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| 1 | miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction显示文摘Although microRNAs(miRNAs) have been intensively studied in cardiac fibrosis,their roles in drug-mediated anti-fibrotic therapy are still unknown.Previously,Pioglitazone attenuated cardiac fibrosis and increased miR-711 experimentally.We aimed to explore the role and mechanism of miR-711 in pioglitazone-treated myocardial infarction in rats.Our results showed that pioglitazone significantly reduced collagen-I levels and increased miR-711 expression in myocardial infarction heart.Pioglitazone increased the expression of miR-711 in cardiac fibroblasts,and overexpression of miR-711 suppressed collagen-I levels in angiotensin II(Ang II)-treated or untreated cells.Transfection with antagomir-711 correspondingly abolished the pioglitazone-induced reduction in collagen-I levels.Bioinformatics analysis identified SP1,which directly promotes collagen-I synthesis,as the putative target of miR-711.This was confirmed by luciferase assay and western blot analysis.Additionally,increased SP1 expression was attenuated by pioglitazone in myocardial infarction heart.Furthermore,transfection of antagomir-711 attenuated pioglitazone-reduced SP1 expression in cardiac fibroblasts with or without Ang II stimulation.We conclude that pioglitazone up-regulated miR-711 to reduce collagen-I levels in rats with myocardial infarction.The miR-711-SP1-collagen-I pathway may be involved in the anti-fibrotic effects of pioglitazone.Our findings may provide new strategies for miRNA-based anti-fibrotic drug research. | ZHAO Na YU HaiYi YU HaiTao SUN Min ZHANG YouYi XU Ming GAO Wei | 2013 | Science China(Life Sciences)2013，56，5： | 9 |
| 2 | Highly Efficient Adsorption of Copper Ions by a PVP-Reduced Graphene Oxide Based On a New Adsorptions Mechanism显示文摘Polyvinylpyrrolidone-reduced graphene oxide was prepared by modified hummers method and was used as adsorbent for removing Cu ions from wastewater. The effects of contact time and ions concentration on adsorption capacity were examined. The maximum adsorption capacity of 1689 mg/g was observed at an initial p H value of 3.5 after agitating for 10 min. It was demonstrated that polyvinylpyrrolidone-reduced graphene oxide had a huge adsorption capacity for Cu ions, which was 10 times higher than maximal value reported in previous works. The adsorption mechanism was also discussed by density functional theory. It demonstrates that Cu ions are attracted to surface of reduced graphene oxide by C atoms in reduced graphene oxide modified by polyvinylpyrrolidone through physisorption processes, which may be responsible for the higher adsorption capacity. Our results suggest that polyvinylpyrrolidone-reduced graphene oxide is an effective adsorbent for removing Cu ions in wastewater. It also provides a new way to improve the adsorption capacity of reduced graphene oxide for dealing with the heavy metal ion in wastewater. | Yongji Zhang HuiJuan Chi WenHui Zhang Youyi Sun Qing Liang Yu Gu Riya Jing | 2014 | Nano-Micro Letters2014，6，1： | 9 |
| 3 | Triassic Transgressive-Regressive Sequences in Guizhou-Guangxi Region, South China显示文摘Seven third-order transgressive-regressive sequences are recognized in the Early Triassic -Early Carnian stratigraghc succession of Guizhou-Guangxi region, South China. Based on currently available ages by the correlation of conodont ammonites and bivalve faunas, these sequences range approximately from 1.0 Ma to 5.6 Ma, with the average of 3 Ma. They occur largely in the Griesbachian-Dienerian, Smithian,uppermost Smithian-lowermost Anisian, Lower Anisian, Middle Anisian, Upper Anisian-Upper Ladinian and the