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| 1 | Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non-small cell lung cancer progression during first-generation tyrosine kinase inhibitor therapy: a prospective observational study显示文摘Introduction:Plasma circulating tumor DNA(ctDNA)is an ideal approach to detecting the epidermal growth factor receptor(EGFR)T790M mutation,which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase inhibitor(TKI)therapy.The present study aimed to explore the association of ctDNA-identified T790M mutation with disease failure sites and clinical prognosis in non-small cell lung cancer(NSCLC)patients.Methods:Patients who progressed on first-generation TKIs were categorized into failure site groups of chest limited(CF),brain limited(BF)and other(OF).Amplification refractory mutation system(ARMS)and droplet digital PCR(ddPCR)were used to identify the T790M mutation in ctDNA.Prognosis was analyzed with Kaplan-Meier methods.Results:Overall concordance between the two methods was 78.3%.According to both ARMS and ddPCR,patients in the OF group had a significantly higher rate of T790M mutation than did patients in the BF and CF groups(P<0.001),and a significantly higher T790M mutation rate was also observed in OF-group patients than in those in the CF and BF groups(P<0.001).AZD9291 was found to be an excellent treatment option and yielded the longest survival for T790M+patients in all groups who had progressed on EGFR-TKIs;for other treatments,the prognosis of T790M−patient subgroups varied.Conclusions:The present study demonstrates that T790M mutation in ctDNA is associated with failure sites for NSCLC patients after EGFR-TKI therapy and indicates that both failure site and T790M mutational status greatly influ-ence treatment selection and prognosis. | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | Cancer Communications2018，38，1： | 12 |
| 2 | A large carbon pool in lake sediments over the arid/semiarid region, NW China显示文摘Carbon burial in lake sediments is an important component of the global carbon cycle. However, little is known about the magnitude of carbon sequestered in lake sediments over the arid/semiarid region of China(ASAC).In this study, we estimate both organic and inorganic carbon burial since *AD 1800 based on nine lakes in ASAC,and discuss the most plausible factors controlling carbon burial. Our estimates show that the annual organic carbon burial rate(OCBR) ranges from 5.3 to 129.8 g cm-2year-1(weighted mean of 49.9 g cm-2year-1), leading to a standing stock of 1.1–24.0 kg cm-2(weighted mean of 8.6 kg cm-2)and a regional sum of *108 Tg organic carbon sequestered since *AD 1800. The annual inorganic carbon burial rate(ICBR) ranges from 11.4 to 124.0 g cm-2year-1(weighted mean of 48.3 g cm-2year-1), which is slightly lower than OCBR. The inorganic carbon standing stock ranges from2.4 to 26.0 kg cm-2(weighted mean of 8.1 kg cm-2),resulting in a sum of *101 Tg regional inorganic carbon burial since *AD 1800, which is slightly lower than the organic carbon sequestration. OCBR in ASAC shows a continuously increasing trend since *AD 1950, which is possibly due to the high autochthonous and allochthonous primary production and subsequently high sedimentation rate in the lakes. This increasing carbon burial is possibly related to both climatic changes and enhanced anthropogenic activities, such as land use change, deforestation, and eutrophication in the lake. Furthermore, OCBR and ICBR are expected to continuously increase under the scenario of increasing precipitation and runoff and enhanced anthropogenic activities.The results of this research show that the buried carbon in lake sediments of the ASAC region constitutes a significant and large carbon pool, which should be considered and integrated into the global carbon cycle. | Jianghu Lan Hai Xu Bin Liu Enguo Sheng Jiangtao Zhao Keke Yu | 2015 | Chinese Journal Of Geochemistry2015，34，3： | 10 |
