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| 1 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl_4-induced hepatocellular carcinoma in Wistar rats显示文摘Objective:To investigation the chemopreventive potential of Fumaria indica(F.indica) extract(FIE) on N-nitrosodiethylamine and CCl4-induced hepatocarcinogenesis in Wislar rats.Methods:The experimental animals were divided into six groups(n=6).Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine(NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl4(3 mL/kg/week) for 6 weeks,as the promoter of carcinogenic effect.After administration of the carcinogen,200 and 400 mg/kg of FIE were administered orally once a day throughout the study.At the end of 20 weeks,the body weight,liver weight and relative liver weight were measured.The percentage of nodule incidence and liver cancer markers such as aspartate transaminase(AST),alanine transaminase(ALT),alkaline phosphatase(ALP),γ-glutamyl transferase(γ-GT),total bilirubin level(TBL),α-feto protein(AFP) and carcinoembryonic antigen were estimated along with histopathological investigation in experimental groups of rats. Results:Obtained results demonstrated that the cotreatment with FIE significantly prevented the decrease of the body weight and also increased in relative liver weight caused by NDEA. The treatment with FIE significantly reduced the nodule incidence and nodule multiplicity in the rats after NDEA administration.The levels of liver cancer markers such as AST,ALT,ALP,γ-glutamyl transferase,TBL,AFP and carcinoembryonic antigen were substantially increased by NDEA treatment.However,FIE treatment significantly reduced the liver injury and restored the entire liver cancer markers.Histological observations of liver tissues too correlated with the biochemical observations.Conclusions:These finding powerfully supports that F.indica exert chemopreventive effect by suppressing the tumor burden and restoring the activities of hepatic cancer marker enzymes on NDEA and CCl4-induced hepatocarcinogenesis in Wistar rats. | Talib Hussain Hefazat H Siddiqui Sheeba Fareed M Vijayakumar Chandana V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 3 |
| 3 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 4 | Prevention of venous thromboembolism : international consensus statement 显示文摘 | Nicottish A Breddin H Fareed J | 2002 | J Vasc Bras2002，1，： | 1 |
| 5 | Productivity and Undesirable Outputs:A Directional Distance Funct ion Approach显示文摘 | Chung Y H Fare R Grosskopf S | | 0，，： | 1 |
| 6 | Effects of atmospheric ozone on microarray data quality显示文摘 | Fare TL Coffey EM Dai H | 2003 | Anal Chem2003，75，17： | 1 |
| 7 | Productivity and undesirable outputs: a directional distance function approach显示文摘 | Chung Y H Fare R Grosskopf S | 1997 | Jour- nal of Environmental Management1997，51，3： | 1 |
| 8 | Hydro gels o{ starch-g-(tert-butylacrylate) and starch-g- (n-bu tylacrylate) copolymers 显示文摘 | Fares M M El-faqeeh A S Ghanem H | 2010 | Journal of Thermal Analy sis and Calorimetry2010，99，2： | 1 |
| 9 | Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic显示文摘 | Balklava Z Pant S Fares H | | 0，，09： | 1 |
| 10 | Productivity and undesirable outputs: a directional distance function approach显示文摘 | Chung Y H Fare R Grosskopf S | 1997 | Journal of Environmental Management1997，51，3： | 1 |
| 11 | Productivity and undesirable outputs:a directional distance function approach显示文摘 | Chung Y H Fare R Grosskopf S | 1997 | Journal of Environmental Management1997，51，： | 1 |
| 12 | Productivity and undesirable outputs:A directional distance function approach显示文摘 | CHUNG Y H FARE R GROSSKOPF S | 1997 | Journal of Environmental Management1997，，51： | 1 |
| 13 | Single-port transvesical enucleation of the pros tate:a clinical report of 34 cases显示文摘 | Desai M M Fareed K Berger A K Astigueta J C Irwin B H Aron M | 2010 | BJU Int2010，10，51： | 1 |
| 14 | Productivity and undesirable outputs: a directional distance function approach 显示文摘 | CHUNG Y H FARE R GROSSKOPF S | 1997 | Journal of Environmental Management1997，51，3： | 1 |
| 15 | Productivity and undesirable outputs: A directional distance function approach 显示文摘 | Chung Y H Fare R Grosskopf S | 1997 | Journal of Environmental Management1997，51，： | 1 |
| 16 | Productivity and Undesirable Outputs: A Directional Distance Func- tion Approach显示文摘 | Chung Y H Fare R Grosskopf S | 1997 | Journal of Environmental Manage- ment1997，51，3： | 1 |
| 17 | Productivity and Undesirable Outputs:A Directional Distance Function Approach显示文摘 | Chung Y H Fare R Grosskopf S | | 0，，03： | 1 |
| 18 | Productivity and undesirable outputs:A directional distance function approach显示文摘 | Y H Chung R Fare S Grosskopf | 1997 | Journal of environmental management1997，，51： | 1 |
| 19 | Productivity and Unde-sirable Outputs:A Directional Distance Function Approach显示文摘 | Chung Y H Fare R Grosskopf S | 1997 | Journal of Environmental Management1997，51，3： | 1 |
| 20 | Efflcacy, predictabili- ty, and safety of wavefront-guided refractive laser treatment : meta- analysis 显示文摘 | Fares U Suleman H A1-Aqaba MA | 2011 | J Cataract Refract Surg2011，37，8： | 1 |
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