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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 3 | Factors affecting phosphate adsorption equilibria in lake sediments显示文摘 | Ku W C Digiano F A Feng T H | 1978 | Water Res1978，12，： | 2 |
| 4 | Selective formation of isobutane and isobutene from synthesis gas over zirconia catalysts prepared by a modified Sol Gel method显示文摘 | Feng Z T postula W S Erkey C | 1994 | Journal of catalysis1994，148，1： | 1 |
| 5 | Catchment-scale advection and dispersion as a mechanism for fractal scaling in stream tracer concentrations显示文摘 | Kirchner J W Feng X H Neal C | 2001 | Journal of hydrology2001，254，： | 1 |
| 6 | The structural and magnetic properties of Mn2 xFexNiGa Heusler alloys显示文摘 | LUO H Z MENG F B FENG Z Q LI Y X ZHU W WU G H ZHU X X JIANG C B XU H B | 2010 | J Appl Phys2010，107，01： | 1 |
| 7 | β-Adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCδ/p38 MAPK signalling in neonatal mouse cardiac fibroblasts显示文摘 | Chen C Du J Feng W | 2012 | Br J Pharmacol2012，166，2： | 1 |
| 8 | 查看详情显示文摘 | Liao Y Wang Y Q Feng X X Wang W C Xu F J Zhang L Q | | 0，，： | 1 |
| 9 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 10 | Perfusion culture of the diatom Nitzschia laevis for uhra-high yield of eicosapentaenoic acid显示文摘 | ZHIYOU W FENG C | 2002 | Process Biochemistry2002，38，4： | 1 |
| 11 | Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector显示文摘 | Feng M Jackson W H Jr Goldman C K | 1997 | Nat Biotechnol1997，15，： | 1 |
| 12 | Quantum spin Hall effect in si- licene and two- dimensional germanium 显示文摘 | Liu C C Feng W ~ao Y | 2011 | Phys Rev Lett2011，107，07： | 1 |
| 13 | Luminescence of nanosized ZnO/polyaniline films prepared by self- assembly 显示文摘 | Zhang J Y Feng H B Hao W C | 2006 | Ceramics international2006，33，5： | 1 |
| 14 | Thermodynamic and kinetic investigations on the reaction of O(3P) with HNO显示文摘 | Du B N Zhang W C Feng C J | 2004 | Journal of Molecular Structure (Theochem)2004，712，： | 1 |
| 15 | Power system operation risk assessment using credibility theory显示文摘 | Feng Y Q Wu W C Zhang B | 2008 | IEEE Transactions on Power Systems2008，23，3： | 1 |
| 16 | EEG default mode network in the human brain:spectral regional field powers显示文摘 | Chen A C Feng W Zhao H | | 0，，02： | 1 |
| 17 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 18 | Transferrin-conjugated nanoparticles of poly ( lactide ) -D-alpha-tocopheryl polyethylene glycol succlnate diblock copolymer for targeted drug delivery across the blood- brain barrier 显示文摘 | GAN C W FENG S S | 2010 | Biomaterials2010，31，30： | 1 |
| 19 | Synthesis of nano-scale silicon wires by exciter laser ablation at high temperature 显示文摘 | Yu D P Lee C S Bello I Sun X S Tang Y H Zhou G W Bai Z G Zhang Z Feng S Q | 1998 | Solid State Communication1998，105，6： | 1 |
| 20 | Fabrication of heteropolyoxomet alate-based photochromic inorganic-organic nanocomposites显示文摘 | Zhang T R Feng W Bao C Y | 2001 | J Mater Res2001，16，： | 1 |
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