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| 1 | 青贮饲料中接种乳酸菌对黑白花奶牛甲烷排放和生产性能的影响显示文摘乳酸菌菌剂(LAB)通过增加青贮饲料中乳酸和其他有机酸类含量、降低饲料p H来提高饲料品质,防止酸败。本试验在青贮饲料中添加LAB,改变青贮饲料品质及其在瘤胃中的发酵条件,探索饲料中添加LAB对奶牛干物质采食量(DMI)、消化率、产奶量、牛奶品质和甲烷(CH4)排放量的影响。8头泌乳中期荷斯坦-黑白花杂交奶牛根据产奶量分成高产和低产两组,采用4×4拉丁方阵设计21 d试验。CH_4排放量采用间接量热法测量。各组青贮饲料(主要成分为黑麦草)分为空白组、长期添加LAB组、短期添加组(饲喂前16 h添加)和长短期综合添加组。所有饲料都由牧草青贮和复合物构成(干物质基础上的比例为7525)。长期添加组菌剂中植物乳杆菌、乳酸乳球菌和布氏乳杆菌比例为102070,短期添加组为乳酸乳球菌。试验结果表明,长期添加组和短期添加组对奶牛干物质摄入量(DMI)、中性洗涤纤维(NDF)、脂肪消化率、氮含量和能量平衡无显著影响,对乳成分(尤其是尿素)、乳脂肪、乳蛋白质和牛奶中微生物总数均无显著影响。但长期添加LAB使产奶量有增加趋势。长期添加组和短期添加组的奶牛中CH_4排放量无显著变化。其中,长期添加组中以k J·kg^(-1)为单位的代谢体重有提高趋势。试验结果得出引起动物生产性能改变的LAB最小添加量,包括长期和短期的。虽然其他研究表明青贮饲料中添加菌剂能对奶牛生产性能产生有利的显著影响,但本试验由于剂量、青贮饲料基底牧草选择和保存条件等因素的差异,未产生显著影响。 | Ellis J L Hindrichsen I K Klop G Kinley R D Milora N Bannink A Dijkstra J | 2016 | 饲料博览2016，0，9： | 3 |
| 2 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 3 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 5 | Fuel cell systems efficient,flexible energy conversion for the 21st century显示文摘 | Von Spakovsky M R Nelson D J | 2001 | Proc IEEE2001，89，12： | 1 |
| 6 | 'Forbidden zone subduc- tion of sediments to 150 km depth The reaction of dolomite to magnesite plus aragonite in the UHPM metapeites from west- ern Tianshan, China 显示文摘 | Zhang L Ellis D J Arculus R J | 2003 | Journal of Metamorphic Geology2003，21，6： | 1 |
| 7 | Metabolomic approaches reveal that phosphatidic and phosphatidyl glycerol phospholipids are major discriminatory non-polar metabolites in responses by Brachypo-dium distachyon to challenge by Magnaporthe grisea 显示文摘 | Allwood J W Ellis D I Heald J K | 2006 | The Plant Journal2006，46，3： | 1 |
| 8 | Prediction of flow distributions and pressure changes in multi-layered annular packed beds显示文摘 | Heggs P J Ellis D I Ismail M S | | 0，，04： | 1 |
| 9 | Epithelioid pituicy- toma显示文摘 | Ellis J A Tsankova N M D' Amico R | 2012 | World Neurosurg2012，78，12： | 1 |
| 10 | Stability of African Pastoral Ecosystems: Alternate Paradigms and Implications for Development 显示文摘 | ELLIS J E SWIFT D M | 1988 | Journal of Range Management1988，41，6： | 1 |
| 11 | Urinary measurement of transforming growth factor-beta and type IV collagen as new markers of renal injury: application in diabetic nephropathy 显示文摘 | Ellis D Forrest KY Erbey J | 1998 | Clin Chem1998，44，： | 1 |
| 12 | Thermal and mechanical properties of a polypropylene nanocomposite显示文摘 | Ellis Thomas S D Angelo J S | 2003 | J Appl Polym Sci2003，，90： | 1 |
| 13 | In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice显示文摘 | Tuner J Ginzalez-Juarrero M Ellis D L | 2006 | J Immunol2006，173，11： | 1 |
| 14 | The response of grandstands to dynamic crowd loads显示文摘 | ELLIS B R LECTURER T J LITTLER J D | 2000 | Proceedings of the ICE - Structures and Buildings2000，，4： | 1 |
| 15 | Bone density ligand, sclerostin, directly inleracts with LRP5 but not LRPSG171V to modulate Wnt activity显示文摘 | Ellies D L Viviano B McCarthy J el al | 2006 | J Bone Miner Res2006，21，11： | 1 |
| 16 | Pb, U and Th diffusion in nature zircon显示文摘 | LEE J WILLIAMS L ELLIS D | 1997 | Nature1997，390，13： | 1 |
| 17 | Ultrahigh pressure metamorphism in western Tianshan,China,part Ⅰ:evidences from the inclusion of coesite pseudomorphs in garnet and quartz exsolution lamellae in omphacite in eclogites显示文摘 | ZHANG Li-fei ELLIS D J JIANG Wen-bo | 2002 | American Mineralogist2002，87，： | 1 |
| 18 | Self-consistent molecular Hartree-Fock-Slater calculations Ⅰ:The computational procedure显示文摘 | Baerends E J Ellis D E Ros P | 1973 | Chemical Physics1973，2，： | 1 |
| 19 | The nuclear-retained noncoding RNA malat1 regulates alternative splicing by modulating sr splicing factor phosphorylation显示文摘 | Tripathi V Ellis J D Shen Z | | 0，，6： | 1 |
| 20 | Fear Perceptions in Public Parks: Interactions of Environmental Concealment, the Presence of People Recreating, and Gender显示文摘 | Jorgensen L J Ellis G D Ruddell E | 2013 | Environment and Behavior2013，45，7： | 1 |
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