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| 1 | Trends in incidence and management of cancer of the ampulla of Vater显示文摘AIM:To provide trends in incidence,management and survival of cancer of the ampulla of Vater in a welldefined French population.METHODS:Data were obtained from the populationbased digestive cancer registry of Burgundy over a34-year period.Age-standardized incidence rates were computed using the world standard population.Average annual variations in incidence rates were estimated using a poisson regression.A univariate and multivariate relative survival analysis was performed.RESULTS:Age-standardized incidence rates were0.46 and 0.30 per 100000 inhabitants for men and women,respectively.Incidence rate increased from0.26(1976-1984)to 0.58(2003-2009)for men and remained stable for women.Resection for cure was performed in 48.3%of cases.This proportion was stable over the study period.Among cases with curative resection,pancreatico-duodenectomy was performed in94.0%of cases and ampullectomy in 6.0%of cases.A total of 50.8%of cancers of the ampulla of Vater were diagnosed at an advanced stage.Their proportion remained stable throughout the study period.The overall1-and 5-year relative survival rates were 60.2%and27.7%,respectively.Relative survival did not vary over time.Treatment and stage at diagnosis were the most important determinants of survival.The 5-year relative survival rate was 41.5%after resection for cure,9.5%after palliative surgery and 6.7%after symptomatic treatment.In multivariate analysis,only stage at diagnosis significantly influenced the risk of death.CONCLUSION:Cancer of the ampulla of Vater is still uncommon,but its incidence increased for men in Burgundy.Diagnosis is often made at an advanced stage,dramatically worsening the prognosis. | Florian Rostain Samia Hamza Antoine Drouillard Jean Faivre Anne-Marie Bouvier C?me Lepage | 2014 | World Journal of Gastroenterology2014，20，29： | 5 |
| 2 | Epidemiology and Management of Liver Metastases From Colorectal Cancer显示文摘 | Sylvain Manfredi C?me Lepage Cyril Hatem Olivier Coatmeur Jean Faivre Anne-Marie Bouvier | 2006 | Annals of Surgery2006，，2： | 2 |
| 3 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 4 | Safety,pharmacokinetic,and antitumor activity of SU11248,a novel oral multitarget tyrosine kinase inhibitor,in patients with cancer显示文摘 | Faivre S Delbaldo C Vera K | 2006 | J Clin Oncol2006，24，1： | 1 |
| 5 | A simple HPL C-UV method for the simultaneous quantification of gefitinib and erlotinib in human plasma 显示文摘 | FAIVRE L GOMO C MIR O | 2011 | J Chromatogr B Analyt Technol Biomed Life Sci2011，879，23： | 1 |
| 6 | Safety, pharmacokinetic, and antitumor activity of SUl1248, a novel oral multitarget tyrosine kinase inhibitor,in patients with cancer显示文摘 | FAIVRE S DELBALDO C VERA K | 2006 | J ClinOnco12006，24，1： | 1 |
| 7 | Combined con servative surgical and medical treatment of a uterocutane ous fistula显示文摘 | Thubert T Denoiseux C Faivre E | 2012 | J Minim Invasive Gynecol2012，19，2： | 1 |
| 8 | Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib显示文摘 | Maria Serova Armand Gramont Annemila? Tijeras-Raballand Célia Santos Maria Eugenia Riveiro Khemaies Slimane Sandrine Faivre Eric Raymond | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 1 |
| 9 | CONVERT : concurrent once - daily versus twice - daily radiotherapy - a new phase HI random- ized controlled trial for patients with limited - stage small cell lung cancer and good performance status 显示文摘 | Faivre - Finn C Falk S | 2009 | Lung Cancer2009，63，2： | 1 |
| 10 | A simple HPLC-UV method for the simultaneous quantification of gefitinib and erlotinib in human plasma显示文摘 | Faivre L Gomo C Mir O | 2011 | J Chromatogr B Analyt Technol Biomed Life Sci2011，879，23： | 1 |
| 11 | Case report:perioperative immediate hypersensitivity involves only allergy but also masttocytosis显示文摘 | Renauld V Goudet V Mouton Faivre C | | 0，，5： | 1 |
| 12 | End points for new agents ininduction chemotherapy for locally advanced head and neck cancers 显示文摘 | Monnerat C Faivre S Temam S | 2002 | Ann Oncol2002，13，7： | 1 |
| 13 | Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral muhitarget tyrosine kinase inhibitor, in patients with cancer 显示文摘 | Faivre S Delbaldo C Vera K | 2006 | J Clin Oncol2006，24，： | 1 |
| 14 | Evaluation and aaanagement of acute radiation dermatitis显示文摘 | Modesto A Faivre J C Granel-Brocard F | 2012 | Cancer Radiother2012，16，56： | 1 |
| 15 | Oxaliplatin - induced damage of cellular DNA 显示文摘 | Woynarowski J M Faivre S Herzig M C S | 2000 | Molecular pharmacology2000，58，5： | 1 |
| 16 | Phase Ⅰ-Ⅱ and pharmacokinetic study of gemcitabine combined with oxaliplatin in patient s with ad- vanced non-small-cell lung cancer and ovarian carcinoma 显示文摘 | Faivre S Le Chevalier T Monnerat C | 2002 | Ann Oncol2002，13，9： | 1 |
| 17 | Phase Ⅰ -Ⅱ and pharmacokinetic study of gemcitabine combined with oxaliplatin in patients with advanced non-small-cell lung cancer and ovarian carcinoma显示文摘 | Le Chevalier T Monnerat C | 2002 | Ann Oncol2002，13，9： | 1 |
| 18 | A simple I-Ir'LtS-UV memoo for the simultaneous quantification of gefitinib and erlotinib in human plasmas显示文摘 | Faivre L Gomo C Mir O | 2011 | Journal of Chromatography B2011，879，23： | 1 |
| 19 | Safety,pharmacokinetic,and antitumor activity of SU11248,a novel oral multitarget tyrosine kinase inhibitor,in patients with cancer显示文摘 | FAIVRE S DELBALDO C VERA K | 2006 | J Clin Oncol2006，24，1： | 1 |
| 20 | Molecular targetedtherapy of head and neck cancer : review and clinical de-velopment challenges显示文摘 | Le Toumeau C Faivre S Siu L L | 2007 | Eur J Cancer2007，43，17： | 1 |
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