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| 1 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 2 | Energy Structure,Marginal Efficiency and Substitution Rate:An Empirical Study of China显示文摘 | HanZY FanY JiaoJL YanJS Wei Y M | 2007 | Energy2007，32，6： | 1 |
| 3 | n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes显示文摘 | DAVIDSON L A FANY Y | 2001 | Am J Physiol2001，280，： | 1 |
| 4 | Analysis on additive effects and additive-by-additive epistatlc effects of QTLs for yield traits in a recombinant inbred line population of rice 显示文摘 | Zhuang J Y FanY Y Rao Z M | 2002 | Theor Appl Genet2002，105，： | 1 |
| 5 | Preparation oftitania micro filtration membranes supported on porous Ti-A1 alloys显示文摘 | ZhouSY FanY Q He Y H etal | 2008 | J Membr Sci2008，325，2： | 1 |
| 6 | Hydrogen storage in single-walled carbon nanotubes at room temperature显示文摘 | Li U C Fany Y Liu M | 1999 | Science1999，286，： | 1 |
| 7 | Spectroscopic,docking and molecular dynamics simulation studies on the interaction of two Schiff base complexes with human serum albumin显示文摘 | Fani N Bordbar A K Ghayeb Y | 2013 | Journal of Luminescence2013，141，16： | 1 |
| 8 | DielectricandconGductionpropertiesofpolyimide/silicananoGhybridfilms显示文摘 | ZhangM Y ZengSJ FanY etal | 2008 | PolymerComposites2008，29，6： | 1 |
| 9 | Cus-tomer complaints and service policy in elec-tronic commerce 显示文摘 | FanY W Miao Y F Wu S C | 2013 | South African Journalof Business Management2013，44，3： | 1 |
| 10 | Dietary gamma linolenic acid enhances mouse macrophage derived prostaglandin Elwhich inhibits vascular smooth muscle cell proliferation显示文摘 | FanY Y Ramos K S Chapkin R S | | 0，，09： | 1 |
| 11 | Doping competition of anions during the eleetropolymerization of pyrrole in aqueous solutions 显示文摘 | LI Y F FANY F | 1996 | Synthetic Met1996，79，： | 1 |
| 12 | Fast and robust deblurring method with multi-frame images based on PSF estimation and total variation optimization显示文摘 | FANY H WEIX M QINS Y | 2013 | Optik2013，124，： | 1 |
| 13 | Structure-Property Relation in Poly ( p-phenylene terephthalamide )( PPTA ) Fibers显示文摘 | Rao Y Waddon A J Fanis R J | 2001 | Polymer2001，42，13： | 1 |
| 14 | Aggregation of Non Parametric Estimators for Volatility Matrix 显示文摘 | FANI Q FAN Y Y LV J H | 2007 | Journal of Financial Econometrics2007，5，3： | 1 |
| 15 | The Evolution of Structure and Properties in Poly (p-phenylene terephthalamide ) Fibers显示文摘 | Rao Y Waddon A J Fanis R J | 2001 | Polymer2001，42，13： | 1 |
| 16 | Dry mycelium of Penicillium chrysogenum induces expression of pathogenesis-related protein genes and resistance against wilt diseases in Bt transgenic cotton显示文摘 | Dong H Z FanY Q | 2006 | Biological Control2006，39，： | 1 |
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