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| 1 | A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria显示文摘To search for a new eco-friendly therapy for infectious disease caused by Escherichia coli,Staphylococcus aureus or Klebsiella oxytoca,we collected the vaginal swabs from healthy women,screened for Lactobacillus and found a strain repressing the growth of pathogenic bacteria.The new isolate was identified as L.gasseri by the colony morphology,Gram staining,biochemical reactions and confirmed by the 16 S rDNA sequencing.The HMV18 strain inhibited the growth of food-borne pathogens such as E.coli,S.aureus and K.oxytoca.The HMV18 strain was sensitive to penicillin,ampicillin,erythromycin,tetracycline and chloramphenicol.The HMV18 strain producedα-hemolysis.Pathological histology of the mice ileum showed that the mucosa,villi,lamina propria and crypt depth remained intact and there was no inflammation or hyperemia in the L.gasseri HMV18 gavaged group.L.gasseri HMV18 could not up-regulate inflammatory cytokines level of plasma.All the results suggested L.gasseri HMV18 is a candidate probiotic to be an additive for food preservation or drug to prevent food-borne diseases. | Xiang Gao Zixuan Wang Xiang Li Xiaoling Zhang Shengqiang Du Miaomiao Jia Dailun Hu Xianxian Jia Bin Cong Yan Zhang Chunling Ma Song Zhou Jun Zhang | 2022 | Food Science and Human Wellness2022，11，2： | 3 |
| 2 | Highly-efficient thermoelectric-driven light-emitting diodes based on colloidal quantum dots显示文摘Driven by sub-bandgap electric work and Peltier heat,thermoelectric-driven light-emitting diodes(TED-LEDs)not only offer much enhanced power-conversion-efficiency but also eliminate the waste heat generated during the operation of LEDs.However,costeffective and high-efficiency TED-LEDs are not readily accessible for the epitaxially grown III-V LEDs due to the high chip cost and efficiency droop at low-medium brightness(current densities).Here we show that electroluminescence of colloidal quantum dots(QDs)LEDs(QLEDs)circumvents the deficiencies faced by conventional LEDs.The optimal red-emitting device fabricated by cost-effective solution processing technics exhibits external-and internal-power-conversion-efficiency of 21.5%and 93.5%at 100 cd/m^(2),suited for high-efficiency solid-state lighting and high-resolution display.At this brightness,the electric driving voltage(V)of 1.89 V is lower than the photon voltage(Vp=hv/q=1.96 V,q being the elemental charge).With typical Vp=1.96 V,electroluminescence can be detected with the driving voltage as low as 1.0-1.2 V.Luminance of the thermoelectric-driven QLEDs(TED-QLEDs)remains ideally diffusion-dominated with the driving voltage lower than~1.5 V,and further improvement on charge transport is expected to extend the linear ideality to all practical driving voltages. | Xing Lin Xingliang Dai Zikang Ye Yufei Shu Zixuan Song Xiaogang Peng | 2022 | Nano Research2022，15，10： | 2 |
| 3 | Wearable and flexible electrochemical sensors for sweat analysis:a review显示文摘Flexible wearable sweat sensors allow continuous,real-time,noninvasive detection of sweat analytes,provide insight into human physiology at the molecular level,and have received significant attention for their promising applications in personalized health monitoring.Electrochemical sensors are the best choice for wearable sweat sensors due to their high performance,low cost,miniaturization,and wide applicability.Recent developments in soft microfluidics,multiplexed biosensing,energy harvesting devices,and materials have advanced the compatibility of wearable electrochemical sweat-sensing platforms.In this review,we summarize the potential of sweat for medical detection and methods for sweat stimulation and collection.This paper provides an overview of the components of wearable sweat sensors and recent developments in materials and power supply technologies and highlights some typical sensing platforms for different types of analytes.Finally,the paper ends with a discussion of the challenges and a view of the prospective development of this exciting field. | Fupeng Gao Chunxiu Liu Lichao Zhang Tiezhu Liu Zheng Wang Zixuan Song Haoyuan Cai Zhen Fang Jiamin Chen Junbo Wang Mengdi Han Jun Wang Kai Lin Ruoyong Wang Mingxiao Li Qian Mei Xibo Ma Shuli Liang Guangyang Gou Ning Xue | 2023 | Microsystems & Nanoengineering2023，9，1： | 2 |
