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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Use offibrolytic enzymes to improve the nutritive value of ruminant diets A biochemical and in vitro runaen degradation assessment显示文摘 | Dario C Fergus L Mould M et (d | 2003 | Animal Feed Science and Technology2003，107，： | 1 |
| 3 | Assignment of the human gene for the al subunit of the skeletal muscle DHP-sensitivc Ca^2+ channel (CANAL1A3) to chromosome 1q31-q32 显示文摘 | RONALD G FERGUS C KIRK H | 1993 | Genomics1993，15，1： | 1 |
| 4 | Effect of light interLsity on sporulation of Botryosphaeria ribis 显示文摘 | Smith D H Fergus C D | 1971 | Mycopathologia1971，45，34： | 1 |
| 5 | The electrolytic properties of LaYO3 and LaAlO3 doped with alkalineearth oxides显示文摘 | Alcock C B Fergus J W Wang L | 1992 | Solid State Ionics1992，51，： | 1 |
| 6 | Is a STAS-based tool valid to triage patients at a specialist palliative care inpa- tient unit? 显示文摘 | Fergus C J Nicol J S Russell P B | 2008 | Int J Palliat Nuts2008，14，1： | 1 |
| 7 | Bilingualism: Consequences for mind and brain显示文摘 | Ellen B Fergus I M C Gigi L | 2012 | Trends in Cognitive Sciences2012，，4： | 1 |
| 8 | The electrolytic properties of LaYO3 and LaAlO3 doped with alkaline-earth oxides显示文摘 | ALCOCK C B FERGUS J W WANG L | 1992 | Solid State Ionics1992，51，34： | 1 |
| 9 | Levels of processing:A Framework for Memory Research显示文摘 | FERGUS C LOCKHART R S | 1972 | Journal of Verbal Leaning and Verbal Behavior1972，，11： | 1 |
| 10 | Multiscalelandscape and wetland drivers of lake total phosphorus and watercolor 显示文摘 | Fergus C E Soranno P A Cheruvelil K S | 2011 | Limnology and Oceanography2011，56，6： | 1 |
| 11 | A lpha-2 and imidazoline recepter agonists显示文摘 | Khan Z P Fergu son C N Jones R M | 1999 | Anaesthesia1999，54，2： | 1 |
| 12 | Effect of light intensity on sporulation of Botryosphaeria ribis 显示文摘 | Smith D H Fergus C D | 1971 | Mycopathologia1971，45，34： | 1 |
| 13 | Use offihrolytic enzymes to improve the nutritive value of ruminant diets A biochemical and in vitro rumen degradation assessment显示文摘 | Dario C Fergus L Mould M et a/ | 2003 | Animal Feed Science and Technology2003，107，： | 1 |
| 14 | Thermophilic and thermotolerant molds and amino- mycetes of mushroom compost during peak-heating显示文摘 | Fergus C L | 1964 | Myeolo- gia1964，56，： | 1 |
| 15 | Light effect on fruiting of Physarum gyrosum显示文摘 | FERGUS C L | 1963 | Mycologia1963，55，： | 1 |
| 16 | The effects of nutrients and temperature on germination and viability of the ascospores of Chaetomium rectopilium显示文摘 | Fergus C L Christine J D | 1975 | Mycologia1975，67，： | 1 |
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