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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Chemical composition of dissolved organic matter in agroecosystems~ Correlations with soil enzyme activity and carbon and nitrogen mineralization 显示文摘 | TIAN L EMILY D WEI S | 2010 | Applied Soil Ecology2010，46，： | 1 |
| 3 | Management of multidrug-resistant organisms in healthcare settings,2006显示文摘 | Jane D S Emily R Marguerite J | 2007 | Am J Infect Control2007，35，102： | 1 |
| 4 | Plasma levels of soluble tumor necrosis factor receptors p55 and p75 in patients with alcoholic liver disease of increasing severity 显示文摘 | Naveau s Emilie D Balian A | 1998 | Hepatol1998，28，： | 1 |
| 5 | A Bayesian networks approach for predicting protein-protein interactions from genomic data显示文摘 | JANSEN R Yu H GREENBAUM D KLUGER Y KROGAN N J CHUNG S EMILI A SNYDER M GREENBLATT J F GERSTEIN M | 2003 | Science2003，302，5644： | 1 |
| 6 | Preimplantation exposure of mouse embryos to pal-mitic acid results in fetal growth restriction followed bycatch-up growth in the offspring显示文摘 | Emily S Jungheim Erica D Louden Maggie M-Y Chi | 2011 | Biology of Repro-duction2011，85，： | 1 |
| 7 | Increased dietary intake of co-3 polyunsaturated fatty acidsreduces pathological retinal angiogenesis显示文摘 | Kip M C San Giovanni J P Lofqvist C Christopher M A Chen J HiguchiA Hong S Elke A P Majchrzak S Carper D Ann H Kang J X Emily Y C Norman S Charles N S | 2007 | Nature Medicine2007，13，： | 1 |
| 8 | Cardiogenic shock complicating acute myocardial infarction—etiologies, management and outcome: a report from the SHOCK Trial Registry显示文摘 | Judith S Hochman Christopher E Buller Lynn A Sleeper Jean Boland Vladimir Dzavik Timothy A Sanborn Emilie Godfrey Harvey D White John Lim Thierry LeJemtel | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 9 | Patterns of colonization by Pseudomonas aeruginosa in intubated patients: a 3-year prospective study of 1,607 isolates using pulsed-field gel electrophoresis with implications for prevention of ventilator-associated pneumonia显示文摘 | Jordi Vallés Dolors Mariscal Pilar Cortés Pere Coll Ana Villagrá Emili Díaz Antonio Artigas Jordi Rello | 2004 | Intensive Care Medicine2004，，9： | 1 |
| 10 | ER in breast can-cer-Onlooker, passive player, or active protector显示文摘 | Emily M F Rebecca J D Margaret A S | 2008 | Steroids2008，73，： | 1 |
| 11 | A Bayesian networks approach for predicting protein-protein interactions from genomic data显示文摘 | Jansen R Yu H Greenbaum D Kluger Y Krogan N J Chung S Emili A Snyder M Greenblatt J F Gerstein M | 2003 | Science2003，302，5644： | 1 |
| 12 | The prevalence and risk factors of retinal microvascular abnormalities in older persons显示文摘 | Tien Yin Wong Ronald Klein A.Richey Sharrett Teri A Manolio Larry D Hubbard Emily K Marino Lewis Kuller Gregory Burke Russell P Tracy Joseph F Polak John S Gottdiener David S Siscovick | 2003 | Ophthalmology2003，，4： | 1 |
| 13 | Soil enzyme activities andorganic matter composition in a turfgrass chronosequence显示文摘 | Wei S Emily D Daniel B | 2006 | Plant Soil2006，288，： | 1 |
| 14 | Volatile antimicrobials from Muscodor albus,a novel endophytic fungus显示文摘 | GARY A S EMILIE D JOE S | 2001 | Microbiology2001，147，： | 1 |
| 15 | Resistant Kawasaki disease treated with anti-CD20显示文摘 | EMILIE S B-EATRICE B MARION D | 2012 | J Pediatrics2012，160，5： | 1 |
| 16 | Stream ecosystem response to small dam removal: Lessons from the Heartland显示文摘 | MARTIN W D EMILY H S CAILIN H O | 2005 | Geomorphology2005，71，： | 1 |
| 17 | A graph-theory framework for evaluating landscape connectivity and conservation planning显示文摘 | Emily S Minor D L U | 2008 | Conservation Biology2008，22，2： | 1 |
| 18 | Plasma levels of soluble tumor necrosis factor receptors p55 and p75 in patients with alcoholic liver dis- ease of increasing severity 显示文摘 | Naveau S Emilie D Balian A | 1998 | J Hepatol1998，28，5： | 1 |
| 19 | Plasma levels of soluble tumor necrosis factor recetors p55 and p75 in patients with alcoholic liver of increasing seveity显示文摘 | Naveau S Emilie D Balian A | 1998 | J Hepatol1998，28，： | 1 |
| 20 | Investigations of Internal Interactions between the Parasitic Barnacle Callinectes Sapidus (Brachyura:Portunidae) using PCR Techniques显示文摘 | Timothy D S Emily B Ashley B M | | 0，，02： | 1 |
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