| 4 | Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs显示文摘Fusobacterium nucleatum(F.nucleatum)is an early pathogenic colonizer in periodontitis,but the host response to infection with this pathogen remains unclear.In this study,we built an F.nucleatum infectious model with human periodontal ligament stem cells(PDLSCs)and showed that F.nucleatum could inhibit proliferation,and facilitate apoptosis,ferroptosis,and inflammatory cytokine production in a dose-dependent manner.The F.nucleatum adhesin Fad A acted as a proinflammatory virulence factor and increased the expression of interleukin(IL)-1β,IL-6 and IL-8.Further study showed that Fad A could bind with PEBP1 to activate the Raf1-MAPK and IKK-NF-κB signaling pathways.Time-course RNA-sequencing analyses showed the cascade of gene activation process in PDLSCs with increasing durations of F.nucleatum infection.NFκB1 and NFκB2 upregulated after 3 h of F.nucleatum-infection,and the inflammatory-related genes in the NF-κB signaling pathway were serially elevated with time.Using computational drug repositioning analysis,we predicted and validated that two potential drugs(piperlongumine and fisetin)could attenuate the negative effects of F.nucleatum-infection.Collectively,this study unveils the potential pathogenic mechanisms of F.nucleatum and the host inflammatory response at the early stage of F.nucleatum infection. | Yushang Wang Lihua Wang Tianyong Sun Song Shen Zixuan Li Xiaomei Ma Xiufeng Gu Xiumei Zhang Ai Peng Xin Xu Qiang Feng | 2023 | International Journal of Oral Science2023，15，1： | 1 |
| 5 | Conductive proteins-based extracellular electron transfer of electroactive microorganisms显示文摘Electroactive microorganisms(EAMs)could utilize extracellular electron transfer(EET)pathways to exchange electrons and energy with their external surroundings.Conductive cytochrome proteins and nanowires play crucial roles in controlling electron transfer rate from cytosol to extracellular electrode.Many previous studies elucidated how the c-type cytochrome proteins and conductive nanowires are synthesized,assembled,and engineered to manipulate the EET rate,and quantified the kinetic processes of electron generation and EET.Here,we firstly overview the electron transfer pathways of EAMs and quantify the kinetic parameters that dictating intracellular electron production and EET.Secondly,we systematically review the structure,conductivity mechanisms,and engineering strategies to manipulate conductive cytochromes and nanowire in EAMs.Lastly,we outlook potential directions for future research in cytochromes and conductive nanowires for enhanced electron transfer.This article reviews the quantitative kinetics of intracellular electron production and EET,and the contribution of engineered c-type cytochromes and conductive nanowire in enhancing the EET rate,which lay the foundation for enhancing electron transfer capacity of EAMs. | Junqi Zhang Zixuan You Dingyuan Liu Rui Tang Chao Zhao Yingxiu Cao Feng Li Hao Song | 2023 | Quantitative Biology2023，11，4： | 0 |
| 6 | 3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction显示文摘At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic implants.This study explored the combination of 3D printing and tissue engineering to precisely reconstruct the auricle.First,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle reconstruction.In vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage fragments.In vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle reconstruction.The results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in vitro.After three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in vivo.The autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction. | Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang | 2023 | Bio-Design and Manufacturing2023，6，4： | 0 |
| 7 | Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering显示文摘Indole alkaloids have attracted considerable attention from synthetic chemists and biochemists for their structural diversity and important biological activities.Compared with traditional organic synthesis methods,the strategy of using cytochrome P450s'extraordinary abilities to selectively activate carbon-hydrogen bonds to assist in the synthesis of various indole alkaloids has the characteristics of short synthetic route,mild conditions and high atomic economy.Here,we utilized P450 monooxygenases HinD and TleB to synthesize a novel 6/5/8 tricyclic product from(S)-N-((S)-1-(4-fluoro-1H-indol-3-yl)-3-hydroxypropan-2-yl)-2-mercapto-3-methylbutanamide through the substrate structure-directed strategy.TleB was more effective in catalyzing C–S coupling,and was used to synthesize a series of 6/5/8 tricyclic indololactam derivatives to provide drug candidates.Interestingly,the S–S coupling product was observed in HinD catalysis,which was a minor product in the wild-type TleB catalysis.With the help of protein engineering,we accurately regulated the catalytic flow and reversed the selectivity of TleB to obtain the S–S coupling product.At the same time,the reaction mechanism was reasonably speculated by means of site blocking and protein-substrate complex analysis. | Xinying Ge Yan Long Jun Wang Bo Gu Zixuan Yang Yinyin Feng Shuo Zheng Yingying Li Wupeng Yan Heng Song | 2023 | Science China Chemistry2023，66，11： | 0 |