| 3 | 第一代酪氨酸激酶抑制剂治疗中发生进展的非小细胞肺癌血浆表皮生长因子受体(EGFR)T790M突变提示了失败部位并预测了临床预后:一项前瞻性观察研究显示文摘背景与目的血浆循环肿瘤DNA(circulating tumor DNA,ctDNA)是检测表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变的理想方法。T790M突变是第一代EGFR酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)耐药的主要机制。本研究旨在探讨ctDNA来源的T790M突变与非小细胞肺癌(non-small cell lung cancer,NSCLC)患者疾病失败部位及临床预后的关系。方法第一代TKI治疗发生进展的患者被分为局限胸内进展(chest limited,CF)、局限颅内进展(brain limited,BF)和其他部位进展(other,OF)组。采用扩增阻滞突变系统(amplification refractory mutation system,ARMS)和微滴式数字PCR(droplet digital PCR,ddPCR)对ctDNA中T790M突变进行了检测。采用Kaplan-Meier法分析了预后。结果 2种方法的总体一致性为78.3%。根据ARMS和ddPCR,OF组患者的T790M突变率明显高于BF组和CF组(P <0.001),OF组的T790M突变丰度也明显高于CF组和BF组(P <0.001)。AZD9291是T790M+患者最佳治疗选择,为EGFR-TKI治疗后进展的所有组中T790M+患者提供了最长的生存期;接受其他治疗的T790M-患者亚组的预后各不相同。结论本研究表明ctDNA中T790M突变与NSCLC患者EGFR-TKI治疗失败部位相关,失败部位和T790M突变状态对治疗选择和预后都有很大影响。 | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | 癌症2018，37，9： | 4 |
| 4 | Water-driven photoluminescence reversibility in CsPbBr_(3)/PDMSPUa composite显示文摘Strong ionic character endows all-inorganic perovskite nanocrystals(NCs)with particular optoelectronic features when interacting with common polar solvents,such as water.However,the interaction mechanism of water affecting perovskite NCs is still lack of in-depth understanding.This study systematically explores the roles of water on CsPbBr_(3) nanocrystals(CNCs)by finely controlling the polymer coating degree of polydimethylsiloxane-based polyurea(PDMS-PUa).Through this coating,the effect of water on CNCs is found to experience from“fluorescence quenching”owing to irreversible crystal decomposition towards“forward fluorescence reversibility”by crystal destruction and recrystallization.With gradually enhanced coating,a phenomenon of“reverse fluorescence reversibility”is further observed in that water begins to passivate the CNCs’defect states.Finally,“fluorescent balance”can be achieved with a thick enough coating,where water can hardly contact with the CNCs.Inspired by the fluorescence reversible mechanism discovered,a new wearable intelligent sensing skin is demonstrated by using the CsPbBr_(3)/PDMS-PUa composite as raw material.Both water contact and humidity change can be perceived through photoluminescence(PL)intensity,corresponding to stimuli-responsive sensory nerves of human skin.It is expected that these findings will shed some new lights on perovskite NCs. | Junhu Cai Chenhui Wang Xinpei Hu Yuanyuan Ye Lijuan Zhong Enguo Chen Yun Ye Sheng Xu Jie Sun Qun Yan Tailiang Guo | 2022 | Nano Research2022，15，7： | 4 |
| 5 | Emerging vaccine nanotechnology: From defense against infection to sniping cancer显示文摘Looking retrospectively at the development of humanity, vaccination is an unprecedented medical landmark that saves lives by harnessing the human immune system. During the ongoing coronavirus disease 2019(COVID-19) pandemic, vaccination is still the most effective defense modality. The successful clinical application of the lipid nanoparticle-based Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines highlights promising future of nanotechnology in vaccine development. Compared with conventional vaccines, nanovaccines are supposed to have advantages in lymph node accumulation,antigen assembly, and antigen