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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Death in Guizhou-Late Tirassic drowning of the Yangtze carbonate platform显示文摘 | Enos P Wei Jia-yong Lehrmann D J | 1998 | Sedimentary Geology1998，118，： | 1 |
| 3 | Facies distribution and retreat of Middle Triassic Platform margin, Guizhou province, South China显示文摘 | Enos P Wei Jiayong Yah Yangji | 1997 | Sedimentary1997，44，3： | 1 |
| 4 | Lofer cyclothems revisited( Late Trias- sic, Northern Alps, Austria) 显示文摘 | Enos P Samankassou E | 1998 | Facies1998，38，： | 1 |
| 5 | Lofer cyclothems revisited (Late Triassic,Northern Alps,Austria)显示文摘 | Enos P Samankassou E | 1998 | Facies1998，38，： | 1 |
| 6 | Death in Guizhou-Late Triassic dromning of the Yangtze carbonate platform显示文摘 | Enos P Wei Jiayong Lehmmnn D J | 1998 | Sedimentary Geology1998，118，： | 1 |
| 7 | Flow regimes in debris flow 显示文摘 | Enos P | 1977 | Sedimentology1977，24，1： | 1 |
| 8 | Pore networks in Holocene carbonate sedi-ments显示文摘 | Enos P Sawatsky L H | 1981 | Journal of Sedimentary Research1981，51，3： | 1 |
| 9 | Pore networks in Holocene carbonate sediments显示文摘 | Enos P Sawatsky L H | 1981 | Journal of Sedimentary Petrology1981，51，3： | 1 |
| 10 | Flow regimes in debris flow显示文摘 | ENOS P | 1977 | Sedimentology1977，24，： | 1 |
| 11 | Estimating the sensitivity and specificity of diagnostic tests and disease prevalence when the true disease state is unknown 显示文摘 | Enoe C Georgiadis M P Johnson W O | 2000 | Prev Vet Med2000，，45： | 1 |
| 12 | Caveolae biochemical analysis显示文摘 | Chatenay-Rivauday C Cakar ZP J eno P | 2004 | Mol boil Rep2004，31，： | 1 |
| 13 | Pore space in Holocene carbonate sedi-ments显示文摘 | Enos P Sawatsky L H | 1981 | Journal of Sedimentary Petrology1981，63，： | 1 |
| 14 | Controls on facies architecture of a large Triassic carbonate platform: The Great Bank of Guizhou, Nanpanjiang Basin, South China 显示文摘 | Lehnnaun D J Wei Jiayong Enos P | 1998 | Journal of Sedimentary Research1998，68，： | 1 |
| 15 | Pore networks in Holoeene carbonate sedi- ments显示文摘 | Enos P Sawatsky L H | 1981 | Journal of Sedimentary Petrology1981，51，： | 1 |
| 16 | Permian and Triassic depositional history of the Yangtze Platform and Great Bank of Guizhou in the Nanpanjiang Basin of Guizbou and Guangxi, South China 显示文摘 | Lehrmmm D J Enos P Payne J L Montgomery P Wei Jiayong Yu Youyi Xiao Jiafei Orchard M J | 2005 | Albertiana2005，33，： | 1 |
| 17 | Timing of recovery from the end-Permian extinction: Geochronologic and biostratigraphic constraints from south China 显示文摘 | Lehrmann D J Rarnezani J Bowfing S A Martin M W Montgomery P Enos P Payne J L Orchard M J Wang Hongmei Wei Jiayong | 2006 | Geology2006，34，： | 1 |
| 18 | Integrated biostratigraphy, magne- tostratigraphy, and geochronolgy of the Olenekian -- Anisian boundary in marine strata of Guandao section, Nanpanjiang Basin, south Chi- na : Implications for timing of biotic recovery from the end-Permian mass extinction 显示文摘 | Wang Hongmei Xiao Jiafei Lehrmann D P Montgomery P P Enos J Orchard M Bowring S A | 2003 | North Central Section Geological Society of Ameri- ca Abstracts with Programs2003，35，2： | 1 |
| 19 | Death in Guizhou-Late Triassic drowning of the Yangtze carbonate platform显示文摘 | Enos P Wei Jiayong Lehrmann D J | 1998 | Sedimentary Geology1998，118，： | 1 |
| 20 | Pore networks in Holocene carbonate sediments显示文摘 | Enos P Sawatsky L H | 1981 | Journal of Sedimentary Petrology1981，51，： | 1 |
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