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| 1 | High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells显示文摘AIM: To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS: The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverse transcription polymerase chain reaction (RT-PCR) after transient transfection of SW480 cancer cells. The miR-196a transcription profile in colorectal cancer samples, mucosa samples and diverse cancer cell lines was quantifi ed by RT-PCR. Transiently miR-196a-transfected colorectal cancer cells were used for diverse functional assays in vitro and for a xenograft lung metastasis model in vivo. RESULTS: HoxA7, HoxB8, HoxC8 and HoxD8 were restricted by miR-196a in a dose-dependent and gene-specific manner. High levels of miR-196a activated the AKT signaling pathway as indicated by increased phosphorylation of AKT. In addition, high levels of miR-196a promoted cancer cell detachment,migration, invasion and chemosensitivity towards platin derivatives but did not impact on proliferation or apoptosis. Furthermore, miR-196a increased the development of lung metastases in mice after tail vein injection. CONCLUSION: miR-196a exerts a pro-oncogenic influence in colorectal cancer. | Carl Christoph Schimanski Kirsten Frerichs Fareed Rahman Martin Berger Hauke Lang Peter R Galle Markus Moehler Ines Gockel | 2009 | World Journal of Gastroenterology2009，15，17： | 40 |
| 2 | Effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis显示文摘BACKGROUND The role of prophylactic clipping for the prevention of delayed polypectomy bleeding(DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp sizes.AIM To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection(EMR) of colorectal lesions ≥ 20 mm.METHODS We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I^2 were used to test for heterogeneity. Pooling was conducted using a random-effects model.RESULTS Thirteen studies with a total of 7794 polyps were identified, of which data was available on 1701 cases of EMR of lesions ≥ 20 mm. Prophylactic clipping was associated with a lower rate of DPB(1.4%) when compared to no clipping(5.2%)(pooled OR: 0.24, 95%CI: 0.12-0.50, P < 0.001) following EMR of lesions ≥ 20 mm.There was no significant heterogeneity among the studies(I^2 = 0%, P = 0.67).CONLUSION Prophylactic clipping may reduce DPB following EMR of large colorectal lesions.Future trials are needed to further identify risk factors and stratify high risk cases in order to implement a cost-effective preventive strategy. | Fares Ayoub Donevan R Westerveld Justin J Forde Christopher E Forsmark Peter V Draganov Dennis Yang | 2019 | World Journal of Gastroenterology2019，25，18： | 9 |
| 3 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 4 | Multilateral Productivity Comparisons When Some Outputs Are Undesirable: A Nonparametric Approach 显示文摘 | Fare R Grosskopf S Lovell C | 1989 | Review of Economics and Statistics1989，71，1： | 1 |
| 5 | Network DEA显示文摘 | Fare R Grosskopf S | 2000 | Socio - Economic Planning Sciences2000，，34： | 1 |
| 6 | Productivity growth, technical progress and efficiency challenges in industrialized countries 显示文摘 | Fare R Grosskopf S Norris M | 1997 | The American Economic Review1997，87，： | 1 |
| 7 | Productivity growth,technical progress,and efficiency change in industrialized countries显示文摘 | Fare R Grosskopf S Norris M Zhang Z | 1994 | American Economic Review1994，84，： | 1 |
| 8 | Modeling undesirable factors in efficiency evaluation: Comment 显示文摘 | Fare R Grosskopf S | 2004 | European Journal of Operational Research2004，157，： | 1 |
| 9 | Productivity growth,technical progress,and efficiency change in industrialized countries显示文摘 | Fare R Grosskopf S Norris M | 1994 | AmericanEconomic Review1994，84，1： | 1 |
| 10 | Productivity changes in Swedish Pharmacies 1980- 1989: A Non- parametric Malmquist approach 显示文摘 | Fare R Grosskop{ S Lindgren B Roos P | 1992 | Journal of Productivity Analysis1992，，3： | 1 |
| 11 | Productivity and Undesirable Outputs:A Directional Distance Funct ion Approach显示文摘 | Chung Y H Fare R Grosskopf S | | 0，，： | 1 |
| 12 | Productivity growth technical progress and efficiency change in industrialized countries显示文摘 | Fare R Grosskopf S Norris Metal | 1994 | American Economic Review1994，84，1： | 1 |
| 13 | Productivity growth, technical progress and efficiency change in industrialized countries 显示文摘 | Fare R Grosskopf S Norris M etc | 1994 | The American Economist Review1994，84，1： | 1 |
| 14 | Robotic single port suprapubic transvesical enucleation of the prostate(R-STEP):initial experience显示文摘 | Fareed K Zaytoun O M Autorino R | 2012 | BJU Int2012，110，5： | 1 |
| 15 | Environmental production fun- ctions and environmental directional distance functions显示文摘 | Fare R Grosskopf S Pasurkajr C | 2007 | Ener- gy2007，32，7： | 1 |
| 16 | Productivity growth,Technical progress and efficiency change in industrialized countries显示文摘 | Fare R Grosskopf S | 1994 | American Economic Revies1994，，84： | 1 |
| 17 | Characteristics of a Polluting Technology: Theory and Practice 显示文摘 | Fare R Grosskopf S Noh D W | 2005 | Journal of Econometrics2005，126，2： | 1 |
| 18 | Environmental production flmctions and environmentaldirectional distance functions 显示文摘 | Fare R Grosskopf S Pasurka Jr C A | 2007 | Energy2007，32，： | 1 |
| 19 | A nonparametric cost approach to scale efficiency显示文摘 | Fare R Grosskopf S | 1985 | Journal of Econometrics1985，87，： | 1 |
| 20 | Slacks and congestion: a comment 显示文摘 | FARE R GROSSKOPF S | 2000 | Socio-Economic Planning Sciences2000，34，： | 1 |
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