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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Some 7-Substituted 4-aminoquinoline derivatives显示文摘 | Alexander R S Henry F H | 1946 | J Am Chem Soc1946，18，： | 2 |
| 3 | Risk factors associated with major cerebrovascular complications after intracranial stenting显示文摘 | F Nahab M J. Lynn S E. Kasner M J. Alexander R Klucznik O O. Zaidat J Chaloupka H Lutsep S Barnwell M Mawad B Lane M I. Chimowitz | 2009 | Neurology2009，，23： | 2 |
| 4 | Selectivegrowth of SWNTs on partially reduced monometalliccobait catalyst 显示文摘 | Maoshuai H Alexander I C Pavel V F | 2011 | Chem Commun2011，47，： | 1 |
| 5 | How soon after quitting smoking does risk of heart attack decline显示文摘 | Dobson A J Alexander H M Heller R F | 1991 | J Clin Epidemiol1991，44，： | 1 |
| 6 | Mycotoxin de- toxication of animal feed by different adsorbents 显示文摘 | Alexander H Stefan F Othmar K | 2001 | Toxicology Letters2001，122，2： | 1 |
| 7 | How soon after quitting smoking does risk of heart attack decline? 显示文摘 | DOBSON A J ALEXANDER H M HELLER R F | 1991 | J Clin Epidemiol1991，44，1： | 1 |
| 8 | Image spectrometry for earth remote sensing 显示文摘 | Goetz Alexander F H Vane G Solomon J E | 1985 | Science1985，228，4704： | 1 |
| 9 | Use of hyperspectral images in the identification and mapping of expansive clay soils and the role of spatial resolution显示文摘 | SABINE CHABRILLAT ALEXANDER F H GOETZ LISA KROSLEY | 2002 | Remote Sensing of Environment2002，82，： | 1 |
| 10 | Terrestrial imaging spectrometry: current status, future trends显示文摘 | Vane G-regg Goetz Alexander F H | 1993 | Remote Sens Environ1993，44，23： | 1 |
| 11 | PASS for retrofitting,extending and constructing new high-voltage substations显示文摘 | Peter H Dieter F Alexander K | 1998 | ABB Review1998，2，： | 1 |
| 12 | Interstellar chemistry recorded in organic matter from primitive meteorites显示文摘 | Busemann H Young A F Alexander C M O D | 2006 | Science2006，312，： | 1 |
| 13 | Characterization ot cirrus clouds from multi-pass AVIRIS data显示文摘 | F H Alexander Oaetz | 1994 | Geoscience and Remote Sensing Symposium1994，，1： | 1 |
| 14 | The first isolation of the avian PMV-1 virus responsible for the current panzootic in pigeons ? 显示文摘 | Kaleta E F Alexander D J Russell P H | 1985 | Avian Pathol1985，14，4： | 1 |
| 15 | A randomized controlled trial of stress reduction in African Americans treated for hypertension for over one year 显示文摘 | Schneider R H Alexander C N Staggers F | 2005 | Am J Hypertens2005，18，1： | 1 |
| 16 | Effects of hyperthermia and tumour necrosis factor on inflammatory cytokine secretion and procoagulant activity in endothelial cells显示文摘 | GNANT M F TURNER E M ALEXANDER H R | 2000 | Cytokine2000，12，4： | 1 |
| 17 | The preparation of bz-dichloro-4-aminoquinoline derivatives显示文摘 | Alexander R S Henry F H | 1946 | J Amer Chem Soc1946，68，： | 1 |
| 18 | Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on k-ras mutation analysis 显示文摘 | Alexander Sefre F Salvesen H B Ryan A | 2003 | Gynecol Oncol2003，91，1： | 1 |
| 19 | History and evolution of antibiotic resistance in coagulase-negative staphylococci : susceptibili- ty profiles of new anti-staphylococcal agents显示文摘 | JOSEPH F J ALEXANDER M H RALPH H J | 2007 | Ther Clin Risk Man- ag2007，，36： | 1 |
| 20 | Sodium nitrate particles: physical and chemical properties during hydration and dehydration, and implications for aged sea salt aerosols显示文摘 | Rachel H Alexander L Barbara F | 2004 | Aerosol Science2004，，： | 1 |
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