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2篇 您的检索式：作者名="Emmanuelle Ruiz"

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		题名	作者	年代	出处	被引量
	1	Epithelial-mesenchymal transition transcription factors and mi RNAs: “Plastic surgeons” of breast cancer显示文摘Growing evidence suggests that breast cancer cell plasticity arises due to a partial reactivation of epithelialmesenchymal transition(EMT) programs in order to give cells pluripotency, leading to a stemness-like phenotype. A complete EMT would be a dead end program that would render cells unable to fully metastasize to distant organs. Evoking the EMT-mesenchymal-toepithelial transition(MET) cascade promotes successful colonization of distal target tissues. It is unlikely that direct reprogramming or trans-differentiation without passing through a pluripotent stage would be thepreferred mechanism during tumor progression. This review focuses on key EMT transcriptional regulators, EMT-transcription factors involved in EMT(TFs) and the mi RNA pathway, which are deregulated in breast cancer, and discusses their implications in cancer cell plasticity. Cross-regulation between EMT-TFs and mi RNAs, where mi RNAs act as co-repressors or co-activators, appears to be a pivotal mechanism for breast cancer cells to acquire a stem cell-like state, which is implicated both in breast metastases and tumor recurrence. As a master regulator of mi RNA biogenesis, the ribonuclease type Ⅲ endonuclease Dicer plays a central role in EMTTFs/mi RNAs regulating networks. All these EMT-MET key regulators represent valuable new prognostic and predictive markers for breast cancer as well as promising new targets for drug-resistant breast cancers.	Caroline Moyret-Lalle Emmanuelle Ruiz Alain Puisieux	2014	World Journal of Clinical Oncology2014，5，3：	7
	2	Generation of dendritic cell–tumor cell hybrids by electrofusion for clinical vaccine application显示文摘	Katrina T. Trevor Cathleen Cover Yvette W. Ruiz Emmanuel T. Akporiaye Evan M. Hersh Didier Landais Rachel R. Taylor Alan D. King Richard E. Walters	2004	Cancer Immunology Immunotherapy2004，，8：	1

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