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| 1 | 2016年国际抗癫痫联盟癫痫发作分类的更新及介绍显示文摘国际抗癫痫联盟(ILAE)提出了癫痫发作类型的操作性修订方案。此修订的目的包括认识到一些发作类型既可以是局灶起源亦可以为全面起源,允许临床在不能观察到发作起源的情况下进行发作分类,纳入某些尚不了解的发作类型,以及采用更加易懂的命名。由于现有知识不足以形成一个科学的分类方案,2016年的分类方案是在1981年和2010年分类的基础上进行的操作性(实用性)修订。新分类的变化包括:(1)'部分性'改为'局灶性';(2)起源未知的癫痫发作也可以归类;(3)知觉状态用作局灶性发作的区分因素;(4)删除'认知障碍性'、'简单部分性'、'复杂部分性'、'精神性'、'继发全面性'等术语;(5)认识到局灶性强直、阵挛、失张力、肌阵挛和癫痫性痉挛发作,这些发作也有双侧性类型;(6)增加了新的全面性发作类型:伴眼睑肌阵挛的失神发作,肌阵挛失神发作,肌阵挛-失张力发作,阵挛-强直-阵挛发作,癫痫性痉挛;癫痫性痉挛可以是局灶性、全面性或起源不明性;(7)双侧强直阵挛发作取代了继发全面性发作。新的分类方案并未进行根本性的改变,但可以使癫痫发作类型的命名有较大的灵活性和透明度。 | Robert S Fisher J Helen Cross 陈佳 王玉平 吴逊 | 2017 | 癫痫杂志2017，3，1： | 25 |
| 2 | Beyond the Pediatric end-stage liver disease system: Solutions for infants with biliary atresia requiring liver transplant显示文摘Biliary atresia(BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant, with up to one half of BA children needing a transplant by age two. In the current pediatric end-stage liver disease system, children with BA face the risk of not receiving a liver in a safe and timely manner. In this review, we discuss a number of possible solutions to help these children. We focus on two general approaches:(1) preventing/delaying need for transplantation, by optimizing the success of the Kasai operation; and(2) expediting transplantation when needed, by performing techniques other than the standard deceased-donor, whole, ABO-matched organ transplant. | Mary Elizabeth M Tessier Sanjiv Harpavat Ross W Shepherd Girish S Hiremath Mary L Brandt Amy Fisher John A Goss | 2014 | World Journal of Gastroenterology2014，20，32： | 14 |
| 3 | Direct characterization of a nonlinear photonic circuit’s wave function with laser light显示文摘Integrated photonics is a leading platform for quantum technologies including nonclassical state generation1–4,demonstration of quantum computational complexity5 and secure quantum communications6.As photonic circuits grow in complexity,full quantum tomography becomes impractical,and therefore an efficient method for their characterization7,8 is essential.Here we propose and demonstrate a fast,reliable method for reconstructing the two-photon state produced by an arbitrary quadratically nonlinear optical circuit.By establishing a rigorous correspondence between the generated quantum state and classical sum-frequency generation measurements from laser light,we overcome the limitations of previous approaches for lossy multimode devices9,10.We applied this protocol to a multi-channel nonlinear waveguide network and measured a 99.28±0.31%fidelity between classical and quantum characterization.This technique enables fast and precise evaluation of nonlinear quantum photonic networks,a crucial step towards complex,largescale,device production. | Francesco Lenzini Alexander N Poddubny James Titchener Paul Fisher Andreas Boes Sachin Kasture Ben Haylock Matteo Villa Arnan Mitchell Alexander S Solntsev Andrey A Sukhorukov Mirko Lobino | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 4 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 5 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 6 | 责任制医疗照护机构——美国的经验与教训显示文摘Hugh Alderwick与同事强调:英国国家健康体系(NHS)的政策制定者应实事求是地看待新型医疗保健模式带来的潜在收益。英格兰国家健康体系(NHS)决策圈都在谈论源自美国的一个新概念——责任制医疗照护机构(ACOs)。英格兰NHS和卫生部长认为ACO(s以及相关的责任制医疗体系)是改进NHS服务的重要途径。 | Hugh Alderwick Stephen M Shortell Adam D M Briggs Elliott S Fisher 周红霞(译) 肖月(校) | 2019 | 中国医院院长2019，0，12： | 2 |