presentation;they also have, unique pathogen biomimicry properties because of well-organized combination of multiple immune factors. Beyond infectious diseases, vaccine nanotechnology also exhibits considerable potential for cancer treatment. The ultimate goal of cancer vaccines is to fully mobilize the potency of the immune system as a living therapeutic to recognize tumor antigens and eliminate tumor cells, and nanotechnologies have the requisite properties to realize this goal.In this review, we summarize the recent advances in vaccine nanotechnology from infectious disease prevention to cancer immunotherapy and highlight the different types of materials, mechanisms, administration methods, as well as future perspectives. | Chan Feng Yongjiang Li Bijan Emiliano Ferdows Dylan Neal Patel Jiang Ouyang Zhongmin Tang Na Kong Enguo Chen Wei Tao | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 6 | Biogenic silica contents of Lake Qinghai sediments and its environmental significance显示文摘在在湖沉积的源於生物的硅石(BSi%) 的层次的变化广泛地被使用了以便学习湖生产率和 palaeoclimatic 变化。然而,源於生物的硅石(BSi ) 的起源需要为每个湖被调查,特别为大湖,作为做在 BSi 和相关环境因素的层次之间的关系。在这研究,我们测量了在金海湖集水以内在湖沉积,河沉积,和表面土壤包含的 BSi 的百分比,并且在抽取过程前后比较了硅藻和 phytoliths 的数量和形状。结果建议在湖沉积的 BSi 首先从内长的硅藻被导出;因此, BSi 层次能被用来在湖以内在主要生产率反映变化。进一步的比较证明在长期的 timescales 上,在 BSi% 的变化与在全部的器官的碳(TOC ) 和谷物尺寸的那些通常一致,反映在金海湖的主要生产率上的降水的主导的影响。然而,在短期的 timescales 上,在 BSi% 之间的关系和在 BSi% 和谷物尺寸之间的 TOC 和那不清楚或稳定。例如, BSi% 有时有谷物的 covaried 尺寸,而是它与谷物尺寸有关有时从阶段与或甚至相反地。我们推测那气候和环境过程例如冲淡效果,影响短期的 BSi% 和它的相关环境意义。作为结果, BSi% 应该在不同时间规模上有选择地被用作气候的变化的指示物。 | Bin LIU Hai XU Jianghu LAN Enguo SHENG Shuai CHE Xinying ZHOU | 2014 | Frontiers of Earth Science2014，8，4： | 4 |
| 7 | Late Holocene hydroclimatic variations and possible forcing mechanisms over the eastern Central Asia显示文摘Hydroclimatic variations over the eastern Central Asia are highly sensitive to changes in hemispheric-scale atmospheric circulation systems. To fully understand the long-term variability and relationship between hydroclimate and atmospheric circulation system, we present a high-resolution lascustrine record of late Holocene hydroclimate from Lake Sayram, Central Tianshan Mountains, China, based on the total organic carbon, total nitrogen, and carbonate contents, carbon/nitrogen ratios, and grain size. Our results reveal four periods of substantially increased precipitation at the interval of 4000–3780, 3590–3210, 2800–2160, and 890–280 cal yr BP, and one period of slightly increased precipitation from 1700–1370 cal yr BP. These wetter periods broadly coincide with those identified in other records from the mid-latitude Westerlies-dominated eastern Central Asia, including the northern Tibetan Plateau. As such, a similar hydroclimatic pattern existed over this entire region during the late Holocene. Based on a close similarity of our record with reconstruction of North Atlantic Oscillation indices and solar irradiance, we propose that decreased solar irradiance and southern migration of the entire circum-North Atlantic circulation system, particularly the main pathway of the mid-latitude Westerlies, significantly influenced hydroclimate in eastern Central Asia during the late Holocene. Finally, the inferred precipitation at Lake Sayram has increased markedly over the past 100 years, although this potential future changes in hydroclimate in Central Asia need for further investigation. | Jianghu LAN Hai XU Keke YU Enguo SHENG Kangen ZHOU Tianli WANG YuANDa YE Dongna YAN Huixian WU Peng CHENG Waili ABULIEZI Liangcheng TAN | 2019 | Science China Earth Sciences2019，62，8： | 3 |
