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| 1 | G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis显示文摘Estrogens play important roles in the development and progression of multiple tumor types.Accumulating evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly understood.Studies on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative colitis.GPER is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC cells.Thus,multiple lines of evidence suggest that GPER may play an important role in colorectal carcinogenesis.In this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC. | Damian Jacenik Ellen J Beswick Wanda M Krajewska Eric R Prossnitz | 2019 | World Journal of Gastroenterology2019，25，30： | 6 |
| 2 | Post stroke depression: epidemiology, pathophysiology, and biological treatment显示文摘 | Ellen M Whyte Benoit H Mulsant | 2002 | Biological Psychiatry2002，，： | 2 |
| 3 | Post-stroke depression:epidemiology, pathophysiology, and biological treatment 显示文摘 | Ellen M Whyte Benoit H et al | 2002 | Society of Biological Psychiatry2002，52，： | 1 |
| 4 | Evalutation of cytokine gene expression in porcine spleen cells, peripheral blood mononuclear cells, and alveolar macrophages by competitive RT-PCR显示文摘 | In-Soo C Ellen W C Samuel K M | 2002 | FEMS Immunol Med Microbiol2002，34，： | 1 |
| 5 | Audit committee compensation and the demand for monitoring of the financial reporting process显示文摘 | Engel Ellen Hayes Rachel M Wang Xue | | 0，，： | 1 |
| 6 | Nutrientremoval by NF and romembranes in a decentralized sanitation system 显示文摘 | Ellen M Van Voorthuizen Zwijnenburg A | 2005 | Water Research2005，，39： | 1 |
| 7 | Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex显示文摘 | Jürg Müller Craig M. Hart Nicole J. Francis Marcus L. Vargas Aditya Sengupta Brigitte Wild Ellen L. Miller Michael B. O’Connor Robert E. Kingston Jeffrey A. Simon | 2002 | Cell2002，，2： | 1 |
| 8 | Continuous monitoring, auditing needed for Sarbanes-Oxley显示文摘 | Ellen M Heffes | 2004 | Financial Executive2004，，： | 1 |
| 9 | Evaluation of a fully covered self-ex- pandable metal stent in liver transplant patients with bile leaks : mid-term analysis 显示文摘 | Phillips M S Saue B Bonatti H Rehan M E Smith L A Ellen K | 2009 | Gastrointest Endosc2009，69，： | 1 |
| 10 | The fermentation of soybean meal by rumen microbes in vitro reveals different ki- netic features for the inactivation and the degradation of trypsin inhibitor protein显示文摘 | Ellen MH StePhan M Klaus B | 2003 | Animal Feed Science and Tech- nology2003，106，14： | 1 |
| 11 | Influences of Customer Differences of Loyalty, Perceived Risk and Category Experience on Customer Satisfaction Ratings 显示文摘 | Johnson M S Garbarino Ellen Sivadas E | 2006 | International Journal of Market Research2006，48，5： | 1 |
| 12 | The Different Roles of Satisfaction,Trust,and Commitment in Customer Relationships显示文摘 | Garbarino Ellen Johnson M S | | 0，，02： | 1 |
| 13 | Openness,technology capital,and development显示文摘 | ELLEN R M EDWARD C P | 2009 | Journal of economic theory2009，，144： | 1 |
| 14 | Promoting Teaching Excellence:A Comparison of Two Performance-Based Teacher Assement Frameworks显示文摘 | Jonson Kathleen F Jones Ellen M | 1998 | Education1998，118，4： | 1 |
| 15 | Making the Most of a Gooi Story: Effective Use of Film as a Teaching Resource for Ethics 显示文摘 | Ellen M | 2003 | Teaching Theology and Reli- gion2003，，2： | 1 |
| 16 | Teaching EBP: integrating technology into academic curricula to facilitate evidence-based decision-making显示文摘 | Kathleen M Williamson Ellen Fineout-Overhoh Bridie Kent Alison M Hutchinson | 2011 | Worldviews on evidence-based nursing/Sigma Theta Tau International Honor Soci- ety of Nursing2011，8，4： | 1 |
| 17 | The role of behavioral experience in judging risks 显示文摘 | Halpern-Felsher B L Millstein S G Ellen J M | 2001 | Health Psy- chology2001，20，2： | 1 |
| 18 | Organic amendments to enhance herbicide biodegradation in conta minated soils显示文摘 | Thomas B M Jennifer K C Ellen L A | 2001 | Biology and Fertility of Soils2001，33，6： | 1 |
| 19 | Perceived trust worthiness of knowledge source: the moderating impact of rela tionship length显示文摘 | Levin Daneil Z Whitener Ellen M Rob Cross | 2006 | Journal of Applied Psychology2006，91，： | 1 |
| 20 | Nutrient removal by NF and RO membranes in a decentralized sanitation system显示文摘 | Ellen M van Voorthuizen Arie Zwijnenburg Matthias Wessling | 2005 | Water Res2005，39，15： | 1 |
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