uppermost Ladinian-Lower Carnian respectively, and can be grouped into three second-order transgressive-regressive supersequences. A relative sea level curve is established from the sequence stratigraghic analysis. Transgressive-regressive sequences,bounded by transgressive surfaces and the correlatable unconformities, are real unconformity-bounded units of lower rank. Each sequence comprises transgressive, highstand and regressive systems tracts, and can be easily correlated with the depositional sequence. | Wei Jiayong (Regional Geological Survey, Xi’an College of Geology, Xi ’an 710054) Liao Nengmao Yu Youyi (Regional Geological Surveying Institute of Guizhou, Guiyang 550005) | 1996 | Journal of Earth Science1996，15，1： | 6 |
| 4 | In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells显示文摘 | Zhenpeng Qiu Benhong Zhou Long Jin Honglian Yu Lijuan Liu Youyi Liu Chengchen Qin Shuixiang Xie Fan Zhu | 2013 | Food and Chemical Toxicology2013，，： | 3 |
| 5 | Surface modification of PVDF porous membranes via poly (DOPA) coating and heparin immobilization显示文摘 | Zhu Liping Yu Jingzhen Xu Youyi | 2009 | Colloids and Surfaces B: Biointerfaces2009，69，： | 1 |
| 6 | Permian and Triassic depositional history of the Yangtze Platform and Great Bank of Guizhou in the Nanpanjiang Basin of Guizbou and Guangxi, South China 显示文摘 | Lehrmmm D J Enos P Payne J L Montgomery P Wei Jiayong Yu Youyi Xiao Jiafei Orchard M J | 2005 | Albertiana2005，33，： | 1 |
| 7 | Permian-Triassic boundary and a Lower-Middle Tri- assic boundary sequence on the Great Bank of Guizhou, Nanpanjiang Basin, southern Guizhou Province 显示文摘 | Lehrmann D J P Payne J L E Montgomery P Wei Jiayong Yu Youyi Orchard M J | 2005 | Albertiana2005，33，： | 1 |
| 8 | Depletion of Kindlin-2 induces cardiac dysfunction in mice显示文摘Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy(HCM) or dilated cardiomyopathy(DCM). Our previous investigation showed that Kindlin-2 is mainly localized at the Z-disc and depletion of Kindlin-2 disrupts the structure of the Z-Disc. Here, we reported that depletion of Kindlin-2 leads to the disordered myocardial fibers, fractured and vacuolar degeneration in myocardial fibers. Interestingly, depletion of Kindlin-2 in mice induced cardiac myocyte hypertrophy and increased the heart weight. Furthermore, decreased expression of Kindlin-2 led to cardiac dysfunction and also markedly impairs systolic function. Our data indicated that Kindlin-2 not only maintains the cardiac structure but also is required for cardiac function. | Lihua Qi Yu Yu Xiaochun Chi Danyu Lu Yao Song Youyi Zhang Hongquan Zhang | 2016 | Science China(Life Sciences)2016，59，11： | 1 |
| 9 | Stable carbon isotope stratigraphy across the Permian -Triassic boundary in shallow marine carbonate platforms, Nanpanjiang Basin, South China 显示文摘 | Krull E S Lehrmann D J P Drake D Kessel B P Yu Youyi Li Rongxi | 2004 | Palaeogeography Palaeoclimatology Palaeoecolo- gy2004，，34： | 1 |
| 10 | Surface modification of PVDF porous membranes via poly (DOPA) coating and heparin immobilization 显示文摘 | LiPing Zhu JingZhen Yu YouYi Xu | 2009 | Colloids and Surfaces B:Biointerfaces2009，69，1： | 1 |
| 11 | Comparison of alpha1-adrenergic receptor cell-membrane stationary phases prepared from expressed cell line and from rabbit hepatocytes显示文摘 | Yu Wang Bingxiang Yuan Xiuling Deng Langchong He Sicen Wang Youyi Zhang Qide Han | 2006 | Analytical and Bioanalytical Chemistry (-)2006，，7： | 1 |
| 12 | miR-200b suppresses cell proliferation, migration and enhances chemosensitivityin prostate cancer by regulating Bmi-1显示文摘 | Junjie Yu Youyi Lu Di Cui Enhui Li Yipin Zhu Yuyang Zhao Fujun Zhao Shujie Xia | 2014 | Oncology Reports2014，，2： | 1 |
