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| 1 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 2 | Short-Term effects of Ni- trogen Dioxide on mortality and susceptibility factors in 10 Italian cities : The EpiAir Study 显示文摘 | Monica C Ennio C Massimo S | 2011 | Environmental Health Perspectives2011，119，11： | 1 |
| 3 | The english auction with differentiated commodities 显示文摘 | Faruk G Ennio S | 2000 | Journal of Economic Theory2000，92，1： | 1 |
| 4 | Gela histological scoring system for post‐treatment biopsies of patients with gastric MALT lymphoma is feasible and reliable in routine practice显示文摘 | Christiane Copie‐Bergman Andrew C. Wotherspoon Carlo Capella Teresio Motta Ennio Pedrinis Stefano A. Pileri Francesco Bertoni Annarita Conconi Emanuele Zucca Maurilio Ponzoni Andrés J. M. Ferreri | 2012 | Br J Haematol2012，，1： | 1 |
| 5 | Gastrointestinal manifestations in children with cerebral palsy显示文摘 | ENNIO DG ANNAMARIA S GUGLIELMO | 1999 | Brain & development1999，21，： | 1 |
| 6 | Influence of variables related to soil weathering on the geomechanical performance of tropical soils显示文摘This paper presents an experimental and analytical investigation of the influence of variables related to soil weathering on the geomechanical performance of sand-silt mixtures containing lateritic soils,i.e.intensely weathered tropical soils with the influence of interparticle bonding.The sand-silt mixtures containing different relative proportions between uniform sand and lateritic soil were produced,and geomechanical soil characterization tests were performed.Based on the results,a transition from a primarily coarse-to a fine-grained prevailing soil structure was found to cause considerable impact on the geomechanical performance of these soils,as evidenced by design variables related to soil mineralogy and size distribution characteristics.Specifically,fines contents of both individual soil particles and soil aggregations were found to correlate with experimental results,while the relative proportion between sesquioxides(aluminum,and iron oxides),and silica,i.e.sesquioxide-silica ratios(SSR^(-1)),facilitated estimates concerning changes in geomechanical performance.Finally,the application of the sandsilt mixtures containing lateritic soil on soil walls reinforced with polymeric strips was also evaluated,further emphasizing the potential advantages of adopting variables related to soil weathering on design guidelines concerning tropical soils. | Rodrigo Cesar Pierozan Gregorio Luís Silva Araújo Ennio Marques Palmeira Celso Romanel | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，9： | 0 |
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