|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-surgical treatment of post-surgical bile duct injury: Clinical implications and outcomes显示文摘AIM:To investigate the prognostic factors determining the success rate of non-surgical treatment in the management of post-operative bile duct injuries(BDIs).METHODS:The study patients were enrolled from the pancreatobiliary units of a tertiary teaching hospital for the treatment of BDIs after hepatobiliary tract surgeries,excluding operations for liver transplantation andmalignancies,from January 1999 to August 2010.A total of 5167 patients underwent operations,and 77patients had BDIs following surgery.The primary end point was the treatment success rate according to different types of BDIs sustained using endoscopic or percutaneous hepatic approaches.The type of BDI was defined using one of the following diagnostic tools:endoscopic retrograde cholangiography,percutaneous transhepatic cholangiography,computed tomography scan,and magnetic resonance cholangiography.Patients with a final diagnosis of BDI underwent endoscopic and/or percutaneous interventions for the treatment of bile leak and/or stricture if clinically indicated.Patient consent was obtained,and study approval was granted by the Institutional Review Board in accordance with the legal regulations of the Human Clinical Research Center at the Seoul National University Hospital in Seoul,South Korea.RESULTS:A total of 77 patients were enrolled in the study.They were divided into three groups according to type of BDI.Among them,55 patients(71%)underwent cholecystectomy.Thirty-six patients(47%)had bile leak only(type 1),31 patients had biliary stricture only(type 2),and 10 patients had both bile leak and biliary stricture(type 3).Their initial treatment modalities were non-surgical.The success rate of non-surgical treatment in each group was as follows:BDI type 1:94%;type 2:71%;and type 3:30%.Clinical parameters such as demographic factors,primary disease,operation method,type of operation,non-surgical treatment modalities,endoscopic procedure steps,type of BDI,time to diagnosis and treatment duration were evaluated to evaluate the prognostic factors affecting the success rate.The type of BDI was a statistically significant prognostic factor in determining the success rate of non-surgical treatment.In addition,a shorter time to diagnosis of BDI after the operation correlated significantly with higher success rates in the treatment of type 1 BDIs.CONCLUSION:Endoscopic or percutaneous hepatic approaches can be used as an initial treatment in type1 and 2 BDIs.However,surgical intervention is a treatment of choice in type 3 BDI. | Young Ook Eum Joo Kyung Park Jaeyoung Chun Sang-Hyub Lee Ji Kon Ryu Yong-Tae Kim Yong-Bum Yoon Chang Jin Yoon Ho-Seong Han Jin-Hyeok Hwang | 2014 | World Journal of Gastroenterology2014，20，22： | 7 |
| 2 | Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial显示文摘Background: Controlled-release oxycodone/naloxone(OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone(OX-CR) for the control of cancer-related pain in Korean patients.Methods: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale(NRS) pain score ≥4] from seven Korean oncology/hematology centers. Patients in the intention-to-treat(ITT) population were randomized(1:1) to OXNCR or OX-CR groups. OXN-CR was administered starting at 20 mg/10 mg per day and up-titrated to a maximum of80 mg/40 mg per day for 4 weeks, and OX-CR was administered starting at 20 mg/day and up-titrated to a maximum of 80 mg/day for 4 weeks.The primary efficacy endpoint was the change in NRS pain score from baseline to week4, with non-inferiority margin of-1.5. Secondary endpoints included analgesic rescue medication intake, patientreported change in bowel habits, laxative intake, quality of life(QoL), and safety assessments.Results: Of the ITT population comprising 128 patients, 7 with missing primary efficacy data and 4 who violated the eligibility criteria were excluded from the efficacy analysis. At week 4, the mean change in NRS pain scores was not significantly different between the OXN-CR group(n = 58) and the OX-CR group(n = 59)(-1.586 vs.-1.559,P = 0.948). The lower limit of the one-sided 95% confidence interval(-0.776 to 0.830) for the difference exceeded the non-inferiority margin(P < 0.001). The OXN-CR and OX-CR groups did not differ significantly in terms of analgesic rescue medication intake, change in bowel habits, laxative intake, QoL, and safety assessments.Conclusions: OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatment and had a similar safety profile. Studies in larger populations of Korean patients with cancer-related pain are needed to further investigate the effectiveness of OXN-CR for long-term pain control and constipation alleviation.Trial registration ClinicalTrials.gov NCT01313780, registered March 8。 | Kyung-Hee Lee Tae Won Kim Jung-Hun Kang Jin-Soo Kim Jin-Seok Ahn Sun-Young Kim Hwan-Jung Yun Young-Jun Eum Sung Ae Koh Min Kyoung Kim Yong Sang Hong Jeong Eun Kim Gyeong-Won Lee | 2017 | Chinese Journal of Cancer2017，36，11： | 4 |
