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| 1 | Cloning and characterization of a mouse liver-specific gene mfrep-1,up-regulated in liver regeneration显示文摘Human fibrinogen-related protein-1/liver fibrinogen-related protein-1 (HFREP-1/LFIRE-1), a liver-specificprotein, is a member of fibrinogen superfamily that exerts various biological activities. However, the func-tion of HFREP-1/LFIRE-1 in liver remains unknown. Here we isolated its mouse ortholog gene-mousefibrinogen-related protein-1 (mfrep-1), which encoded 314 amino acids, exhibiting 80.4% similarity toHFREP-1/LFIRE-1. Northern blot analysis revealed that 1.2-kb mfrep-1 mRNA was detected selectivelyin mouse liver. To explore the function of MFREP-1, we examined the levels of mfrep-1 mRNA duringregeneration after 70% partial hepatectomy (PHx) in mice. mfrep-1 mRNA increased in the regeneratingliver and reached the first shoulder peak at 2-4 h after PHx. Cycloheximide pretreatment could suppress theinduction of mfrep-1, indicating the up-regulation of this gene need de novo protein synthesis. Its mRNAcontinued to elevate at 6 h thereafter and reached the second peak at 24 h. The enhanced expression ofmfrep-1 maintained high until 72 h and then declined slowly to the basal level. Immunohistochemistryassessment confirmed the up-regulated expression of MFREP-1 protein in parenchymal cells during liverregeneration. These data suggested that MFREP-1 might play an important role in liver regeneration andbe involved in the regulation of cell growth. | JUNYAN HAOYING FEIGU JINHE YuLILI HuIMINLIU YONGHUAXU | 2002 | Cell Research2002，12，5： | 5 |
| 2 | RESEARCH ON MODEL AND METHOD OF NETWORK-BASED COOPERATIVE COMMERCE CHAIN IN AUTOMOBOLE INDUSTRY显示文摘Based on the analysis on the development of the cooperative commerce in automobile industry, the systematic model of the cooperative commerce chain in automobile industry is illustrated,the flow of agent-based NCCC (network-based cooperative commerce chain) system is described, and the method and NCCC system in automobile industry are developed, and so the correctness and the feasibility of the theory and the method are confirmed. | Xiong LiChen ZichenZhang FeiGu XinjianInstitute of Modem AdvancedProduction Engineering,Zhejiang University,Hangzhou 310027, China | 2003 | Chinese Journal of Mechanical Engineering2003，16，4： | 0 |
| 3 | The Effect of Board Characteristics on a Firm's Strategic Change显示文摘 | Jian Zhou Yaodong Yu Mengting Zhai Feigu Zhou | 2014 | Frontiers of Business Research in China2014，8，3： | 0 |
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