| 13 | Comparison of alpha1-adrenergic receptor cell-membrane stationary phases prepared from expressed cell line and from rabbit hepatocytes显示文摘 | Yu Wang Bingxiang Yuan Xiuling Deng Langchong He Sicen Wang Youyi Zhang Qide Han | 2006 | Analytical and Bioanalytical Chemistry (-)2006，，7： | 1 |
| 14 | A new method to optimize the satellite broadcasting schedules using the mean field annealing of a Hopfield networks显示文摘 | EDWIN S H HOU YOUYI YU | 1995 | IEEE Transaction on Neural Networks1995，6，2： | 1 |
| 15 | Lower Triassic peritidal cyclic limestone: an example of anachronistic carbonate facies from the Great Bank of Guizhou, Nanpanjiang Basin, Guizhou province, South China显示文摘 | Daniel J Lehrmann Yang Wan Jiayong Wei YouYi Yu Jiafei Xiao | 2001 | Palaeogeography Palaeoclimatology Palaeoecology2001，，3： | 1 |
| 16 | Microturbulence in HT-6M Tokamak显示文摘The small scale density Buctuations in the interior of HT-6M Ohmic plasma have been studied by CO_(2) laser collective scattering system in deuterium discharges covering a range of neQa(chord-average density times safety factor at the limiter)and energy confinement time.Tlie relative density fluctuation level in the interior is inversely proportional to the toroidal magnetic field and average densityt and the energy con・fineineiit time te decreases with the Huctuation level increasing in the region where te linearly increases with neqa and satisfies the Goldston scaling law.It is suggested that the niicroturbulence in the interior zone is responsible for anomalous transport in tokamaks. | ZENG Lei YU Changxuan CAO Jinxiang ZHU Guoliang ZHANG Daqing LI Youyi | 1993 | Chinese Physics Letters1993，10，8： | 0 |
| 17 | Protocol for a randomized controlled trial of electroacupuncture in the management of patients with axial spondyloarthritis in Singapore(E-AcuSpA)显示文摘Background:Despite therapeutic advances,treatment of patients with axial spondyloarthritis(axSpA)continue to pose as a challenge as many do not respond well to conventional Western medications,such as nonsteroidal anti-inflammatory drugs(NSAIDs)and biologic diseasemodifying antirheumatic drugs(bDMARDs).Hence,acupuncture is a possible alternative.Some studies found electroacupuncture to be better than manual acupuncture,though no trials have been conducted in patients with axSpA.This clinical trial aims to evaluate the clinical efficacy,safety,and cost-effectiveness of electroacupuncture compared to manual acupuncture for patients with axSpA.Methods/Design:This randomized controlled trial will recruit 100 patients diagnosed with axSpA,who have active disease despite NSAIDs and bDMARDs.Eligible patients will be randomized to receive either electroacupuncture or manual acupuncture in a 1:1 ratio.All participants will receive standard rheumatologic care in addition to 20 acupuncture sessions.The mean difference in Bath Ankylosing Spondylitis Disease Activity Index score between the 2 groups over 12 weeks will serve as the primary outcome.Secondary outcomes include improvements in other clinical,quality of life,and economic outcomes over 24 weeks.All adverse events will be recorded.Discussion:Results from this trial may provide evidence regarding the clinical effectiveness,safety,and cost-effectiveness of electroacupuncture compared to manual acupuncture for patients with axSpA,and guide implementation into clinical practice.Limitations of this trial include the lack of patient blinding,use of a repeated measures design,and possible variation in acupuncture technique amongst the various Traditional Chinese Medicine practitioners. | Warren Fong Yu Heng Kwan Su-An Quek Ader Lim Chiah Yuen Wong Shin Yoong Chua Hui Chin Tan Clara Eng Choy Tip Tan Bao Qiang Dong Youyi Huang Chuen Seng Tan Bee Choo Tai Ting Hui Woon Jie Kie Phang Hwee Ling Koh Ying Ying Leung Julian Thumboo TrulsØstbye | 2021 | Rheumatology & Autoimmunity2021，1，2： | 0 |