| 8 | Data and Model Driven Task Offloading Strategy in the Dynamic Mobile Edge Computing System显示文摘Mobile Edge Computing(MEC)provides communication and computational capabilities for the industrial Internet,meeting the demands of latency-sensitive tasks.Nevertheless,traditional model-driven task offloading strategies face challenges in adapting to situations with unknown network communication status and computational capabilities.This limitation becomes notably significant in complex industrial networks of high-speed railway.Motivated by these considerations,a data and model-driven task offloading problem is proposed in this paper.A redundant communication network is designed to adapt to anomalous channel states when tasks are offloaded to edge servers.The link switching mechanism is executed by the train according to the attributes of the completed task.The task offloading optimization problem is formulated by introducing data-driven prediction of communication states into the traditional model.Furthermore,the optimal strategy is achieved by employing the informer-based prediction algorithm and the quantum particle swarm optimization method,which effectively tackle real-time optimization problems due to their low time complexity.The simulations illustrate that the data and model-driven task offloading strategy can predict the communication state in advance,thus reducing the cost of the system and improving its robustness. | DONG Hairong WU Wei SONG Haifeng LIU Zhen ZHANG Zixuan | 2024 | Journal of Systems Science & Complexity2024，37，1： | 0 |
| 9 | Enhancing train position perception through Al-driven multi-source information fusion显示文摘This paper addresses the challenge of accurately and timely determining the position of a train,with specific consideration given to the integration of the global navigation satellite system(GNSS)and inertial navigation system(INS).To overcome the increasing errors in the INS during interruptions in GNSS signals,as well as the uncertainty associated with process and measurement noise,a deep learning-based method for train positioning is proposed.This method combines convolutional neural networks(CNN),long short-term memory(LSTM),and the invariant extended Kalman filter(IEKF)to enhance the perception of train positions.It effectively handles GNSS signal interruptions and mitigates the impact of noise.Experimental evaluation and comparisons with existing approaches are provided to illustrate the effectiveness and robustness of the proposed method. | Haifeng Song Zheyu Sun Hongwei Wang Tianwei Qu Zixuan Zhang Hairong Dong | 2023 | Control Theory and Technology2023，21，3： | 0 |
| 10 | Boosting SN38-based oral chemotherapy to combine reductionbioactivated structured lipid-mimetic prodrug with ascorbic acid显示文摘The reduction-responsive disulfide bonds have been widely used as bioactive linkages to facilitate a rapid release of anticancer drugs into tumor cells.However,the activation can be hindered by the kinetics of the thiol-disulfide exchange reactions.Supplementing with an additional reductant is a promising strategy to further boost drug release.Herein,inspired by the specific absorption mechanism of triglyceride fat,structured lipid-mimetic oral prodrugs of 7-ethyl-10-hydroxycamptothecin(SN38)were designed to improve intestinal permeability and bypass the first-pass effect.SN38 prodrugs were prepared into lipid formulations that could self-emulsify into nano-sized particles after entering the gastrointestinal tract.Surprisingly,we found that the oral bioavailability of the prodrug lipid formulation could be up to 2.69-fold higher than that of the parent SN38,indicating an effective oral delivery.In addition,the reduction-responsive disulfide bond was used as a linker,and ascorbic acid(ASC)was coadministrated to further promote the efficient release of SN38 from the prodrug.ASC enhanced the oral antitumor effect of the reduction-responsive oral prodrug and exhibited good safety.In summary,the combination of a structured lipid-mimetic prodrug and ASC was firstly demonstrated to boost the oral chemotherapy effect of the difficult-for-oral chemotherapeutics. | Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Zixuan Wang Haotian Zhang Zhonggui He Chutong Tian Jin Sun | 2022 | Nano Research2022，15，10： | 0 |