| 8 | Application of extracorporeal membrane oxygenation in the endoscopic treatment of severe benign airway stenosis:A case report and literature review显示文摘Ventilation strategies in patients with severe tracheal stenosis should be tailored to the patient according to the underlying cause and narrowing location.This report is on a case of a 68-year-old male patient,who was admitted for radiotherapy because of esophageal cancer and then developed severe stenosis at the cervical trachea.We used venovenous extracorporeal membrane oxygenation to secure the airway and ensure adequate oxygenation.Then urgent endoscopic balloon dilation of airway stenosis was successfully performed under general anesthesia.This case shows that venovenous extracorporeal membrane oxygenation can be used in endoscopic tracheal procedures for patients with severe benign stenosis in the upper-trachea who are unable to tolerate conventional ventilation. | Yuyuan Liang Jihong Zhu Xing Zheng Qing Qiao Yaolin Guan Jisong Zhang Enguo Chen | 2021 | Laparoscopic, Endoscopic and Robotic Surgery2021，4，2： | 2 |
| 9 | Discrete Stock-effort Dynamical Model of a Fishery on Three Fishing Zones With a Protected One显示文摘 | GU Enguo | | 0，，： | 1 |
| 10 | On some global bifurcations of domains of feasible trajectories: analysis of recurrence equations 显示文摘 | Gu Enguo Rung J | 2005 | Int J of Bifurcation and Chaos2005，14，5： | 1 |
| 11 | Global analysis of an ecological populational model with an external interference显示文摘 | GU Enguo | | 0，，： | 1 |
| 12 | On some global bifurcations of domains of feasible trajections:analysis of recurrence equations显示文摘 | GU Enguo Rung J | | 0，，05： | 1 |
| 13 | The feasible domains and their bifurcations in an extended Logistic model with an external interference 显示文摘 | Gu Enguo | 2007 | Int J of Bifurcation and Chaos2007，17，3： | 1 |
| 14 | On the global analysis of dynamics in a delayed regulation model with an external interference 显示文摘 | Gu Enguo Hao Y D | 2007 | Chaos Solitons and Fractals2007，34，4： | 1 |
| 15 | Global analysis of an ecological populational model with an external interference 显示文摘 | Gu Enguo | 2007 | Chaos solitions and Fractal2007，32，： | 1 |
| 16 | An Improved Estimation of the Fixed Point'sNeighborhood in Controlling Discrete Chaotic Systems显示文摘This paper proposes a better method for determining the fixed point’sneighborhood in which the system remain stable when subjected to a linear law. Thevalidity of this method is shown by a theorem on effective local control of nonlinear,chaotic dynamical system, with numerical confirmation. The ways of implementing theobtained theorem in practice are proposed. | Enguo GU Jiong RUAN and Zhenxun HUANG(Institution of Mathematics Fudan University, Shanghai 200433, China) | 1998 | Communications in Nonlinear Science and Numerical Simulation1998，3，3： | 1 |
| 17 | On some global bifurcations of domains of feasible trajections: analysis of recurrence equations显示文摘 | Gu Enguo Rung J | 2005 | Int J of Bifurcation and Chaos2005，14，5： | 1 |
| 18 | Global bifurcations of domains of feasible trajectories: analysis of a predator-prey model显示文摘 | Gu Enguo | 2006 | Int J of Bifurcation and Chaos2006，16，8： | 1 |
| 19 | Complex dynamics analysis on fish stock harvested by two players with heterogeneous rationality显示文摘 | Gu Enguo | | 0，，02： | 1 |
| 20 | Optimisation of Ultrasound‐assisted Extraction of Puerarin and Total Isoflavones from Puerariae Lobatae Radix ( Pueraria lobata (Wild.) Ohwi) with Response Surface Methodology显示文摘 | Yanfang Wu Xinsheng Wang Enguo Fan | 2012 | Phytochem Anal2012，，5： | 1 |
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