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您的检索式：作者名="FANG ChuShu"
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| 1 | 一种设计的抗癌多肽调控p53的两种翻译后修饰显示文摘文章简介蛋白质的翻译后修饰可能对蛋白质的表达和功能产生影响,同时也是重要的药物靶标。现有的方法通常只调控单一类型的翻译后修饰。本研究报道了一种同时调控两种翻译后修饰的多肽。 | 梁纶熙 王焕彬 Hubing Shi Zhaoli Li Han Yao Zhigao Bu Ningning Song Chushu Li Dabin Xiang Yao Zhang Jilin Wang Ye Hu Qi Xu Yanlei Ma Zhongyi Cheng Yingchao Wang Shuliang Zhao Jin Qian Yingxuan Chen Jing-Yuan Fang 许杰 | 2019 | 科学新闻2019，0，2： | 0 |
| 2 | ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity显示文摘Gastric acidity-associated disorders such as peptic ulcer and reflux diseases are widespread,and the reported resistance and side effects of currently used medicines suggest an urgent requirement for alternative therapeutic approaches.Here we demonstrate a critical role of ASAP3 in regulating the microvilli structure of parietal cells in vivo,and reveal the feasibility of controlling gastric acidity by targeting ASAP3.Conditional knockout of ASAP3 in mice caused elongation and stacking of microvilli in parietal cells,and substantially decreased gastric acid secretion.These were associated with active assembly of F-actin caused by a higher level of GTP-bound Arf6 GTPase.Consistently,a small molecular compound QS11 inhibited ASAP3 function and significantly reduced gastric acidity in vivo.Of note,the expression of ASAP3 was positively correlated with gastric acid secretion in 90 human cases,and high expression of ASAP3 was associated with reflux disease and peptic ulcer.These results reveal for the first time that ASAP3 regulates the microvilli structures in parietal cells.Our data also suggest ASAP3 as a feasible and drugable therapeutic target for gastric acidity-associated diseases. | Jin Qian Yueyuan Li Han Yao Haiying Tian Huanbin Wang Luoyan Ai Yuanhong Xie Yujie Bao Lunxi Liang Ye Hu Yao Zhang Jilin Wang Chushu Li Jiayin Tang Yingxuan Chen Jie Xu Jing-Yuan Fang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 3 | Design and development of a lightweight cryogenic system for high temperature superconducting(HTS)filters subsystem显示文摘Since the discovery of high temperature superconducting(HTS)materials in the 1980 s,HTS filters and motors have developed rapidly[1,2].The extremely low insertion loss and frequency selectivity of the HTS filter make it possible to greatly improve the signal receiving sensitivity and suppress interference noise.Therefore,it has great potential in aerospace application,satellite communications,mobile base stations,deep space exploration,radar,and other fields[3,4]. | DUAN YanBo WANG Jue WANG Wei WU ShanShan QI HaoYing WANG ZeKun FANG ChuShu HUANG RongJin LI LaiFeng ZHOU Yuan | 2022 | Science China(Technological Sciences)2022，65，3： | 0 |
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