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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Early detection of response to imatinib therapy for gastrointestinal stromal tumor by using 18F-FDG-positron emission tomography and computed tomography imaging显示文摘有变形胃肠的基质肿瘤的 41 年的老女性被指 18F-FDG-positron 排放断层摄影术和计算断层摄影术(PET/CT ) 与 imatinib 在一个月前后扫描治疗(Glivec 收款机, Gleevec 收款机, Novartis,巴塞尔,瑞士) ,一个酷氨酸激酶禁止者(400 mg/d ) 。新陈代谢的反应在一月治疗前后被评估。最大的 standardised 举起价值(SUV ) 的减少是 79%( 从 9.8 ~ 2.1 ) 。正电子排放断层摄影术在 imatinib 治疗的一个月以后表明了完全的新陈代谢的反应。另外,以前的损害与花冠相比是计算机化的 tomographic 图象。根据 CT 图象在在治疗前后的肿瘤的尺寸没有差别。然而,新陈代谢的活动被禁止。18F-FDG-PET 是为对在有胃肠的基质肿瘤的病人的一个月 imatinib 治疗的反应的察觉的一个珍贵方法。 | Sabri Zincirkeser Alper Sevinc M Emin Kalender Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，15： | 7 |
| 3 | Effect of sunitinib on metastatic gastrointestinal stromal tumor in patients with neurofibromatosis type 1: A case report显示文摘Gastrointestinal stromal tumor (GIST) represents the most common mesenchymal malignancy of the gastrointestinal (GI) tract. In neurofibromatosis (NF), the increased incidence of tumor needs to be considered even in non-symptomatic individuals. Patients with neurofibromatosis NF type 1 have an increased risk of developing GI tumors including rare types such as GIST. We report a case of GIST in a 53-year-old male patient with neurofibromatosis. The patient was diagnosed with NF four years ago and his medical history revealed that he was hospitalized 5 times with a provisional diagnosis of massive lower gastrointestinal bleeding. GIST was diagnosed at explorative laparotomy and the tumor was 21 cm × 13 cm × 7 cm in size. Immunohistochemical examination showed that vimentin, actin and CD117 were positive. Computerized tomography showed peritoneal implants three months later. Imatinib mesylate (600 mg/d) was initiated. However, control computerized tomography revealed liver and omental metastasis. The dosage was elevated to 800 mg/d. Despite high dosage, the progression of the metastatic lesions continued in the liver and omentum. The patient started oral sunitinib malate (Sutent? Pfizer Inc, New York, NY, USA) 50 mg per day for 4 consecutive weeks, followed by 2 wk off per treatment cycle. The metastatic lesions in the liver and omentum were decreased in size after four courses, suggesting that sunitinib is also an effective treatment modality for metastatic GIST in NF patients. | M Emin Kalender Alper Sevinc Ediz Tutar Akif Sirikci Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，18： | 5 |
| 4 | Evaluation imPact of long-term usage of inhaled fluticasone ProPionate on ocular functions in children with asthma 显示文摘 | Emin O Fatih M Mustafa O | 2011 | Steroids2011，76，6： | 1 |
| 5 | Evaluation impact of long-term usage of inhaled fluticasone propionate on ocular functions in children with asthma 显示文摘 | Emin O Fatih M Mustafa O | 2011 | Steroids2011，76，6： | 1 |
| 6 | Discharging capacity of rectangular side weirs in straight open channels 显示文摘 | M Emin Emiroglu Hayrullah Agaccioglu Nihat Kaya | 2011 | Flow Measurement and Instrumen- tation2011，22，： | 1 |
| 7 | Pre-har-vest spray application of methyl jasmonate plays an important rolein fruit ripening,fruit quality and bioactive compounds of Japa-nese plums显示文摘 | EMINE K BURHAN O SULEYMAN M HUSEYIN A | 2014 | Scientia Horticulturae2014，176，11： | 1 |
| 8 | Use of clinoptilolite for the removal of nickel ions from water: Kinetics and thermodynamics 显示文摘 | M Emin Argun | 2008 | Journal of Hazardous Materials2008，150，： | 1 |
| 9 | Erythrocytes induce proinflammatory endothelial activation in hypoxia 显示文摘 | Huertas A Das SR Emin M | 2013 | Am J Respir Cell Mol Biol2013，48，： | 1 |
| 10 | Edge detection in noisy images by neuro-fuzzy processing 显示文摘 | Emin M Y | 2007 | AEU-International Journal of Electronics and Communications2007，61，2： | 1 |
| 11 | Effects of spironolactone on heart rate variability and left ventricular systolic function in severe ischemic heart failure显示文摘 | Mehmet Emin Korkmaz Haldun Müderriso?lu Melek Ulu?am Bülent ?zin | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 12 | Metal chelating and hydrogen peroxide scavenging effects of melatonin显示文摘 | GULCIN i EMIN M BUYUKOKUROGLU | 2003 | Journal of Pineal Research2003，34，4： | 1 |
| 13 | Leac- hing of malachite ore in NH3-saturated water 显示文摘 | Arzutug M Emin Kocakerim M Muhtar Copur M | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 14 | Droplet breakup and coalescence in a twin screw extrusion processing of starch based matrix显示文摘 | Emin M A Schuehmann H P | 2013 | Journal of Food Engineering2013，116，1： | 1 |
| 15 | Dynamic joh-shop scheduling using reinforcement learning agents显示文摘 | Aydin M Emin Oztemel Ercan | 2000 | Robotics and Autonomous Systems2000，33，23： | 1 |
| 16 | Dynamicjob-shop scheduling using reinforcement leaming agents 显示文摘 | Emin Aydin M Ercan Oztemel | 2000 | Robotics and Autonomous Systems2000，33，： | 1 |
| 17 | Hierarchical estimation and seg-mentation of dense motion fields 显示文摘 | M'EMIN E PEREZ P | 2002 | International Jour-nal of Computer Vision2002，46，2： | 1 |
| 18 | A converse comparison theorem for backward stochastic differential equations and related properties of g-expectation显示文摘 | Briand P Coquet F Hu Y M′emin J. Peng S | | 0，，： | 1 |
| 19 | Filtration-consistent nonlinear expectations and related g-expectations显示文摘 | Coquet F Hu Y M′emin J Peng S | | 0，，： | 1 |
| 20 | Analysis of the dispersive efficien- cy in a twin-screw extrusion processing of starch based matrix 显示文摘 | Emin M A Schuchmann H P | 2013 | Journal of Food Engineering2013，，115： | 1 |
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