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| 1 | Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells显示文摘免疫球蛋白 E (IgE ) 在过敏气喘起一个关键作用并且是为 monoclonal 抗体的一个临床上验证的目标。治疗学的 anti-IgE 抗体块在 IgE 和 Fc epsilon 之间的相互作用(Fcε) 受体,它消除或最小化,但是做过敏显型不典型地由 B 房间削减 IgE 的进行中的生产。我们产生了有潜力抵销可溶的 IgE 并且通过抗体依赖者消除表示 IgE B 房间的高亲密关系的 anti-IgE 抗体(MEDI4212 ) 调停房间的 cytotoxicity。MEDI4212 变体被产生在 fucosylation 在抗体或改变的 Fc 区域包含变化以便为 Fcγ 提高抗体亲密关系; RIIIa。所有 MEDI4212 变体与比得上的亲密关系跳了到人的 IgE 野类型(WT ) 抗体。每变体被显示禁止在 IgE 和 Fcε 之间的相互作用; RI,它翻译了成 Fcγ 的有势力抑制;调停 RI 的功能回答。重要地,所有变体在表示房间的膜 IgE 的表面同样跳了到 IgE。然而, MEDI4212 变体为 Fcγ 表明了提高的亲密关系;包括在位置 158 点的多态的变体的 RIIIa。在 Fcγ 的改进;导致的 RIIIa 绑定在用两个都设计的房间线和类的基于的试金交换了的房间增加了受动器功能人的 IgE B 房间。通过它 IgE 的优异抑制,我们预计那受动器功能提高了 MEDI4212 也许能抵销可溶的 IgE 的高水平并且在他们区分并且变得 IgE secreting 血浆房间以前,由消除表示 B 房间的 IgE 提供增加的长期的利益。 | Andrew C. Nyborg Anna Zacco Rachel Ettinger M. Jack Borrok Jie Zhu Tom Martini Rob Woods Christine Kiefer Michael A. Bowen E. Suzanne Cohenz Ronald Herbst Herren Wu Steven Coats | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 2 | Patients with type 2 diabetes demonstrate proprioceptive deficit in the knee显示文摘AIM To investigate proprioceptive discrepancies in the lower extremity in persons with type 2 diabetes mellitus(T2DM). METHODS In this cross-sectional study, a total of 46 older persons were divided into a T2DM group(n = 23) and a control group who did not have T2 DM(n = 23). Participants were given a brief warm up with stretching exercises. Diabetic neuropathy scores were collected prior to proprioceptive testing. For proprioceptive testing, participants performed leg extensions to randomized target positions of 15°, 30°, 45, 60° degrees of elevation in the sagittal plane, each target was repeated a total of four times. Subjects were guided to target positions in the absence of visual feedback via auditory cues from a custom JPS application. When the participant entered the target position, they memorized the location of their limb in space and subsequently attempted to relocate this position in space. Proprioceptive errors were measured from the target positioned, target remembered, target repositioned protocol. RESULTS Proprioceptive accuracy was lower in the diabetic groupat all levels of target angle than the control group(P < 0.05). The diabetic group had 46% greater inaccuracy than the control group at all levels of target position. Diabetics also reported greater neuropathy scores than controls in the past 12 mo P < 0.01. CONCLUSION Deficits in lower limb localization and greater diabetic neuropathy scores were identified in this study. Our findings may be associated with deafferentation as peripheral neuropathy is a common complication with the disease. These findings may help to explain the declining balance function in the older persons with T2DM which is also commonly reported. | Lucas Richard Ettinger Ami Boucher Elisabeth Simonovich | 2018 | World Journal of Diabetes2018，9，3： | 2 |
| 3 | 老年高胆固醇血症的诊断和治疗显示文摘冠心病(CHD)是65岁以上老年人病残及死亡的主要原因。引起CHD的危险因素有多种,本文主要讨论CHD的重要危险因素——高胆固醇血症,以及老年人的高胆固醇血症的治疗。治疗中首先应考虑患者的年龄、性别及健康状况,再进行膳食和药物治疗。 | Ettinger WH 钱方毅 | 1991 | 国外医学(老年医学分册)1991，12，2： | 2 |
| 4 | Concurrent hyperfractionated irradiation and chemotherapy for unresectable non-small-cell lung cancer:results of radiation therapy oncology group 90-15显示文摘 | Byhardt RW Scott CB Ettinger DS | 1995 | Cancer1995，75，： | 1 |
| 5 | Multidisciplinary management of lung cancer显示文摘 | SPIRA A ETTINGER D S | 2004 | N Engl J Med2004，350，4： | 1 |
| 6 | Is there a preferred combination chemotherapy regimen for metastastic non-small cell lung cancer?显示文摘 | Ettinger DS | 2002 | Oncologist2002，7，3： | 1 |
| 7 | Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study 显示文摘 | Ettinger MP Littlejohn TW Schwartz SL | 2003 | J American Med Associ2003，289，14： | 1 |
| 8 | Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia显示文摘 | Dujovne CA Ettinger MP McNeer JF | 2002 | Am J Cardiol2002，90，10： | 1 |
| 9 | 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update)显示文摘 | Hani Jneid Jeffrey L. Anderson R. Scott Wright Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2012 | Journal of the American College of Cardiology2012，，7： | 1 |
| 10 | Non-small cell lung cancer显示文摘 | Ettinger DS | 2010 | J Natl Compr Canc Netw2010，8，7： | 1 |
| 11 | Multidisciplinary management of lung cancer显示文摘 | Spira A Ettinger DS | 2004 | N Engl J Med2004，350，： | 1 |
| 12 | Multidisciplinary management of lung cancer显示文摘 | Spira A Ettinger DS | 2004 | N Engl J Med2004，350，4： | 1 |
| 13 | New drugs for chemotherapy-naive patients with etensire-disease small cell lung cancer显示文摘 | Ettinger D S | 2008 | Semin Oncol2008，28，： | 1 |
| 14 | Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence显示文摘 | Ettinger SL Sobel R Whitmore TG | 2004 | Cancer Res2004，64，6： | 1 |
| 15 | Beta 57-Asp plays an essential role in the unique SDS stability of HLADQA1 * 0201/ DQB1 * 0602 alpha beta protein dimmer,the class Ⅱ MHC allele associated with protection from insulin-dependent diabetes mellitus 显示文摘 | Ettinger R A Liu A W Nepom G T | 2000 | J Immunol2000，165，： | 1 |
| 16 | Downstream signalling events regulated by phosphatidylinositol 3-kinase activity 显示文摘 | Duronio V Scheid MP Ettinger S | 1998 | Cell Signalling1998，10，： | 1 |
| 17 | The association of radiographically detected vertebral fractures with back pain and function: a prospective study显示文摘 | Nevitt MC Ettinger B Black DM | 1998 | Ann Intern Med1998，128，： | 1 |
| 18 | The role of IL-21 in regu- lating B-cell function in health and disease显示文摘 | Ettinger R Kuehen S Lipsky PE | 2008 | Immunol F:ev2008，223，7： | 1 |
| 19 | Lung cancer screening显示文摘 | Wood DE Eapen GA Ettinger DS | 2012 | J Natl Compr Canc Netw2012，10，2： | 1 |
| 20 | 2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction显示文摘 | R. Scott Wright Jeffrey L. Anderson Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats Hani Jneid A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2011 | Journal of the American College of Cardiology2011，，19： | 1 |
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