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| 1 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | 显示文摘 | Blagodatskikh I V Vasil'eva O V Ivanova E M | 2004 | Polymer2004，45，： | 1 |
| 4 | Liquidliquid extraction in the absence of usual organnic solvents : application of two-phase aqueous systems based on awatersoluble polymer 显示文摘 | Zvarova T I Shkinev V M Vorob'eva G A | 1984 | Mikrochimica Acta1984，，3： | 1 |
| 5 | Atom transfer radical polymerization of methyl acrylate from a multifunctional initiator at ambient temperature显示文摘 | ANNA C ROBERT V EVA M J | 2002 | Polymer2002，43，： | 1 |
| 6 | Synthesis and immunomodulating activity of new amino acid derivatives of glycyrrhizic acid and its methyl ester显示文摘 | Baltina L A Vasil' eva E V | 2004 | Bioorg Khim2004，30，2： | 1 |
| 7 | Effect of calcium dips and chitosan coatings on postharvest life of strawberries (Fragaria x ananassa) 显示文摘 | Pilaf H M Eva A Valeria D V | 2008 | Food Chemistry2008，，110： | 1 |
| 8 | Synthesis and tuberculostatic activity of aminoquinazoline derivatives显示文摘 | Murav'eva K M Arkhangel'skaya N V Shchukina M N | 1971 | Pharmaceutical Chemistry Journal1971，5，6： | 1 |
| 9 | The combined therapy with valdoxan and amitriptyline of treatment resistant somatized depression 显示文摘 | Sobennikov V Prokop' eva M | 2013 | Zhur- nal Nevrol Psikhiatr Im S S Korsakova2013，113，2： | 1 |
| 10 | Changes in contrast thresholds with mean Luminance for chromatic and luminance gratings: A re-examin- ation of the transition fi'om the DeVries-Rose to Weber regions 显示文摘 | Eva M V Juan L N Jose A G | 2004 | Colour research and application2004，29，3： | 1 |
| 11 | Crystal structure of a GCN5-related N-acety ltransferase:serratia marcescens aminoglycoside 3-N-acetyltransferase显示文摘 | Eva w Alex V Yasutaka M | 1998 | Cell1998，，94： | 1 |
| 12 | Liquid-Liquid Extraction in the Absence of Usual Organic Solvents:Application of Two-Phase Aqueous Systems Based on a Water-Soluble Polymer显示文摘 | Zvarova T I Shkinev V M Vorob' eva G A | 1984 | Mikrochimica Acta1984，，3： | 1 |
| 13 | Separation of amino acids mixtures containing tyrosine in electromem brahe system 显示文摘 | Bukhovets A E Savel' eva A M Eliseeva T V | 2009 | Desalination2009，241，： | 1 |
| 14 | Two-stage bacterial-chemical oxidation of refractory gold-bearing sulfidic concentrates显示文摘 | FOMCHENKO N V MURAVYOV M I KONDRAT'EVA T F | 2010 | HydrometaUurgy2010，101，1： | 1 |
| 15 | Teaching from the clinical reasoning literature:combined reasoning strategies help novice diagnosticians overcome misleading information显示文摘 | Eva K W Hatala R M Lebianc V R | 2007 | Meal Edue2007，41，12： | 1 |
| 16 | Evaluating the industrial potential of Diodiesel from a microalgae heterotrophic culture: scale-up and economics显示文摘 | Antonio T Eva M M d V Miguel A G | 2012 | Biochemical Engineering Journal2012，63，： | 1 |
| 17 | Relationship between the Secondary Structure and the Regulatory Activity of the Leader Region of the Riboflavin Biosynthesis Operon in Bacillus subtilis 显示文摘 | Mironov A S Karelov D V Solov'eva I M | 2008 | Genetika2008，44，4： | 1 |
| 18 | Isoquercitrin - A component of the leaves of Fraxinus mandschurica 显示文摘 | Artem'eva M V Nikonov G K Nezhinskaya G A | 1975 | Chemistry of Natural Compounds1975，9，3： | 1 |
| 19 | Structures and reactions of monomeric and dimeric lithium diazapentadienyl complexes with electrophiles: Synthesis of a-C, C'-dialkyl-β-diimines, and dissolution-reversible synthesis of an a-alkoxylithium-β-diimine显示文摘 | Carey D T Cope-Eatough E K Eva V M | 2003 | Dalton Trans2003，，： | 1 |
| 20 | Highly effective Mg2Si1-xSnx thermoelectrics显示文摘 | ZAITSEV V K FEDOROV M I GUR/EVA E A | 2006 | Physical Review B2006，74，04： | 1 |
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