| 7 | Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion显示文摘Apolipoprotein B (apoB ) 是很低的密度脂蛋白(VLDL ) 的主要蛋白质部件并且为这些 triglyceride (TG ) 的集会和分泌物是必要的富有的粒子。从肝的后面的版本, VLDL 在血浆被变换成低密度脂蛋白(LDL ) 并且增加了 VLDL 的生产能因此在心血管的疾病起一个有害作用。增加的证据帮助了为 dyslipidemias 的处理作为一个目标建立 VLDL 汇编。多重因素涉及合拢 apoB 蛋白质和一个分泌物能干的 VLDL 粒子的形成。没有通过的 VLDL 汇编能在 hepatocyte 开始质量控制机制为降级的那目标 apoB。ApoB 是底层因为 endoplasmic 蜂窝胃由 ubiquitin proteasome 系统并且为 autophagy 联系了降级(ERAD ) 。有效指向和 apoB 的处理是调制 VLDL 分泌物的一个调整过程并且 TG 划分。新兴的证据建议那重要重叠在这些 degradative 小径之间存在。例如,到 autophagy 和展开的蛋白质反应(UPR ) 的饭后的激活的 apoB 的调停胰岛素的指向可以采用一样的细胞的机械和规章的暗示。在为 apoB 的质量控制机制的变化影响肝的生理学和病理状态,包括胰岛素抵抗和脂肪肝。发信号的胰岛素,类脂化合物新陈代谢和肝的 UPR 可以影响 VLDL 生产,特别地在饭后的状态期间。在我们总结我们 VLDL 的当前的理解的这评论,汇编, apoB 降级,质量控制机制和这些的角色在肝生理学并且处于病理学的状态处理。 | Eric Fisher Elizabeth Lake Roger S McLeod | 2014 | The Journal of Biomedical Research2014，28，3： | 2 |
| 8 | Adverse events of upper GI endoscopy显示文摘 | Tamir Ben-Menachem G. Anton Decker Dayna S. Early Jerry Evans Robert D. Fanelli Deborah A. Fisher Laurel Fisher Norio Fukami Joo Ha Hwang Steven O. Ikenberry Rajeev Jain Terry L. Jue Khalid M. Khan Mary L. Krinsky Phyllis M. Malpas John T. Maple Ravi N. S | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 9 | C-jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid 显示文摘 | Fisher GJ Datta S Wang ZQ | 2000 | Clin Invest2000，106，5： | 1 |
| 10 | Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer显示文摘 | Anderson S Redmond CK | 1995 | N Engl J Med1995，333，： | 1 |
| 11 | Implantation and the placenta key pieces of the development puzzle 显示文摘 | CROSS J C WERB Z FISHER S J | 1994 | Science1994，5190，266： | 1 |
| 12 | Molecular determinants of response to TRAIL in killing of normal and cancer cells显示文摘 | Kim K Fisher M J Xu S Q | 2000 | Clin Cancer Res2000，6，： | 1 |
| 13 | Joint toque control by a direct feedback for industrial robots显示文摘 | LUH J Y S FISHER W D RICHARD P C P | 1995 | IEEE Trans on Aut Contl1995，64，20： | 1 |
| 14 | Cytokine enhancement of immunogenicity in chronic myeloid leukemia 显示文摘 | Coleman S Throp D Fisher J | 1997 | Leukemia1997，11，12： | 1 |
| 15 | Photic-and pattern-induced seizures: a review of the epilepsy foundation of america working group 显示文摘 | FISHER R S HARDING G ERBA G | 2005 | Epilepsia2005，46，9： | 1 |
| 16 | Image measures and their performance显示文摘 | ESKICIOGLN A M FISHER P S | 1995 | IEEE Transactions Com- munications1995，43，12： | 1 |
| 17 | Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer显示文摘 | Fisher B Anderson S Bryant J | 2002 | N Engl J Med2002，347，16： | 1 |
| 18 | Atomic-scale investiga- tion of defects, dopants, and lithium transport in the LiFePO4 oli- vine-type battery material 显示文摘 | Islam M S Driscoll D J Fisher C A J | 2005 | Chem Mater2005，17，： | 1 |
| 19 | Mechanism- based profiling of MMPs 显示文摘 | Fisher JF Mobashery S | 2010 | Methods Mol Biol2010，622，1： | 1 |
| 20 | Reduction of Wind Turbine Noise Using Optimized Airfoil and Trailing- Edge Serrations 显示文摘 | Oerlemans S Fisher M Maeder T | 2009 | AIAA Journal2009，47，： | 1 |
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