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| 1 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 2 | Pharmacological effects of lipid-lowering drugs on circulating adipokines显示文摘The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines.Adipokines influence energy homeostasis and metabolism and have also been shown to modulate the vascular inflammatory cascade.The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs(statins,fibrates,niacin and omega-3-fatty acids) on the circulating concentrations of leptin,adiponectin,tumor necrosisfactor-α(TNF-α),Retinol binding protein 4(RBP4) and resistin.Overall,the lipid-lowering drugs reviewed have minimal effects on leptin and resistin concentrations.Conversely,circulating adiponectin concentrations are consistently increased by each lipid-lowering drug reviewed with the greatest effects produced by niacin.Studies that have examined the effects of statins,niacin and omega-3-fatty acids on TNF-α demonstrate that these agents have little effect on circulating TNF-α concentrations.Niacin and fibrates appear to lower RBP4 but not resistin concentrations.The results of the available studies suggest that a strong relationship exists between pharmacological reductions in blood lipids and adiponectin that is not obvious for other adipokines reviewed. | Desiree Wanders Eric P Plaisance Robert L Judd | 2010 | World Journal of Diabetes2010，1，4： | 5 |
| 3 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 4 | Phytoremediation of soil metals显示文摘 | Rufus L Chaney Minnie Malik Yin M Li Sally L Brown Eric P Brewer J Scott Angle Alan JM Baker | 1997 | Current Opinion in Biotechnology1997，，3： | 2 |
| 5 | Conflict Resolution Problems for Air Traffic Management System Solved with Mixed Integer Programming显示文摘 | Eric M L P | 2002 | IEEE Transaction on Intelligent Transportation Systems2002，3，1： | 2 |
| 6 | Exploratory bioavailability and pharmacokinetic studies of sulphadime-thoxine and ormetoprim in the penaeid shrimp, Penaeus vannamei 显示文摘 | Eric D P Donald V L Nicholas M | 1995 | Aquaculture1995，130，： | 1 |
| 7 | Phosphorus diagenesis in lake sediments:investigation using fractionation techniques显示文摘 | Michael R P Martin T A Eric L V | 1995 | Mar Freshwater Res1995，46，： | 1 |
| 8 | Genetic diversity among witchhazel cultivars based on Randomly Amplified Polymorphic DNA markers显示文摘 | Robert D Marquard Eric P Davis Emily L Stowe | 1997 | J Amer Soc Hort Sci1997，122，4： | 1 |
| 9 | Predicting mechanical distortions in X-ray masks显示文摘 | Eric P Cotte R L Engelstad E G Lovell | 1999 | Proc SPIE1999，3676，： | 1 |
| 10 | Managing Stake- holder Interests in E-Government Implementation: Lessons Learned from a Singapore E-Government Pro-ject显示文摘 | Chee-Wee T Shan L P Eric T K L | 2007 | International Journal of Electronic Government Research2007，3，1： | 1 |
| 11 | Startup and operation of a supercritical carbon dioxide Brayton cycle 显示文摘 | Eric M C Timothy L C Christopher P S | 2014 | Journal of Engineering for Gas Turbines and Power2014，136，： | 1 |
| 12 | Multispectral bilateral video fusion显示文摘 | Eric P John L Leonard M | 2007 | IEEE Trans on Image Proc2007，16，5： | 1 |
| 13 | Elevated temperature Mg-Al-Sr: creep resistance, mechanical properties, and micro- strueture显示文摘 | ERIC B PIERRE L MIHRIBAN O P | 2003 | JOM2003，11，： | 1 |
| 14 | Nickel and cobalt sorption on anaerobic granular sludges:kinetic and equilibrium studies显示文摘 | Hullebusch Eric D V Zandvoort M H Lens P N L | 2004 | Journal of Chemical Technology and Biotechnology2004，79，： | 1 |
| 15 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 16 | Caspases and programmed cell death in the hypersensitive response of plants to pathogens显示文摘 | OLGA D P ERIC L | 1998 | Current Biology1998，8，： | 1 |
| 17 | Assessing sediment removal capacity of vegetated and non vegetated settling ponds in prawn farms显示文摘 | Halmar H Peter V R Eric L P | 2003 | Aquacultural Engineering2003，27，： | 1 |
| 18 | Explorato- ry bioavailability and pharmacokinetie studies of sulph- adimethoxine and ormetoprim in the penaeid shrimp, Penaens vannamei 显示文摘 | Eric D P Donald V L Nicholas M | 1995 | Aquaculture1995，130，2： | 1 |
| 19 | Miniaturized gas ionization sensors using carbon nanotubes显示文摘 | MODI A KORATKAR N ERIC L WEI B Q AJAYAN P M | 2003 | Nature2003，424，： | 1 |
| 20 | Surface soil moisture parameterization of the VIC-2L model : Evaluation and modification 显示文摘 | Xu L Eric F W Dennis P L | 1996 | Global Planet Change1996，13，： | 1 |
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