| 11 | A Continuous Fault Ride-through Scheme for DFIGs Under Commutation Failures in LCC-HVDC Transmission Systems显示文摘Experimental and theoretical studies have confirmed that,relative to a one-shot voltage fault,a doubly-fed induction generator(DFIG)will suffer a greater transient impact during continuous voltage faults.This paper presents the design and application of an effective scheme for DFIGs when a commutation failure(CF)occurs in a line-commutated converter based high-voltage direct current(LCC-HVDC)transmission system.First,transient demagnetization control without filters is proposed to offset the electromotive force(EMF)induced by the natural flux and other low-frequency flux components.Then,a rotor-side integrated impedance circuit is designed to limit the rotor overcurrent to ensure that the rotor-side converter(RSC)is controllable.Furthermore,coordinated control of the demagnetization and segmented reactive currents is implemented in the RSC.Comparative studies have shown that the proposed scheme can limit rotor fault currents and effectively improve the continuous fault ride-through capability of DFIGs. | Zixuan Zheng Donghui Song Kaijian Du Xianyong Xiao Jie Ren Qi Xie | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 12 | Digital Simulation of Projective Non-Abelian Anyons with 68 Superconducting Qubits显示文摘Non-Abelian anyons are exotic quasiparticle excitations hosted by certain topological phases of matter.They break the fermion-boson dichotomy and obey non-Abelian braiding statistics:their interchanges yield unitary operations,rather than merely a phase factor,in a space spanned by topologically degenerate wavefunctions.They are the building blocks of topological quantum computing.However,experimental observation of non-Abelian anyons and their characterizing braiding statistics is notoriously challenging and has remained elusive hitherto,in spite of various theoretical proposals.Here,we report an experimental quantum digital simulation of projective non-Abelian anyons and their braiding statistics with up to 68 programmable superconducting qubits arranged on a two-dimensional lattice.By implementing the ground states of the toric-code model with twists through quantum circuits,we demonstrate that twists exchange electric and magnetic charges and behave as a particular type of non-Abelian anyons,i.e.,the Ising anyons.In particular,we show experimentally that these twists follow the fusion rules and non-Abelian braiding statistics of the Ising type,and can be explored to encode topological logical qubits.Furthermore,we demonstrate how to implement both single-and two-qubit logic gates through applying a sequence of elementary Pauli gates on the underlying physical qubits.Our results demonstrate a versatile quantum digital approach for simulating non-Abelian anyons,offering a new lens into the study of such peculiar quasiparticles. | Shibo Xu Zheng-Zhi Sun Ke Wang Liang Xiang Zehang Bao Zitian Zhu Fanhao Shen Zixuan Song Pengfei Zhang Wenhui Ren Xu Zhang Hang Dong Jinfeng Deng Jiachen Chen Yaozu Wu Ziqi Tan Yu Gao Feitong Jin Xuhao Zhu Chuanyu Zhang Ning Wang Yiren Zou Jiarun Zhong Aosai Zhang Weikang Li Wenjie Jiang Li-Wei Yu Yunyan Yao Zhen Wang Hekang Li Qiujiang Guo Chao Song H.Wang Dong-Ling Deng | 2023 | Chinese Physics Letters2023，40，6： | 0 |
| 13 | Erratum to:Boosting SN38-based oral chemotherapy to combine reduction-bioactivated structured lipid-mimetic prodrug with ascorbic acid显示文摘Erratum to Nano Research 2022,15(10):9092-9104 http://gffzzd3cc09b8251d45dfs5b9f6k9nv56x6u96.ffgz.tsg.suse.edu.cn/10.1007/s12274-022-4544-7 Figure 9 was unfortunately mistakenly typeset.This error did not affect any of the conclusions from the published paper. | Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Haotian Zhang Zhonggui He Zixuan Wang Chutong Tian Jin Sun | 2023 | Nano Research2023，16，4： | 0 |
| 14 | A model predictive control strategy with switching cost functions for cooperative operation of trains显示文摘The cooperative control of trains is proposed as an innovative method for further improving operation efficiency.Model predictive control(MPC)has been widely discussed for multiple trains because it can handle the challenges posed by the cooperative control problem,such as complex constraints.In real situations,multiple objectives,such as comfort and safety,must be considered when controlling multiple trains with MPC,and the total objective may change during operation,affecting control performance.In this paper,a distributed structure based on switching cost function model predictive control(ScMPC)for multiple trains in a switching situation is given,where the cost functions of the train control problem change with the variable demand of cooperative operation.Furthermore,the feasibility of the proposed method and stability of the closed-loop system are proved to guarantee the stable operation of the controlled trains.Finally,the control method’s effectiveness is verified.Three kinds of cost functions are given,and their control performance is compared to show the effect of different weights and the advantage of ScMPC. | Zixuan ZHANG Haifeng SONG Hongwei WANG Ling LIU Hairong DONG | 2023 | Science China(Information Sciences)2023，66，7： | 0 |
