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| 1 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 2 | Short communication : Influence of microbial inoculation and co - composting material on the evolution of humic - like substances during composting of horticultural wastes 显示文摘 | Vargas - Garcia M adel Carmen Suarez - Estrella F Francisca Lopez M a Jose | 2006 | Process Biochemistry2006，41，6： | 1 |
| 3 | Multinational evidence-based recommendations for the diagnosis and management of gout: inte'ating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3c initiative显示文摘 | Francisca S Marlano A Lomto C | 2014 | Annals of the Rheumatic Dis- eases2014，73，2： | 1 |
| 4 | A validated solid - liquid extraction method for the HPLC determination of polyphenols in apple tissues Comparison with pressurised liquid extraction显示文摘 | ROSA M ALEJANDRO B EDURNE C LUIS A BLANCA G FRANCISCA V | 2005 | Talanta2005，，65： | 1 |
| 5 | Changes in riparian woods over space and time: Influence of environment and land use显示文摘 | Ferreira M T Francisca C A Nogueira C | 2005 | Forest Ecology and Management2005，212，1： | 1 |
| 6 | Harvest prediction in Algerie' loquat 显示文摘 | Hueso J Mercedes P Z Francisca A | 2007 | International Journal of Biomete- orology2007，51，： | 1 |
| 7 | Biodelignification and humification of horticultural plant residues by fungi显示文摘 | María José Lopez Maria del Carmen Vargas-García Francisca Suárez-Estrella Joaquín Moreno | 2005 | International Biodeterioration & Biodegradation2005，，1： | 1 |
| 8 | Influence of pH and ionic strengthon Cd, Cu and Pb removal from water by adsorption in Na-bentonite显示文摘 | Glatstein D A Francisca F M | 2015 | Applied Clay Science2015，18，： | 1 |
| 9 | Preparation of composites and nanoeomposites based on bentonite and poly(sodium acrylate) 显示文摘 | SANTIAG()A Francisca MUCIENTESB Antonio E OS()RIOA M6nica | 2007 | European Polymer Journal2007，43，1： | 1 |
| 10 | The Pricing of Protected Areas in Nature-Based Tourism: A Local Perspective 显示文摘 | FRANCISCA A | 2006 | Ecological Economics2006，56，2： | 1 |
| 11 | Phylogeny and temporal diversification of Calomys ( Rodentia, Sigmodontinae ) :Implications for the biogeography of an endemic genus of the open/dry biomes of South America 显示文摘 | FRANCISCA C A CIBELE R B PEDRO C E | 2007 | Mol Phylogenet Evol2007，42，： | 1 |
| 12 | Removal of immiscible contaminants from sandy soils monitored by means of dielectric measurements显示文摘 | Víctor A Rinaldi Franco M Francisca | 2006 | Journal of Environmental Engineering2006，132，8： | 1 |
| 13 | Potential usefulness of olive oil-based lipid emulsions in selected situations of home parenteral nutrition-associated liver diseases显示文摘 | Reimund JM Yves A Francisca J | 2004 | Clin Nutr2004，23，6： | 1 |
| 14 | Sub-cellular distribution of glutathione in an Arabidopsis mutant ( vtc1 ) deficient in ascorbate显示文摘 | Nieves Fernandez-García Maria C. Martí Ana Jimenez Francisca Sevilla Enrique Olmos | 2009 | Journal of Plant Physiology2009，，18： | 1 |
| 15 | Thermogravimetric study of different sewage sludges and their relationship with the nitrogen content显示文摘 | FRANCISCA G R M FONT R FULLANA A | 2005 | Journal of Analytical and Applied Pyrolysis2005，74，1： | 1 |
| 16 | Relation Between Increased Fetal Nuchal Translucency Thickness and Chromosomal Defects 显示文摘 | Karl OK Kyriaki A Francisca SM | 2006 | Obstet Gynecol2006，107，1： | 1 |
| 17 | Degradation of trimethoprim antibiotic by UVA photoelectro -Fenton process mediated by Fe (III) - carboxylate complexes 显示文摘 | Francisca C Moreira Rui A R Boaventura Enric Brillas etal | 2015 | Applied Catalysis B :Environmental2015，162，： | 1 |
| 18 | Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets显示文摘 | Octavio Aravena Bárbara Pesce Lilian Soto Natalia Orrego Francisca Sabugo Pamela Wurmann María Carmen Molina Jorge Alfaro Miguel Cuchacovich Juan Carlos Aguillón Diego Catalán | 2011 | Immunobiology2011，，12： | 1 |
| 19 | Re- lease of-Tocopherol from Poly (lactic acid) Films, and Its Ef- fect on the Oxidative Stability of Soybean Oil显示文摘 | FRANCISCA M L HERLINDA S V RAFAEL A | 2011 | Journal of Food Engineering2011，104，： | 1 |
| 20 | Addition of rosin acid during thermoplas- tic polyurethane synthesis to improve its immediate adhesion to PVC显示文摘 | Francisca Aran-Ais Ana M Torro Palau Cesar Orgiles- Barcelo A | 2005 | Int J Adhes Adhes2005，25，： | 1 |
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