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| 1 | Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer显示文摘AIM: To evaluate how Helicobacter pylori(H. pylori) is able to evade the immune response and whether it enhances systemic immune tolerance against colorectal cancer.METHODS: This prospective randomized study involved 97 consecutive colorectal cancer patients and 108 cancer-free patients with extra-digestive diseases. Colorectal cancer and cancer-free patients were assigned into subgroups according to H. pylori Ig G seropositivity. Exposure to H. pylori was determined by Ig G seropositivity which was detected by enzyme linked immunoassay(ELISA). Serum neopterin levels were measured by ELISA. Serum tryptophan, kynurenine, and urinary biopterin concentrations were measured by high performance liquid chromatography. Serum nitrite levels were detected spectrophotometrically. Serum indoleamine 2,3-dioxygenase activity was estimated by the kynurenine to tryptophan ratio and by assessing the correlation between serum neopterin concentrations and the kynurenine to tryptophan ratio. The frequencies of increased serum kynurenine to tryptophan ratio of H. pylori seronegative and seropositive colorectal cancer subgroups were estimated by comparing them with the average kynurenine to tryptophan ratio of H. pylori seronegative tumor-free patients.RESULTS: Compared with respective controls, in both H. pylori seronegative and seropositive colorectal cancer patients, while serum tryptophan levels were decreased(controls vs patients; seronegative: 20.37 ± 0.89 μmol/L vs 15.71 ± 1.16 μmol/L, P < 0.05; seropositive: 20.71 ± 0.81 μmol/L vs 14.97 ± 0.79 μmol/L, P < 0.01) the kynurenine to tryptophan ratio was significantly increased(controls vs patients; seronegative: 52.85± 11.85 μmol/mmol vs 78.91 ± 8.68 μmol/mmol, P < 0.01, seropositive: 47.31 ± 5.93 μmol/mmol vs 109.65 ± 11.50 μmol/mmol, P < 0.01). Neopterin concentrations in cancer patients were significantly elevated compared with controls(P < 0.05). There was a significant correlation between serum neopterin levels and kynurenine/tryptophan in control and colorectal cancer patients groups(r s = 0.494, P = 0.0001 and r s= 0.293, P = 0.004, respectively). Serum nitrite levels of H. pylori seropositive cancer cases were significantly decreased compared with seropositive controls(controls vs patients; 26.04 ± 2.39 μmol/L vs 20.41 ± 1.48 μmol/L, P < 0.05) The decrease in the nitrite levels of H. pylori seropositive cancer patients may be attributed to excessive formation of peroxynitrite and other reactive nitrogen species.CONCLUSION: A significantly high kynurenine/tryptophan suggested that H. pylori may support the immune tolerance leading to cancer development, even without an apparent upper gastrointestinal tract disease. | Ayse Basak Engin Bensu Karahalil Ali Esat Karakaya Atilla Engin | 2015 | World Journal of Gastroenterology2015，21，12： | 11 |
| 2 | Tibialis posterior tendon abnormalities in feet with accessory navicular bone and flatfoot显示文摘 | Esat Kiter Namik Erdag Vasfi Karatosun Izge Gunal | 1999 | Acta Orthopaedica1999，，6： | 2 |
| 3 | Links between climate and sea levels for the past three million years 显示文摘 | Lambeck K Esat T M Potter E K | 2002 | Nature2002，419，： | 1 |
| 4 | Links between cli-mate and sea levels for the past three million years 显示文摘 | Lambeck K Esat T M Potter E K | 2002 | Nature2002，419，6903： | 1 |
| 5 | Reconciliaion of late Quaternary sea levels derived from coral terraces at Huon Peninsula with deep sea oxygen isotope records显示文摘 | Chappell J Omura A Esat T | 1996 | Earth and Planetary Science Letters1996，141，1234： | 1 |
| 6 | Coupled climate and sea-level changes deduced from Huon Peninsula coral terraces of the Last Ice Age显示文摘 | Yokoyama Y Esat T M Lambeck K | 2001 | Earth and Planetary Science Letters2001，193，： | 1 |
| 7 | Reeonciliaion of late Quaternary sea levels derived from coral terraces at Huon Peninsula with deep sea oxygen isotope records显示文摘 | Chappell J Omra A Esat T | 1996 | Earth and Planetary Science Letters1996，141，14： | 1 |
| 8 | Reconcihation of late Quaterna- ry sea levels derived from coral terraces at Huon Peninsula with deep sea oxygen isotope records显示文摘 | Chappell J Omura A Esat T | 1996 | Earth and Planetary Science Letters1996，141，： | 1 |
| 9 | Salmonella serotypes isolated from chicken meat in Albania显示文摘 | Elvira Beli Esat Duraku Altin Telo | 2001 | International Journal of Food Microbiology2001，71，2： | 1 |
| 10 | Artificial neural network based fault diagnosis of rotating machinery using wavelet transforms as processor显示文摘 | Paya A Esat I I Badi M N M | 1997 | Mechanical Systems and Signal Processing1997，11，5： | 1 |
| 11 | Effect of penicillin G-induced epileptic seizures on hemorheological parameters in rats 显示文摘 | Esat Ad~giizel Vural Kiiqiikatay Gtllten Erken | 2006 | Life Sciences2006，79，25： | 1 |
| 12 | Surface alignment based on the moment of inertia and improved least-squares methods显示文摘 | ESAT I I BAHAI H | 2000 | Journal of Engineering Manufacture2000，214，7： | 1 |
| 13 | The persistence of off-cratonic lithospheric mantle:Os isotopic systematics of variably metasomatised Southeast Australian xenoliths显示文摘 | Bennett V C Esat T M | 1997 | Earth and Planetary Science Letters1997，151，12： | 1 |
| 14 | A new approach to time-domain vibration condition monitoring:Gear tooth fatigue crack detection and identification by the Kolmogorov-Smirnov test显示文摘 | Andrade F A Esat I Badi M N M | 2001 | Journal of Sound and Vibration2001，240，5： | 1 |
| 15 | The effects of various pulping conditions on crystalline structure of cellulose in cotton linters显示文摘 | Esat G M Mustafa U Huseyin K | 2003 | Polymer Degradation and Stability2003，，81： | 1 |
| 16 | Artificial neural network based on fault diagnostics of rotating machinery using wavelet transforms as a preprocessor显示文摘 | Paya B A Esat I I | 1997 | Mechanical Systems and Signal Processing1997，11，5： | 1 |
| 17 | A new approach to time-domain vibration condition monitoring: Gear tooth fatigue crack detection and identification by the Kolmogorov-Smirnov 显示文摘 | ANDRADE F A ESAT I BADI M N M | 2001 | Journal of Sound and Vibration2001，240，5： | 1 |
| 18 | Reconciliation of late Quaternary sea level derived from coral terraces at Huon Peninsula with deep-sea oxygen isotope records显示文摘 | Chappell J Omura A Esat T | 1996 | Earth and Planetary Science Letters1996，141，： | 1 |
| 19 | Finite element analysis of springback in bending of aluminium sheets 显示文摘 | ESAT V DARENDELILER H GOKLER M I | 2002 | Materials and Design2002，23，2： | 1 |
| 20 | High-precision U-series dating of corals from Western Australia and implications for the timing and duration of the last interglacial显示文摘 | Stirling C H Esat T M McCulloch M T | | 0，，： | 1 |
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