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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 3 | Development of high performance multifilamentary Nb-Ti-Ta superconductor for LHC insertion quadrupoles 显示文摘 | Lee P J Fischer C M Larbalestier D C | 1999 | IEEE Trans Applied Superconductivity1999，9，2： | 1 |
| 4 | Biodegradable magnesium-hydroxyapatite metal matrix composites显示文摘 | WITTE F FEYERABEND F MAIER P FISCHER J STORMER M BLAWERT C DIETZEL W HORT N | 2007 | Biomaterials2007，28，： | 1 |
| 5 | Parturition at term:parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment显示文摘 | Winkler M Fischer D C Ruck P | 1999 | Hum Reprod1999，14，： | 1 |
| 6 | Organ distribution of Schmallenberg virus RNA in malformed newborns显示文摘 | BILK S SCHULZE C FISCHER M | 2013 | Vet Microbiol2013，159，12： | 1 |
| 7 | Knowledge interactions between universities and industry in Austria:sectoral patterns and determinants显示文摘 | Schartinger D Rammer C Fischer M M | | 0，，03： | 1 |
| 8 | Impaired behaviour,learning and memory,in adult mice neonatally exposed to hexabromocy-clododecane(HBCD)显示文摘 | ERIKSSON P FISCHER C WALLIN M | 2006 | Environmental Toxicology andPharmacology2006，21，3： | 1 |
| 9 | A Sharper View of Impact Craters from Clementine Data显示文摘 | Pieters c M Staid M I Fischer E M | 1994 | Science1994，266，： | 1 |
| 10 | Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IκB kinase signalsome activation and IκB proteolysis显示文摘 | Fischer C Page S Weber M | | 0，，： | 1 |
| 11 | Selected pro-inflamm- atory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis显示文摘 | Fischer C Drillich M Odau S | 2010 | Reprod Fertil Dev2010，22，5： | 1 |
| 12 | micro-RNA miR-27b impairs human adipocyte differentiation and targets PPARgamma显示文摘 | Karbiener M Fischer C Nowitsch S | | 0，，02： | 1 |
| 13 | Lcysteine on Ag (111):A combined STM and X-ray spectroscopy study of anchorage and deprotonation显示文摘 | Fischer S Papageorgiou A C Marschall M | | 0，，38： | 1 |
| 14 | Galectin-1 interacts with the alpha 5 beta 1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27显示文摘 | Fischer C Sanchez-Ruderisch H Welzel M | 2005 | J Biol Chem2005，280，37： | 1 |
| 15 | Anti-PIGF inhibits growth of VEGF (R)-inhibitor-resistant tumors without affecting healthy vessels显示文摘 | Fischer C Jonckx B Mazzone M | 2007 | Cell2007，131，3： | 1 |
| 16 | RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activationsignals and HIV-1 enhancement显示文摘 | ROSCIC-MRKIC B FISCHER M LEEMANN C | 2003 | Blood2003，102，4： | 1 |
| 17 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
| 18 | Large eddy simulations of mixed layer instabilities and sampling strategies显示文摘 | OZGOKMEN T M POJE A C FISCHER P F | 2011 | Ocean Model2011，39，3： | 1 |
| 19 | RAS strategy for IBM S/390 G5 and G6 显示文摘 | M Mueller L C Alves W Fischer | 1999 | IBM Journal of Research and Development1999，43，56： | 1 |
| 20 | The hand-foot syndrome-a frequent secondary manifestaiton in antineoplastic chemotherapy 显示文摘 | Janusch M Fischer M Marsch W C H | 2006 | Eur J I)ermatol2006，16，5： | 1 |
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