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| 1 | Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia显示文摘AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter(UES) abnormality, and clinical and manometric profiles were compared.Correlation between UES abnormality and sub-type(i.e.,hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also evaluated.RESULTS: Among all 41 patients, 24(58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response compared to those with no UES abnormality(P = 0.017).CONCLUSION: The presence of UES abnormalities in patients with achalasia significantly predicted poorer treatment response as compared to those with normal UES function. | Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John O Clarke Ellen Stein Bani Chander Roland | 2014 | World Journal of Clinical Cases2014，2，9： | 5 |
| 2 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 3 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 4 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 5 | Evalutation of cytokine gene expression in porcine spleen cells, peripheral blood mononuclear cells, and alveolar macrophages by competitive RT-PCR显示文摘 | In-Soo C Ellen W C Samuel K M | 2002 | FEMS Immunol Med Microbiol2002，34，： | 1 |
| 6 | Treatment of uranium-contaminated waters using organic-based permeable reactive barriers显示文摘 | Ellen C | 2006 | Federal Facilities Environmental Journal2006，17，1： | 1 |
| 7 | Strategic guidelines for street canyon geometry to achieve sustainable street air quality显示文摘 | ANDY T C ELLEN S P SO | 2001 | Atmosphere Environment2001，35，： | 1 |
| 8 | Peak discharge estimates of glacia-lake outburst floods and 'normal' climatic floods in the Mount Everest region,Nepal显示文摘 | DANIEL A C ELLEN E W | 2001 | Geomorphology2001，，1： | 1 |
| 9 | Clongying and nucleotide of Newcastle disease virus haemagglutinin-neuram inidase mRNA:identification of a putative sialic acid binding site显示文摘 | ELLEN D J PETER L C PTTER T L | 1987 | Vorlogy1987，156，： | 1 |
| 10 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 11 | Consumer brand confusion: A conceptual framework 显示文摘 | Ellen R F Phil W B Joseph A C | 1992 | Psychology and Marketing1992，9，2： | 1 |
| 12 | Openness,technology capital,and development显示文摘 | ELLEN R M EDWARD C P | 2009 | Journal of economic theory2009，，144： | 1 |
| 13 | 1998, Are Acquiring- Firm Shareholders Better Off after an Acquisition 显示文摘 | Magenheim Ellen B Edennis C Mueller | 1998 | Interamtional Journal of industrial Organization1998，7，3： | 1 |
| 14 | Insulin desensitization withinsulin lispro and an insulin pump in 5 year old child显示文摘 | SAJU S E ELLEN L C JAMES E G | 2000 | Ann Al-lergy Asthma Immunol2000，85，5： | 1 |
| 15 | Organic amendments to enhance herbicide biodegradation in conta minated soils显示文摘 | Thomas B M Jennifer K C Ellen L A | 2001 | Biology and Fertility of Soils2001，33，6： | 1 |
| 16 | An- odic construction of lamellar structured ZnO films using basic media via interfacial surfactant templating 显示文摘 | ELLEN M P STEINMILLER KYOUNG-SHIN C | 2007 | Langmuir2007，23，12： | 1 |
| 17 | Vanadate tetramer as the inhibiting species in enzyme reactions in vitro and in vivo显示文摘 | Debbie C C Ellen M W Steven R B | | 0，，： | 1 |
| 18 | Evidence based librarianship 显示文摘 | KOUFOGIANNAKIS D ELLEN C | 2002 | Feliciter2002，3，： | 1 |
| 19 | Functional foods: health claim-food product compatibility and the impact of health claim framing on consumer evaluation显示文摘 | Ellen van Kleef Hans C M van Trijp Pieternel Luning | 2005 | Appetite2005，44，3： | 1 |
| 20 | Free wall rupture in the elderly Deleterious effect of fibrinolytic therapy on the ageie elderly deleterious effect of fibrinolytic on the ageing heart显示文摘 | Ellen C Keeley A James A | 2005 | Euro pean Heart Journal2005，26，17： | 1 |
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