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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Protein kinase C modulates negatively the hepatocyte growth factor-induced migration,integrin expression and phosphatidylinositol 3-kinase activation显示文摘 | Annamaria G Sipeki S Bander E | 2004 | Cellular Signalling2004，16，5： | 1 |
| 3 | Overexpression of NPY and Y2 receptors in epileptic brain tissue:an endogenous neuroprotective mechanism in temporal lobe epilepsy显示文摘 | Annamaria V Günther S | 2004 | Neuropeptides2004，38，4： | 1 |
| 4 | Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer显示文摘 | Wang Enfeng Bhattacharyya S Annamaria S | 2011 | PlosOne2011，6，17： | 1 |
| 5 | The de Larosiere Report Regardingthe New Structure of European System of Financial Supervision 显示文摘 | Nagy A Pete S Benyovszki A Annamaria petru T Gyorfy L | 2010 | Theoretical and Applied Economics2010，17，11： | 1 |
| 6 | Enhanced glutathione levels and oxidoresistanee mediated by increased glucose-6-phosphate dehydrogenase expression 显示文摘 | Francesca S Annamaria F Angela I | 1999 | J Biol Chem1999，274，24： | 1 |
| 7 | Fiber(GLueo-mallnan)is beneficial in the treatment of childhood constipation显示文摘 | Vera LB Erasmo M Annamaria S | 2004 | Pediatrics2004，113，3： | 1 |
| 8 | Soil invertebrates as bioindicators of urban soil quality显示文摘 | LUCIA S CORNELIS A M ANNAMARIA R | 2012 | Environmental Pollution2012，161，： | 1 |
| 9 | Fiber(Gluco-mannan) is beneficial in the treatment of childhood constipation 显示文摘 | Vera LB Erasmo M Annamaria S | 2004 | Pdistries2004，113，3： | 1 |
| 10 | Complete genome sequence of a raccoon rabies virus isolate显示文摘 | Annamaria G S Susan A N D Bradley N W | 2008 | Virus Res2008，136，： | 1 |
| 11 | The microbial degradation of silk: a laboratory investigation显示文摘 | Annamaria S Maria R Tullia M | 1998 | International Biodeterioration &Biode - gradation1998，42，4： | 1 |
| 12 | Combined approach based on principal component analysis and canonical discriminant analysis for investigation hyperspectral plant response显示文摘 | Anna M S Annamaria C Mariangela D | 2012 | Italian Journal of Agronomy2012，7，3： | 1 |
| 13 | The Pearson system of utility functions显示文摘 | Marco L Annamaria S | 2006 | European J of Operational Research2006，172，2： | 1 |
| 14 | New forms of international cooperation in doctoral training:internationalisation and the international doctorate-one goal,two distinct models 显示文摘 | ANNAMARIA S D R | 2008 | Higher education in europe2008，33，1： | 1 |
| 15 | PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non–Small-Cell Lung Cancer显示文摘 | Luis G. Paz-Ares Filippo de Marinis Mircea Dediu Michael Thomas Jean-Louis Pujol Paolo Bidoli Olivier Molinier Tarini Prasad Sahoo Eckart Laack Martin Reck Jesús Corral Symantha Melemed William John Nadia Chouaki Annamaria H. Zimmermann Carla Visseren-Gru | 2013 | Journal of Clinical Oncology2013，，23： | 1 |
| 16 | Natural course of LGII en- cephalitis: 3-5years of follow-up without immunotherapy 显示文摘 | Monika S Annamaria M Ferenc K | 2014 | Journal of the Neurological Sciences2014，343，12： | 1 |
| 17 | Fiber( GLuco -mannan) is beneficial in the treatment of childhood constipation 显示文摘 | Vera LB Erasmo M Annamaria S | 2004 | Pediatries2004，113，3： | 1 |
| 18 | Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, random显示文摘 | Luis Paz-Ares Filippo de Marinis Mircea Dediu Michael Thomas Jean-Louis Pujol Paolo Bidoli Olivier Molinier Tarini Prasad Sahoo Eckart Laack Martin Reck Jesús Corral Symantha Melemed William John Nadia Chouaki Annamaria H Zimmermann Carla Visseren-Grul Ce | 2012 | Lancet Oncology2012，，3： | 1 |
| 19 | Fiber (GLueo-mallnan) is beneficial in the treatment of childhood constipation 显示文摘 | Vera L B Erasmo M Annamaria S | 2004 | Pediatrics2004，113，3： | 1 |
| 20 | Gastrointestinal manifestations in children with cerebral palsy显示文摘 | ENNIO DG ANNAMARIA S GUGLIELMO | 1999 | Brain & development1999，21，： | 1 |
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