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| 1 | Liver immunology and its role in inflammation and homeostasis显示文摘当一个非免疫学的机关首先从事了新陈代谢的、滋养的存储和 detoxification 活动,人的肝通常被察觉。然而,我们现在知道健康的肝也是复杂免疫学的一个地点活动象非造血的房间人口一样由一个多样的有免疫力的房间全部剧目调停了。在疾病得非的肝,新陈代谢并且织物改变功能要求发炎的元素。在有到饮食、微生物引起的产品的常规暴露的联合,这发炎为过多的有免疫力的激活创造潜力。在这复杂微型环境,肝的免疫系统容忍无害的分子当同时对可能的传染代理人仍然保持警惕时,恶意的房间或纸巾损坏。在到由病原体或织物损坏的挑战的适当有免疫力的激活之上,解决发炎的机制是必要的维持肝动态平衡。清除 ‘ 的失败; dangerous’刺激或调整适当地激活的有免疫力的机制导致病理学的发炎和纤维变性,肝硬化和最终的肝失败的进步发展描绘的破坏织物动态平衡。肝的煽动性的机制因此在健康的成年的肝有角色的一个系列;他们是必要的维持织物和机关动态平衡并且 dysregulated,肝病理的关键司机与长期的感染, autoimmunity 和恶意被联系。在这评论,我们在正常的肝动态平衡探索发炎和煽动性的调停人的变化感觉并且求婚作为一条治疗学的途径肝特定的有免疫力的规定小径指向治疗肝疾病。 | Mark W Robinson Cathal Harmon Cliona O'Farrelly | 2016 | Cellular & Molecular Immunology2016，13，3： | 65 |
| 2 | Inflammatory processes in the liver: divergent roles in homeostasis and pathology显示文摘The hepatic immune system is designed to tolerate diverse harmless foreign moieties to maintain homeostasis in the healthy liver.Constant priming and regulation ensure that appropriate immune activation occurs when challenged by pathogens and tissue damage.Failure to accurately discriminate,regulate,or effectively resolve inflammation offsets this balance,jeopardizing overall tissue health resulting from an either overly tolerant or an overactive inflammatory response.Compelling scientific and clinical evidence links dysregulated hepatic immune and inflammatory responses upon sterile injury to several pathological conditions in the liver,particularly nonalcoholic steatohepatitis and ischemia-reperfusion injury.Murine and human studies have described interactions between diverse immune repertoires and nonhematopoietic cell populations in both physiological and pathological activities in the liver,although the molecular mechanisms driving these associations are not clearly understood.Here,we review the dynamic roles of inflammatory mediators in responses to sterile injury in the context of homeostasis and disease,the clinical implications of dysregulated hepatic immune activity and therapeutic developments to regulate liver-specific immunity. | Ola Ahmed Mark W.Robinson Cliona O’Farrelly | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 3 | The synthetic form of a novel chicken β-defensin identified in silico is predominantly active against intestinal pathogens显示文摘 | Rowan Higgs David J. Lynn Susan Gaines Jessica McMahon Joanna Tierney Tharappel James Andrew T. Lloyd Grace Mulcahy Cliona O’Farrelly | 2005 | Immunogenetics (-)2005，，1： | 3 |
| 4 | Therapeutic concentra- tions of valproate but not a mitriptyline increase neuropeptide Y(NPY) expression in the human SH - SY5Y neuroblastoma cell line 显示文摘 | Farrelly LA Savage NT O'Callaghan C | 2013 | Regul Pept2013，186，： | 1 |
| 5 | Phenctypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection显示文摘 | Golden -Mason L Castelblanco N O' Farrelly C | 2007 | J Virol2007，81，： | 1 |
| 6 | Cleavage of soil by tined implements显示文摘 | O'Callaghan J R Farrelly K M | 1964 | Journal of Agricultural Engineering Research1964，9，3： | 1 |
| 7 | The impact of work place smoking bans:results from a national survey 显示文摘 | Farrelly MC Evans WN Sfekas AE | 1999 | Tob Control1999，8，3： | 1 |
| 8 | The affect of chronic hepatitis C infection on dendritic cell function: a summary of the experimental evidence 显示文摘 | Ryan EJ O'Farrelly C | 2011 | J Viral Hepat2011，18，9： | 1 |
| 9 | Do all non-calcified echogenic renal lesions found on ultrasound need further evaluation with CT? 显示文摘 | Farrelly C Delaney H Mcdermott R | 2008 | Abdom Imaging2008，33，： | 1 |
| 10 | The quest for authenticity in consumption:consumers'purposive choice of authentic cues to shape experienced outcomes显示文摘 | Beverland M B Farrelly F J | 2010 | Journal of Consumer Research2010，36，5： | 1 |
| 11 | Low dose dual- source CT angiography of the thoracic aorta显示文摘 | Farrelly C Davarpanah A Keeling AN | 2011 | lnt J Cardiovasc Imaging2011，27，7： | 1 |
| 12 | Distinct subpopulations of γδ T cells are present in normal and tumor-bearing human liver显示文摘 | Tony Kenna Lucy Golden-Mason Suzanne Norris John E. Hegarty Cliona O'Farrelly Derek G. Doherty | 2004 | Clinical Immunology2004，，1： | 1 |
| 13 | Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC) 显示文摘 | Doherty R O' Farrelly C Meade KG | 2013 | Vet Immunol Immunopathol2013，154，34： | 1 |
| 14 | Effect of genome size and rrn gene copy number on PCR amplification of 16S rRNA genes from a mixture of bacteria species显示文摘 | Farrelly V Rainey F A Stackebrandt E | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 15 | Smoking and Thyroid-Associated Ophthalmopathy: A Novel Explanation of the Biological Link显示文摘 | T J. Cawood P Moriarty C O’Farrelly D O’Shea | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，1： | 1 |
| 16 | Canine gastrointestinal strornal tumors: immunohistochemical expression of CD34 and examination of prognostic indicators including proliferation markers Ki67 and AgNOR 显示文摘 | Gilleapie V Baer K Farrelly J | 2011 | Vet Pathol2011，48，1： | 1 |
| 17 | Innate and adaptive lymphoid cells in the human liver 显示文摘 | Doherty DG O'Farrelly C | 2000 | Immunol Rev2000，174，： | 1 |
| 18 | Microanatomy of the liver immune system 显示文摘 | Nemeth E Baird AW O' Farrelly C | 2009 | Semin Immunopathol2009，31，3： | 1 |
| 19 | Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes显示文摘 | Norris S O'Farrelly C | 1998 | Journal of Hepatology1998，28，： | 1 |
| 20 | The human liver contains multiple populations of NK cells, T cells, and CD3* CD56' natural T cells with distinct cytotoxic activities and Thl, Th2, and Th0 cytokine secretion patterns显示文摘 | Doherty DG O'Farrelly C | 1999 | Journal of Immunology1999，163，： | 1 |
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