha a gene of Barley stripe mosaic virus encodes determinants of pathogenicity to oat (Avena saliva)显示文摘 | Weiland J J Edwards M C | 1994 | Virology1994，201，1： | 1 |
| 12 | Characteristic macropores that affect infiltration into nontilled soil显示文摘 | Edwards W M Norton L D Redmond C E | 1988 | Soil Science Society of America Journal1988，52，2： | 1 |
| 13 | Combination cone penetration resistance/water content instrumentation to evaluate cone penetration-water content relationships in tillage research显示文摘 | Lapen D R Topp G C Edwards M E | 2004 | Soil and Tillage Research2004，79，1： | 1 |
| 14 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 15 | Laboratory calibration,in-field validation and use of a soil penetrometer measuring cone resistance and water content显示文摘 | Topp G C Lapen D R Edwards M J | 2003 | Vadose Zone Journal2003，2，4： | 1 |
| 16 | Freezing and its effects on chemical and biological properties of soil 显示文摘 | EDWARDS A C CRESSER M S | 1992 | Advances in Soil Sciences1992，18，： | 1 |
| 17 | Effect of dietary fat and cholesterol on the in vitro incorporation of acetate-14C into hen liver and ovarian lipids 显示文摘 | JOSEPH F W EDWARD C N RALPH M J | 1967 | The Journal of Nutrition1967，93，： | 1 |
| 18 | High performanceliquid chromatographic analysis of lactose-hydrolysed milk显示文摘 | INDYK H E EDWARDS M J WOOLLARDB D C | 1996 | FoodChemistry1996，57，4： | 1 |
| 19 | Infrared spectroscopic analyses on the nature of water in montmorillonite显示文摘 | BISHOP J L PIETERS C M EDWARDS J O | 1994 | Clays Clay Miner1994，42，： | 1 |
| 20 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
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