|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Cancer stem cell plasticity and tumor hierarchy显示文摘The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer. | Marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 3 | Predictors of outcome following hip fracture. Admission time predicts length of stay and in-hospital mortality显示文摘 | John E Clague Elaine Craddock Glynn Andrew Michael A Horan Neil Pendleton | 2002 | Injury2002，，1： | 2 |
| 4 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 5 | Boerhaave's syndrome: a review ofmanagement and outcome 显示文摘 | Elain T Jonh E John D el al | 2007 | Interact CardioVase Thorac Surg2007，6，5： | 1 |
| 6 | Chemistry and microbial activity of forest and pasture riparian- zone soils along three Pacific Northwest streams 显示文摘 | Robert P G James A E Elaine R I | 1997 | Plant and Soil1997，190，1： | 1 |
| 7 | Bifidobacterial diversity in human feces detected by genus-specific PCR and denaturing gradient gel electrophoresis显示文摘 | Satokari R M Elaine E Vaughan | 2001 | Appl Environ Microbiol2001，67，2： | 1 |
| 8 | Insulin-Like growth factor binding protein-5 is a target of maVix metalloproteinase- 7:implications for epithelial-mesenchymal signaling显示文摘 | Elainers E Duval C McCaiq C | 2005 | Cancer Res2005，65，16： | 1 |
| 9 | Expansion of regulatory T cells in patients with Langerhans cell histiocytosis 显示文摘 | Senechal B Elain G Jeziorski E Grendin V Patey-Mariaud de Serre N Jaubert F | 2007 | PLoS Med2007，4，8： | 1 |
| 10 | Rising thyroid cancer incidencein the United States by demographic and tumor characteristics,1980- 2005 显示文摘 | Lindsey E Kangmin Z Elain R | 2009 | Cancer Epidemiol Biomarkers Prev2009，18，3： | 1 |
| 11 | Hormonal and histological studies related to in vitro banana bud formation显示文摘 | Gilmar R Z Gilberto B K Jane E K Elaine C R | 2000 | Plant Cell Tissue and Organ Culture2000，63，： | 1 |
| 12 | lnterspinous process implantation for the treatment of neurogenic intermittent claudi- cation显示文摘 | Heyrani N Picinic Norheim E Elaine Ku Y | 2012 | Anesth Pain Med2012，2，1： | 1 |
| 13 | Tissue Doppler echocardingraphy evidence of reverse remodeling and improved synchronicity by simultaneously therapy in heart failure显示文摘 | Cheuk-Man Y Elaine C John E | 2002 | Circulation2002，105，： | 1 |
| 14 | Boerhaave's syndrome:a review of management and outcome 显示文摘 | Elain T Jonh E John D | 2007 | Interact CardioVasc Thorac Surg2007，6，5： | 1 |
| 15 | Sterile insect technique and mediterranean fruit Fly (Diptera:Tephritidae):Assessing the utility of aromatherapy in a hawaiian coffee field 显示文摘 | Todd E S Donald O M Charles R James E Elaine P | 2007 | Journal of Economic Entomology2007，100，2： | 1 |
| 16 | Human leukocyte antigen antibodies in chronic transplant vasculopathy—mechanisms and pathways显示文摘 | Fang Li Mary E Atz Elaine F Reed | 2009 | Current Opinion in Immunology2009，，5： | 1 |
| 17 | 性辅导和心血管疾病:实用方法显示文摘心血管疾病患者与其配偶应向医护人员寻求性辅导,以维持性生活质量,但证据显示实际情况并非如此:只有少数心脏病患者接受了性咨询。这对这些夫妻在心理、生理和生活质量上产生了消极影响。他们可能做出一些不必要的决定:认为性生活风险太大而停止性生活。两项科研报告对医护人员在参与这个重要课题时提供了更多的指导。一个团队包括医生,护士,物理治疗师,康复人员,以及相信通过性辅导可使性功能得到完全康复的其他人员。另一团队则在性辅导中采用一些实例进行心理干预,实践证明可以成功。本文提供了可行性的策略和循证性的方法以对心脏病患者及其配偶进行评估和性辅导,对有心肌缺血、心脏衰竭和装有起搏器的患者也提供了具体辅导。 | Elaine E Steinke Tiny Jaarsma | 2015 | Asian Journal of Andrology2015，17，1： | 1 |
| 18 | Controlled gene expression system for lactic acid bacteria: transferable nisin-inducible expression cassettes for Lactococcus, Leuconostoc, and Lactobacillus spp 显示文摘 | MICHIEL K MARKE M B ELAINE E V | 1997 | Appl Environ Microbiol1997，63，11： | 1 |
| 19 | Advanced molecular tools for the identification of lactic acid bacteria显示文摘 | Kaouther Ben Amor Elaine E Vaughan Willem M devos | 2007 | The Journal of Nutrition2007，，7： | 1 |
| 20 | Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005显示文摘 | Lindsey E Kangmin Z Elaine R | 2009 | Cancer Epidemiol Biomarkers Prev2009，18，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员