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| 1 | Digital Simulation of Projective Non-Abelian Anyons with 68 Superconducting Qubits显示文摘Non-Abelian anyons are exotic quasiparticle excitations hosted by certain topological phases of matter.They break the fermion-boson dichotomy and obey non-Abelian braiding statistics:their interchanges yield unitary operations,rather than merely a phase factor,in a space spanned by topologically degenerate wavefunctions.They are the building blocks of topological quantum computing.However,experimental observation of non-Abelian anyons and their characterizing braiding statistics is notoriously challenging and has remained elusive hitherto,in spite of various theoretical proposals.Here,we report an experimental quantum digital simulation of projective non-Abelian anyons and their braiding statistics with up to 68 programmable superconducting qubits arranged on a two-dimensional lattice.By implementing the ground states of the toric-code model with twists through quantum circuits,we demonstrate that twists exchange electric and magnetic charges and behave as a particular type of non-Abelian anyons,i.e.,the Ising anyons.In particular,we show experimentally that these twists follow the fusion rules and non-Abelian braiding statistics of the Ising type,and can be explored to encode topological logical qubits.Furthermore,we demonstrate how to implement both single-and two-qubit logic gates through applying a sequence of elementary Pauli gates on the underlying physical qubits.Our results demonstrate a versatile quantum digital approach for simulating non-Abelian anyons,offering a new lens into the study of such peculiar quasiparticles. | Shibo Xu Zheng-Zhi Sun Ke Wang Liang Xiang Zehang Bao Zitian Zhu Fanhao Shen Zixuan Song Pengfei Zhang Wenhui Ren Xu Zhang Hang Dong Jinfeng Deng Jiachen Chen Yaozu Wu Ziqi Tan Yu Gao Feitong Jin Xuhao Zhu Chuanyu Zhang Ning Wang Yiren Zou Jiarun Zhong Aosai Zhang Weikang Li Wenjie Jiang Li-Wei Yu Yunyan Yao Zhen Wang Hekang Li Qiujiang Guo Chao Song H.Wang Dong-Ling Deng | 2023 | Chinese Physics Letters2023，40，6： | 0 |
| 2 | Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1显示文摘Introduction:Siva-1,as a pro-apoptotic protein,has been shown to induce extensive apoptosis in a number of different cell lines.In our previous study,we showed that overexpressed Siva-1 decreased the apoptosis of gastric cancer cells.So,we believe that it can also work as an anti-apoptotic protein.The present study aimed to determine the specific role of Siva-1 in anticancer drug resistance in gastric cancer in vivo and in vitro and preliminarily reveal the mechanism.Materials and Methods:A vincristine-resistant MKN-28/VCR gastric cancer cell line with stably downregulated Siva-1 was established.The effect of Siva-1 downregulation on chemotherapeutic drug resistance was assessed by measuring the IC50 and pump rate of doxorubicin.Proliferation,apoptosis of cells,and cell cycle were detected via colony formation assay andflow cytometry,respectively.Additionally,migration and invasion of cells was detected via wound healing and transwell assays.Moreover,we determined in vivo effects of LV-Siva-1-RNAi on tumor size,and apoptotic cells in tumor tissues were detected using TUNEL and hematoxylin and eosin staining.Results:Siva-1 downregulation reduced the pump rate of doxorubicin and enhanced the response to drug treatment.Siva-1 negatively regulated proliferation and promoted apoptosis of cells by potentiality G2-M phase arresting.Inhibition of Siva-1 expression in MKN-28/VCR cells significantly weakened wound healing ability and decreased invasion ability.Poly(C)-binding protein 1(PCBP1)was identified as a Siva-1-interacting protein in yeast two-hybrid screening.Semiquantitative RT-PCR and western blotting revealed that Siva-1 downregulation could inhibit expression of PCBP1,Akt,and NF-κB and eventually decrease the expression of MDR1 and MRP1.Conclusion:The current study demonstrated that the downregulation of Siva-1,which functions as a regulator of MDR1 and MRP1 gene expression in gastric cancer cells by inhibiting PCBP1/Akt/NF-κB signaling pathway expression,enhanced the sensitivity of gastric cancer cells to certain chemotherapies. | FANBIAO KONG KUN WU LIMING PANG YULIANG HUANG LEI LI JING XU FEITONG LI YAN QING ZHONGYU WANG XIURONG HUANG SHENG XU XIAOGANG ZHONG ZHOU ZHU XIAOTONG WANG JIANRONG YANG | 2022 | Oncology Research2022，30，6： | 0 |
| 3 | Contributions of Cs and Rb on Inhibiting Photo-induced Phase Segregation and En-hancement Optoelectronic Performances of MA_(1-y)XyPbI_(1.8)Br_(1.2)(X=Cs,Rb)Single Crystals显示文摘Introducing inorganic cation into hybrid organic-inorganic perovskites(HOIPs)has attracted great attention because of the enhancement stabilities without sacrificing their excellent optoelectronic properties.Here,we introduce Cs and Rb into MAPbI_(1.8)Br_(1.2)single crystals(SCs)to dig out the mixed cation effect on optoelectronic performances and phase stabilities.Both Rb and Cs can increase the lattice capacity,which is sufficient to relieve the lattice stress caused by photon energy,thus achieving the purpose of stabilizing the lattice structure and inhibiting migration of halide ions,compared with MAPbI_(1.8)Br_(1.2)SC.On the other hand,the smaller polarity of Rb and Cs reduces the electron-phonon coupling,thus significantly inhibiting the migration of halide ions.Meanwhile,through planar photo-detectors,MA_(0.9)Cs_(0.1)PbI_(1.8)Br_(1.2)-based device behaves much excellent optoelectronic performance(R=0.170 A/W,EQE=51.39%,D^(*)=4.42×10^(12)Jones,on/off ratio:~522). | Qing Yao Kaiyu Wang Jie Zhang Changqian Li Chenyu Shang Feitong Chen Qi Huang Qiqi Zhao Weiwei Zhang Xiaoyuan Zhan Jianxu Ding | 2022 | Chinese Journal of Structural Chemistry2022，41，5： | 0 |
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