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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Expression of p27 and Ki-67 in benign and malignant thyroid tumors 显示文摘 | Erick son LA Lin L Wo||an PC eta| | 1998 | Pathol1998，11，2： | 1 |
| 3 | Characterization of Damaged Skin by Imedance Spec- troscopy: Mechanical Damage 显示文摘 | White Erick A Orazem Mark E Bunge Annette L | 2013 | Pharmaceutical Research2013，30，8： | 1 |
| 4 | Placenta percreta with bladder invation managed by arterial embolization and manual removal after cesarean显示文摘 | Gerome D Erick C Ebticem L | 2000 | Obstet Gynecol2000，96，： | 1 |
| 5 | Placenta percreta with bladder invation managed by arterial embolization and manual removal after cesarean显示文摘 | Gerome D Erick C Ebticem L | 2000 | Obstet Gynecol2000，96，： | 1 |
| 6 | The Decoupling of Value Creation from Revenue:A Strategic Analysis of the Markets for Pure Information Goods显示文摘 | Karl R L | 2003 | Journal of Information Technology and Management2003，，4： | 1 |
| 7 | Employee stock options in compensation agreements: A financing explanation 显示文摘 | HOUAND L C ERICK M E | 2006 | Journal of corpo- rate finance2006，12，2： | 1 |
| 8 | Effects of leuprolide-induced hypogonadism and testosterone replacement on sleep,melatonin,and prolacfin secretion in men显示文摘 | Peter J S Erick H T | 1997 | J Clin Endocrinol Metab1997，82，10： | 1 |
| 9 | Imiquimod cream efficacy in the treatment of periocular nodular basal cell carcinoma: a non- randomized trial 显示文摘 | Erick M Rachel C Patricia L | 2015 | BMC Ophthalmol2015，15，1： | 1 |
| 10 | Bacillus subtilis spore inactivation in water using photo-assisted Fenton reaction 显示文摘 | ERICK R B ROBERTO P ANGELE V L | 2011 | Sustain En- viron Res2011，21，5： | 1 |
| 11 | A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease 显示文摘 | Marie L Chantal P Erick S | 2007 | European Heart Journal2007，28，14： | 1 |
| 12 | Experimental comparison study of control architectures for bilateral teleoperators显示文摘 | ERICK J RODRIGUEZ-SEDA M W S DONGJUN L | | 0，，6： | 1 |
| 13 | P27^kipl:a multifunctionalcyclin-dependent Kinase inhibitor with prognostic significance in humancancers显示文摘 | Llogd RV Erick son LA Jin L | 1999 | Am J Pathol1999，154，3： | 1 |
| 14 | A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease显示文摘 | Marie L Chantal P Erick S | 2007 | Eur Heart J2007，28，： | 1 |
| 15 | Placenta percreta with bladder invation managed by arterial embolization and manual removal after cesarean 显示文摘 | Gerome D Erick C Ebticem L | 2000 | Obstet Gynecol2000，96，3： | 1 |
| 16 | Wind effects on leaf mor- phology for the mangrove Conocrpus erecta at an oceanic island from the Mexican Pacific Ocean显示文摘 | ERICK D L HARTMUT S W | 2006 | Revista Chilena De Historia Natural2006，79，4： | 1 |
| 17 | A comparison of six major platelet function tests todetermine the prevalence of aspirin resistance inpatients with stable coronary artery disease显示文摘 | Marie L Chantal P Erick S | 2007 | European Heart Journal2007，28，14： | 1 |
| 18 | Crystallographic characterization and structural analysis of the first organic functionalization product of the endohedral fullerene Sc3N @ C6o 显示文摘 | Hon M L Marilyn M O Erick L | 2002 | J Am Chem Soc2002，124，： | 1 |
| 19 | Placenta perereta with bladder invation managed by arterial embolzation and manual removal after cesarean显示文摘 | Gerome D Erick C Ebticem L | 2000 | Obstet Gynecol2000，96，： | 1 |
| 20 | Glucocorticoid- induced oste- oporosis: a review 显示文摘 | B6atrice B Erick L Maurice A | 2010 | Clinic Rev Bone Miner Metab2010，8，： | 1 |
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