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| 1 | Osteoporosis in primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC) is an autoimmune cholestatic liver disease with multiple debilitating complications. Osteoporosis is a common complication of PBC resulting in frequent fractures and leading to significant morbidity in this population, yet evidence for effective therapy is lacking. We sought to summarize our current understanding of the pathophysiology of osteoporosis in PBC, as well as current and emerging therapies in order to guide future research directions. A complete search with a comprehensive literature review was performed with studies from Pub Med, EMBASE, Web of Science, Cochrane database, and the Countway Library. Osteoporosis in PBC is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Despite this fundamental difference, current treatment recommendations are based primarily on experience with postmenopausal osteoporosis. Trials specific to PBC-related osteoporosis are small and have not consistently demonstrated a benefit in this population. As it stands, prevention of osteoporosis in PBC relies on the mitigation of risk factors such as smoking and alcohol use, as well as encouraging a healthy diet and weight-bearing exercise. The primary medical intervention for the treatment of osteoporosis in PBC remains bisphosphonates though a benefit in terms of fracture reduction has never been shown. This review outlines what is known regarding the pathogenesis of bone disease in PBC and summarizes current and emerging therapies. | Christopher J Danford Hirsh D Trivedi Konstantinos Papamichael Elliot B Tapper Alan Bonder | 2018 | World Journal of Gastroenterology2018，24，31： | 13 |
| 2 | Isolated intestinal neurofibromatous proliferations in the absence of associated systemic syndromes显示文摘Gastrointestinal tract involvement by neurofi bromatous lesions is rare and occurs most frequently as one of the systemic manifestations of generalized neurofibromatosis type 1 (NF1). In this setting, the lesions may manifest as focal scattered neurofi bromas or as an extensive diffuse neural hyperplasia designated ganglioneuromatosis. Occasionally, such lesions may be the initial sign of NF1 in patients without any other clinical manifestations of the disease. Rarely, cases of isolated neurofi bromatosis of the large bowel with no prior or subsequent evidence of generalized neurofi bromatosis have been documented. We present the case of a 52 year-old female with abdominal pain and alternating bowel habits. Colonoscopic evaluation revealed multiple small polyps in the cecum and the presence of nodular mucosa in the colon and rectum. Pathologic evaluation of the biopsies from the cecum, descending colon, sigmoid colon, and rectum revealed tangled fascicles of spindle cells expanding the lamina propia leading to separation of the intestinal crypts. Immunohistochemical stains helped confirm the diagnosis of diffuse intestinal neurofibromatosis. A thorough clinical evaluation failed to reveal any stigmata of generalized neurofibromatosis. This case represents a rare presentation of isolated intestinal neurofi bromatosis in a patient without classic systemic manifestations of generalized neurofibromatosis and highlights the need in such cases for close clinical follow-up to exclude neurofibromatosis type Ⅰ or multiple endocrine neoplasia type Ⅱ. | J Elliot Carter Javier A Laurini | 2008 | World Journal of Gastroenterology2008，14，42： | 9 |
| 3 | An evaluation of potential mechanism-based in activation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid显示文摘 | Polasek TM Elliot D J Somogyi AA | 2006 | Br J Clin Pharmacol2006，61，5： | 1 |
| 4 | A process-based rill erosion model显示文摘 | Elliot W J Laflen J M | 1993 | Trans ASAE1993，36，1： | 1 |
| 5 | Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium显示文摘 | Maxin-Castano M E Elliot S J Potier M | 2003 | Invest Ophthalmol Vis Sci2003，44，1： | 1 |
| 6 | A 2×2 achievement goal framework显示文摘 | Elliot A J McGregor H A | 2001 | Journal of Personality and Social Psychology2001，80，3： | 1 |
| 7 | The effect of temperature on membrane hydraulic conductivity显示文摘 | ELMOAZZEN H Y ELLIOT J A W MCGANN L E | 2002 | Cryobiology2002，45，： | 1 |
| 8 | Synthesis and characterization of carbonate hydroxyapatite显示文摘 | Roy D M Elliot J C | 1969 | Tiss Res1969，3，： | 1 |
| 9 | A general fractional white noise theory and applications to finance显示文摘 | Robert Elliot J John Van Der Hoek | 2003 | Mathematical Finance2003，13，2： | 1 |
| 10 | Failure of the mite-pathogenic fungus Neozygites tanajoae and the predatory mite Neoseiulus idaeus to control a population of the cassava green mite, Mononychellus tanajoa显示文摘 | Elliot S L Moraes G J de Mumford J D | 2008 | Experimental and applied acarology2008，，46： | 1 |
| 11 | A 2× 2 achievement goal framework显示文摘 | Elliot A J McGregor H A | 2001 | Journal of personality and social psychology2001，80，3： | 1 |
| 12 | Validation of the weather generator CLIGEN with precipition data from UGANDA显示文摘 | Elliot W J Arnold C D | 2001 | Trans ASAE2001，44，1： | 1 |
| 13 | Surfactant protein A modulates both innate and adaptive defense responses to pulmonary influenza A virus infection 显示文摘 | LeVine AM Hartshorn KL Elliot J | 2001 | Am J Physiol Lung Cell Mol Physiol2001，282，3： | 1 |
| 14 | A general fractional white noise theory and applications to finance显示文摘 | Elliot R J Hoek J | 2003 | Mathematical Finance2003，13，2： | 1 |
| 15 | The structure of large and small airways in nonfatal and fatal asthma显示文摘 | Carroll N Elliot J Morton A James A | | 0，，： | 1 |
| 16 | A 2x2 achievement goal framework显示文摘 | Elliot A J McGregor H A | 2001 | Journal of Personality and Social Psy- chology2001，80，3： | 1 |
| 17 | WEPP internetinterfacesforforesterosionprediction 显示文摘 | Elliot W J | 2004 | Journal of the American Water Resources Association2004，40，2： | 1 |
| 18 | Therapeutic benefits of young, but not old, adipose-derived mesenchymal stem cells in a chronic mouse model of bleomycin-induced pulmonary fibrosis显示文摘 | Tashiro J Elliot SJ Gerth DJ | 2015 | Transl Res2015，166，6： | 1 |
| 19 | Pedestrian head translation, rotation and impact velocity:the influence of vehicle speed, pedestrian speed and pedestrian gait显示文摘 | J R ELLIOT'r C K SIMMA D P WOOD | 2012 | Accident Analysis and Prevention2012，45，： | 1 |
| 20 | A graphical simulation model of the entire DNA process associated with the analysis of short tandem repeat loci显示文摘 | Gill P Curran J Elliot K | | 0，，： | 1 |
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