| 3 | Prediction of response to entecavir therapy in patients with HBeAg‐positive chronic hepatitis B based on on‐treatment HBsAg, HBeAg and HBV DNA levels显示文摘 | J. W. Shin S. W. Jung B. R. Park C. J. Kim J. B. Eum B. G. Kim I. D. Jeong S.‐J. Bang S.‐H. Lee S. R. Kim N. H. Park | 2012 | Journal of Viral Hepatitis2012，，10： | 3 |
| 4 | Desalination of a thermal power plant wastewater by membrane capacitive deionization显示文摘 | Jae-Bong Lee Kwang-Kyu Park Hee-Moon Eum Chi-Woo Lee | 2006 | Desalination2006，，1： | 2 |
| 5 | 中国延吉市和南朝鲜江华岛朝鲜族精神障碍终生患病率的比较研究显示文摘本文采用DIS-Ⅲ朝鲜文版诊断性面谈工具,按着美国流行学集合区域研究(ECA)方法在中国吉林省延吉市和南朝鲜江华岛以随机整群方法对朝鲜族分别进行了精神科流行学调查。延吉市样本为1532名,江华岛为1450名。精神障碍的终生患病率如下: (1) 居民终生患病率中频度最高的前三位是在江华岛,酒使用障碍(26.77%)、病理性赌博(6.28%)、焦虑症(5.95%);在中国,酒使用障碍(18.46%)、焦虑症(5.71%)、恐怖症(4.57%)。 (2) 两个地区的酒使用障碍皆为男性高于女性,男女两性之比:江华岛,49.4%比2.9%,延吉市,36.89%比0.12%。两个地区焦虑症和抑郁症患病率皆为女性高于男性,延吉市女性恐怖症高于男性。 (3) 患病率高峰:两个地区的焦虑症、抑郁性神经症患病率高峰见于高年龄组,在江华岛抑郁症、强迫症高峰见于低年龄组,精神发育迟滞高峰见于高年龄组;在延吉市病理性赌博高峰见于低年龄组,洒使用障碍、强迫症高峰见于高年龄组。 (4) 两个地区既婚者患病率高于未婚者。 (5) 两个地区高学历组的酒使用障碍患病率高,低学历组焦虑症患病率高;在江华岛抑郁性神经症和精神发育迟滞的患病率高峰见于低学历组。 (6) 除恐怖症、强迫症以外,其余精神障碍的患病率,在江华岛高于延吉市。 (7) 本文终身患病率与其他地区的ECA资料比较,除酒使用障碍以外。 | 李东根 方文贤 沈昌权 金元福 李胜富 李千石 朴永万 李镐荣 Eum sul Lee Robert Roberts | 1990 | 延边医学院学报1990，13，2： | 2 |
| 6 | Extended Methods for Identifying Dominance and Potential Optimality in Multi - criteria Analysis with Imprecise Information显示文摘 | Lee K S Park K S Eum Y S | 2001 | European Journal of Operational Research2001，134，3： | 1 |
| 7 | Transduction of Cu,Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells显示文摘 | Kwon HY Eum WS Jang HW | 2000 | FEBS Lett2000，485，23： | 1 |
| 8 | Extended methods for identifying dominance and potential optimality in multicriteria analysis with imprecise information显示文摘 | Lee K S Park K S Eum Y S | | 0，，03： | 1 |
| 9 | Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reper- fusion in rats 显示文摘 | Kim SJ Eum HA Billiar TR | 2013 | Shock2013，39，4： | 1 |
| 10 | Extended methods for identifying dominance and potential optimality in multicriteria analysis with imprecise information 显示文摘 | LEE K S PARK K S EUM Y S ET AL | 2001 | European Journal of Operational Research2001，134，3： | 1 |
| 11 | VEGF regulates PCB 104 mediated stimulation ofperineability and transmigration of breast cancer cells in human mi-crovascular endothelial cells显示文摘 | Eum SY Iee YW | 2004 | Exp Cell Res2004，296，2： | 1 |
| 12 | Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells显示文摘 | Jin LH Bahn JH Eum WS | 2001 | Free Radic Biol Med2001，31，11： | 1 |
| 13 | Necrosis and apoptosis:sequence of liver damage following reperfusion after 60 min ischemia in rats显示文摘 | Eum HA Cha YN Lee SM | 2007 | Biochem Biophys Res Commun2007，358，2： | 1 |
| 14 | 1-Hydroxypyrene as a biomarker of PAH exposure among subjects living in two separate regions from a steel mill显示文摘 | Mi-Sun Lee Ki-Do Eum Kyung-Duk Zoh Tak-Soo Kim Yun-Suk Pak Domyung Paek | 2007 | International Archives of Occupational and Environmental Health2007，，8： | 1 |
| 15 | In vivo protein transductinn: biologically active intact pep-1-superoxide dismutase fusion protein efficiently protects against ischemic insult 显示文摘 | Eum V S Kim DW Hwang IK | 2004 | Free Radie Biol Med2004，37，10： | 1 |
| 16 | Extended methods for identifying dominance and potential optimality in multi-criteria analysis with impreciseinformation 显示文摘 | Lee K S Park K S Eum Y S | 2001 | European Journal of Operational Research2001，134，： | 1 |
| 17 | Extended methods for identifying dominance and potential optimality in multicriteria analysis with imprecise information显示文摘 | Lee K S Park K S Eum Y S | 2001 | European Journal of Operational Research2001，134，3： | 1 |
| 18 | Differential inhibitory effects of two Raf-targeting drugs, sorafenib and PLX4720, on the growth of multi- drug-resistant ceils 显示文摘 | Eum KH Ahn SK Kang H | 2013 | Mol Cell Bioehem2013，372，12： | 1 |
| 19 | Establishing dominance and potential optimality in multi-criteria analysis with imprecise weight and value显示文摘 | Eum Y S Park K S Kim S H | | 0，，05： | 1 |
| 20 | Extended Methods for Identifying Dominance and Potential Optimality in Muhi-Criteria Analysis With Imprecise Information显示文摘 | Lee K S Park K S Eum Y S | 2001 | European Journal of Operational Research2001，134，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员