| 15 | Degradation properties of fulvic acid and its microbially driven mechanism from a partial nitritation bioreactor through multi-spectral and bioinformatic analysis显示文摘This study employed multispectral techniques to evaluate fulvic acid(FA)compositional characteristic and elucidate its biodegradation mechanisms during partial nitritation(PN)process.Results showed that FA removal efficiency(FRE)decreased from 90.22 to 23.11%when FA concentrations in the reactor were increased from 0 to 162.30 mg/L,and that molecular size,degree of aromatization and humification of the effluent FA macromolecules all increased after treatment.Microbial population analysis indicated that the proliferation of the Comamonas,OLB12 and Thauera exhibit high FA utilization capacity in lower concentrations(<50.59 mg/L),promoting the degradation and removal of macromolecular FA.In addition,the sustained increase in external FA may decrease the abundance of above functional microorganisms,resulting in a rapid drop in FRE.Furthermore,from the genetic perspective,the elevated FA levels restricted carbohydrate(ko00620,ko00010 and ko00020)and nitrogen(HAO,AMO,NIR and NOR)metabolism-related pathways,thereby impeding FA removal and total nitrogen loss associated with N_(2)O emissions. | Quanhao Dou Li Zhang Tingjun Dong Zixuan Song Xuepeng Fan Yongzhen Peng Xiayan Wang Jiachun Yang | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 16 | Bifunctional Two-Dimensional Nanocomposite with Electromagnetic Wave Absorption and Anti-bacterial Performance显示文摘In current electronic information era,the complex application circumstance of 5G devices pursues the exploration of multi-functional electromagnetic wave(EMW)absorbent materials and it has become the crucial focus in industrial development.A two-dimensional(2D)graphite nanosheet decorated by nickel nanocapsules(2D graphite/Ni@C nanocomposite)was fabricated to possess the EMW absorption and the Escherichia coli(E.coli)anti-bacterial performance simultaneously.By adjusting the filling ratio and injecting nitrogen doping,the value of minimum reflection loss is−36.08 dB and the effective absorption bandwidth reaches to 5.12 GHz(from 11.4 to 16.52 GHz)with the mass ratio of 30 wt%and the absorber thickness of 2 mm.This 2D nanocomposite simultaneously gets an excellent anti-bacterial function expressing an E.coli anti-bacterial rate of 92%during 24 h which is significantly correlated to the interaction between the nanostructure of the 2D nanographite and the nickel ion released from Ni@C nanocapsules.This work provides a new approach to develop a promising 2D anti-bacterial EMW absorber. | Jiacheng Shen Xinrui Zhang Chunguang Yang Zixuan Lei Shuaizhen Li Lin Ma Dianyu Geng Song Ma Wei Liu Zhidong Zhang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，9： | 0 |
| 17 | Tuning microstructures of TC4 ELI to improve explosion resistance显示文摘A reasonable heat treatment process for TC4 ELI titanium alloy is crucial to tune microstructures to improve its explosion resistance.However,there is limited investigation on tuning microstructures of TC4 ELI to improve explosion resistance.Moreover,the current challenge is quantifying microstructural changes'effects on explosion resistance and incorporating microstructural changes into finite element models.This work aims to tune microstructures to improve explosion resistance and elucidate their anti-explosion mechanism,and find a suitable method to incorporate microstructural changes into finite element models.In this work,we systematically study the deformation and failure characteristics of TC4 ELI plates with varying microstructures using an air explosion test and LS-DYNA finite element modeling.The Johnson-Cook(JC)constitutive parameters are used to quantify the effects of microstructural changes on explosion resistance and incorporate microstructural changes into finite element models.Because of the heat treatment,one plate has equiaxed microstructure and the other has bimodal microstructure.The convex of the plate after the explosion has a quadratic relationship with the charge mass,and the simulation results demonstrate high reliability,with the error less than 17.5%.Therefore,it is feasible to obtain corresponding JC constitutive parameters based on the differences in microstructures and mechanical properties and characterize the effects of microstructural changes on explosion resistance.The bimodal target exhibits excellent deformation resistance.The response of bimodal microstructure to the shock wave may be more intense under explosive loading.The well-coordinated structure of the bimodal target enhances its resistance to deformation. | Changle Zhang Yangwei Wang Lin Wang Zixuan Ning Guoju Li Dongping Chen Zhi-Wei Yan Yuchen Song Xucai Wang | 2024 | Defence Technology(防务技术)2024，33，3： | 0 |
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