| 18 | Exercise training attenuates angiotensinⅡ-induced cardiac fibrosis by reducing POU2F1 expression显示文摘Background:Exercise training protects against heart failure.However,the mechanism underlying the protective effect of exercise training on angiotensinⅡ(AngⅡ)-induced cardiac fibrosis remains unclear.Methods:An exercise model involving C57BL/6N mice and 6 weeks of treadmill training was used.AngⅡ(1.44 mg/kg/day)was administered to induce cardiac fibrosis.RNA sequencing and bioinformatic analysis were used to identify the key factors mediating the effects of exercise training on cardiac fibrosis.Primary adult mouse cardiac fibroblasts(CFs)were used in vitro.Adeno-associated virus serotype 9 was used to overexpress POU domain,class 2,transcription factor 1(POU2F1)in vivo.Results:Exercise training attenuated AngⅡ-induced cardiac fibrosis and reversed 39 gene expression changes.The transcription factor regulating the largest number of these genes was POU2F1.Compared to controls,POU2F1 was shown to be signififcantly upregulated by AngⅡ,which is itself reduced by exercise training.In vivo,POU2F1 overexpression nullified the benefits of exercise training on cardiac fibrosis.In CFs,POU2F1 promoted cardiac fibrosis.CCAAT enhancer-binding proteinβ(C/EBPβ)was predicted to be the transcription factor of POU2F1and verified using a dual-luciferase reporter assay.In vivo,exercise training activated AMP-activated protein kinase(AMPK)and alleviated the increase in C/EBPβinduced by AngⅡ.In CFs,AMPK agonist inhibited the increase in C/EBPβand POU2F1 induced by Ang II,whereas AMPK inhibitor reversed this effect.Conclusion:Exercise training attenuates AngⅡ-induced cardiac fibrosis by reducing POU2F1.Exercise training inhibits POU2F1 by activating AMPK,which is followed by the downregulation of C/EBPβ,the transcription factor of POU2F1. | Na Feng Haiyi Yu Yueshen Wang Youyi Zhang Han Xiao Wei Gao | 2023 | Journal of Sport and Health Science2023，12，4： | 0 |
| 19 | Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic,histological,and urine analysis显示文摘While doxorubicin(DOX)is one of the most common chemotherapeutic drugs for treating cancer,use of DOX must be managed carefully due to dose-related toxicity.Nanodiamond(ND)drug delivery system conjugated with DOX(NDX)has been reported to enhance treatment efficacy and attenuate toxicity in murine cancer models.In addition,extensive biocompatibility studies indicate that NDs seem to be well tolerated in non-human primates.Before the clinical translation of NDX,it is necessary to verify the safety of ND in large mammals.Studies of nanomedicine drug safety for large animal are not commonly reported,and this work represents a key milestone in bridging earlier advances towards clinical assessment.Herein,NDs’safety as a drug-delivery platform was evaluated in Naïve Beagle dogs.The study is performed with DOX,ND,and NDX in a dual-gender animal model using intravenous(IV)injection and hepatic portal vein(HPV)injection methods.The dogs are monitored for their health phenotype changes in continuous 5 days.Blood and urine obtained are for clinical pathology research.The results indicate that ND drug delivery platform significantly relieves DOX toxicity for Naïve Beagle dog model.This study provides guidance for the pre-clinical safety assessment of NDX therapy at large animal level. | Liping Wang Wenqiong Su Khan Zara Ahmad Xin Wang Ting Zhang Youyi Yu Edward Kai-Hua Chow Dean Ho Xianting Ding | 2022 | Nano Research2022，15，4： | 0 |
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