|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Firm -level implications of early stage venture capital investment An empirical inves- tigation显示文摘 | Engel D Keilbach M | 2007 | Journal of Empirical Finance2007，14，2： | 1 |
| 4 | Dynamics of GATA transcription factor expression during erythroid differentiation 显示文摘 | Leonard M Brice M Engel J D | 1993 | Blood1993，82，4： | 1 |
| 5 | CD4OL deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice 显示文摘 | Poggi M Engel D Christ A | 2011 | Arterinscler Thromb Vasc Biol2011，31，10： | 1 |
| 6 | Effects of moulting and environmental factors on trace metal body-burdens and haemocyanin concentrations in the American lobster,Homarus americanus显示文摘 | Engel D W Brouwer M Mercaldo-Allen R | 2001 | Marine Environmental Research2001，52，： | 1 |
| 7 | Authigenesis of magnetite in organic-rich sediment next to a dike: implications for thermoviscous and chemical remagnetizations显示文摘 | Katz B Elmore R D Engel M H | 1998 | Earth and Planetary Science Letters1998，163，： | 1 |
| 8 | Estimating time varying risk premia in the term structure: The ARCH-m model 显示文摘 | Engel R F Lilien D M Robins R F | 1987 | Econometriea1987，，55： | 1 |
| 9 | A combined OFDM/SDMA approach 显示文摘 | Perre L V D Engels M G E | 2000 | IEEE J Select Areas Commun2000，18，11： | 1 |
| 10 | Metal regulation and molting in the blue crab, Callinectes sapidus: Metallothionein function in metal metabolism 显示文摘 | ENGEL D W BROUWER M | 1987 | Biological Bulletin1987，173，： | 1 |
| 11 | Effects of molting and environmental factors on trace metal body-burdens and hemocyanin concentrations in the American lobster, Homarus americanus 显示文摘 | Engel D W Brouwer M Allen M | 2001 | Mar Environ Res2001，52，： | 1 |
| 12 | Additives to prevent filamentous coke formation in endothermic heat exchangers显示文摘 | Wickham D T Engel J R Karpuk M E | 2000 | Prepr Pap Am Chem Soc Div Pet Chem2000，45，3： | 1 |
| 13 | Advances in the study of high intensity conditioning as a means of improving mineral flotation performance 显示文摘 | ENGEL M D MIDDLEBROOK P D JAMESON G J | 1997 | Minerals Engineering1997，10，1： | 1 |
| 14 | Purification of acetohydroxy acid synthase by separation in an aqueous two-phase system显示文摘 | ENGEL S BARAK Z CHIPMAN D M | 2000 | Journal of Chromatography B2000，7，10： | 1 |
| 15 | Chemical remagnetization and clay diagenesis: testing the hypothesis in the Cretaceous sedimentary rocks of northwestern Montana显示文摘 | Gill J D Elmore r D Engel M H | 2002 | Physics and Chemistry of the Earth2002，27，： | 1 |
| 16 | CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice 显示文摘 | Poggi M Engel D Christ A | 2011 | Arterioseler Thromb Vase Biol2011，31，10： | 1 |
| 17 | Histopathological studiesof staphylococcal alpha-toxin: effects on rabbit corneas显示文摘 | Moreau J M Sloop G D Engel L S | 1997 | Curr EyeRes1997，，16： | 1 |
| 18 | Sperm cells of Zea mays have a complex complement of mRNAs显示文摘 | Engel M L Annie C Christian D | 2003 | Plant Journal2003，34，5： | 1 |
| 19 | 'CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice显示文摘 | Poggi M Engel D | | 0，，： | 1 |
| 20 | Advances in the study of high intensity conditioning as-ameans of improving mineral flotation performance 显示文摘 | Engel M D Middlebrook Jameson G J | 1997 | Minerals Engineering1997，10，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员