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| 1 | Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases显示文摘哺乳动物的精子必须经历一系列生物化学、生理的修正,一起叫的 capacitation,在在 acrosome 反应(AR ) 以前的女繁殖的道。尽管蛋白质 kinases 被显示在 capacitation 和 AR 期间涉及细胞内部的 Ca 2+ 的规定,这些修正的机制很好没被描绘。在现在的评论,我们总结一些涉及 capacitation 的发信号的事件。在 capacitation 过程期间, phosphatidyl-inositol-3-kinase (PI3K ) 是经由一个蛋白质 kinase A (PKA ) 依赖者的 phosphorylated/activated 由蛋白质 kinase C α 的串联,和 downregulated;(PKCα) 。PKCα在 capacitation 的开始是活跃的,导致 PI3K inactivation。在 capacitation 期间, PKCα象 PP1γ 一样; 2 被 PKA 依赖的机制降级,允许 PI3K 的激活。PKA 的激活主要在 capacitation 期间取决于酸式碳酸盐依赖者生产的周期的腺苷 monophosphate (营地) 可溶的 adenylyl cyclase。PKA 的这激活在肌动朊聚合导致增加,必需品为 hyperactivated 活动性的发展处理,它为成功的授精是必要的。肌动朊聚合被果仁 2 以二个方法调停:首先,果仁 2 为 phospholipase D (PLD ) 激活,和秒充当一个余因子,作为绑并且禁止象 gelsolin 那样的切断肌动朊的蛋白质的一个分子。gelsolin 的酷氨酸 phosphorylation 为它的 inactivation 也在由 Src 家庭 kinase (SFK ) 的 capacitation 期间是重要的。在 AR 以前, gelsolin 被免除果仁 2 并且经历 dephosphorylation/activation,导致 AR,导致快 F 肌动朊 depolymerization。 | Debby Ickowicz Maya Finkelstein Haim Breitbart | 2012 | Asian Journal of Andrology2012，14，6： | 17 |
| 2 | F^ole and regulation of EGFR in actin remodeling in sperm :apacitation and the acrosome reaction显示文摘 | Haim Breitbart Nir Etkovitz | 2011 | Asian Journal of Andrology2011，13，1： | 8 |
| 3 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 4 | A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9显示文摘 | Mary Donoghue Frank Hsieh Elizabeth Baronas Kevin Godbout Michael Gosselin Nancy Stagliano Michael Donovan Betty Woolf Keith Robison Raju Jeyaseelan Roger E. Breitbart Susan Acton | 2000 | Circulation Research: Journal of the American Heart Association2000，，5： | 2 |
| 5 | An alternative algorithm for dosing transdermal fentanyl for cancer-related pain 显示文摘 | Breitbart W Chandler S Eagel B | 2000 | Oncology2000，14，： | 1 |
| 6 | Cartilage tissue engineering: current limitations and solutions显示文摘 | DA GRANDE AS BREITBART J MASON | 1999 | Clin Orthop1999，，： | 1 |
| 7 | Genomic analysis of uncultured marine viral communities显示文摘 | Breitbart M Salamon P Andresen b | 2002 | Proceedings of the National Academy of Sciences2002，99，14： | 1 |
| 8 | Metagenomic and small-subunit rRNA analyses reveal the genetic diversity of bacteria,archaea,fungi,and viruses in soil显示文摘 | Fierer N Breitbart M Nulton J | 2007 | App Microbiol Microb2007，73，： | 1 |
| 9 | Identifying patients at risk for and treatment of ma- jor psychiatric complications of cancer 显示文摘 | Breitbart W | 1995 | Support Care Cancer1995，3，： | 1 |
| 10 | Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with ad- vanced solid tumors显示文摘 | Brenner AJ Cohen YC Breitbart E | 2013 | Clin Cancer Res2013，19，14： | 1 |
| 11 | Cartilage and bone regeneration using gene enhanced tissue engineering 显示文摘 | MASON J M BREITBART A S BARCIA M | 2000 | Clin Orthop Relat Res2000，379，5： | 1 |
| 12 | Impact of cancer-related fatigue on the lives of patients:new findings from the fatigue coalition显示文摘 | Curt GA Breitbart W Cella D | 2000 | The Oncologist2000，5，5： | 1 |
| 13 | Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue coalition显示文摘 | Curt GA Breitbart W Bella D | 2000 | Oncologist2000，5，5： | 1 |
| 14 | Here a virus,there a virus,everywhere the same virus显示文摘 | Breitbart M Rohwer F | 2005 | TRENDS in Microbiology2005，13，6： | 1 |
| 15 | Impact of cancer related fa- tigue on the lives of patients:new findings from the fatigue coali- tion显示文摘 | Curt GA Breitbart W Cella D | 2005 | The Oncologist2005，5，： | 1 |
| 16 | Optimal configuration of OSPF aggregates显示文摘 | Rastogi R Breitbart Y Garofalakis M | 2003 | Networking IEEE/ACM Transactions on2003，，2： | 1 |
| 17 | Gene-enhanced tissue engineering: applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7gene显示文摘 | BREITBART AS GRANDE DA MASON JM | 1999 | Ann Plast Surg1999，42，5： | 1 |
| 18 | Spirituality and meaning in cancer显示文摘 | Breitbart W | 2005 | Revue Francophone de Psycho-Oncologle2005，4，4： | 1 |
| 19 | Genomic analysis of uncultured marine viral communities显示文摘 | BREITBART M SALAMON P ANDRESEN B | 2002 | Proc Natl Acad Sci USA2002，99，14： | 1 |
| 20 | Viral diversity and dynamics in an infant gut显示文摘 | Breitbart M Haynes M Kelley S | 2008 | Res Microbiol2008，159，： | 1 |
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