|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Generalized peisach model of hysteresis (Invited) 显示文摘 | Mayergoyz I D Friedman G | 1988 | IEEE Trans on Magnetics1988，24，1： | 1 |
| 3 | Important causes of visual impairment in the world today显示文摘 | Congdon N G Friedman D S Lietman T | 2003 | JAMA2003，290，15： | 1 |
| 4 | Femtosecond laser capsulotomy显示文摘 | FRIEDMAN N J PALANKER DV SCHUELE G ANDERSEN D MARCELLINO G SEIBEL BS | 2011 | J Cataract Refract Surg2011，37，7： | 1 |
| 5 | The leukocyte count as a predictor of myocardial infarction 显示文摘 | Friedman G D Klatsky A I Siegelaub A B | 1974 | N Engl J Med1974，290，23： | 1 |
| 6 | Oxygen supply dependency can characterize septic shock显示文摘 | Friedman G De Backer D Shahla M | 1998 | Intensive Care Med1998，24，2： | 1 |
| 7 | Superparamagnetic photonic crystals显示文摘 | Xu X L Friedman G Humfeld K D Majetich S A Asher S A | 2001 | Adv Mater2001，13，： | 1 |
| 8 | Oxygen supply dependencycan characterize septic shock 显示文摘 | Friedman G Backer D Shahla M | 1998 | Intensive Care Med1998，24，： | 1 |
| 9 | Complexfuzzy 1ogic显示文摘 | Ramot D Friedman M Langholz G | 2003 | IEEE Transactions on Fuzzy System2003，11，4： | 1 |
| 10 | 24-hour history is more closely associated with vitamin A status and provides a better estimate of dietary vitamin A intake of deficient Indonesian pre- school children than a food frequenty method 显示文摘 | HUMPHEY J FRIEDMAN D NATADISASTRA G | 2000 | J Am Diet Assoc2000，100，12： | 1 |
| 11 | Alcohol and mortality 显示文摘 | Klatsky A L Armstrong M A Friedman G D | 1992 | Ann Intem Med1992，，117： | 1 |
| 12 | H2 S incorporation in coal precursors : origins of organic sulphur in coal 显示文摘 | Casagrande D J Idowu G Friedman A | 1979 | Nature1979，282，： | 1 |
| 13 | Pulmonary complications of aneurysmal subarachnoid hemorrhage 显示文摘 | Friedman J A Pichelmann M A Piepgras D G | 2003 | Neurosurgery2003，52，5： | 1 |
| 14 | Association of trypanolytic Apoll variants with kidney disease in African American 显示文摘 | ] Genovese G Friedman D J Ross MD | 2010 | Science2010，329，5993： | 1 |
| 15 | Pain tolerance: differences according to age, sex and race 显示文摘 | WOODROW K M FRIEDMAN G D SIEGELAUB A B | 1972 | Psychosom Meal1972，34，6： | 1 |
| 16 | Possible mechanisms of primary angle closure and malignant glaucoma显示文摘 | Quigley H A Friedman D S Congdon N G | 2003 | J Glaucoma2003，12，： | 1 |
| 17 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 18 | Complex fuzzy logic 显示文摘 | Ramot D Friedman M Langholz G | 2003 | IEEE Transactions on Fuzzy Systems2003，11，4： | 1 |
| 19 | Centrally controlled heart rate changes during mental practice in immersive virtual environment:A case study with a tetraplegic显示文摘 | PFURTSCHELLER G LEEB R FRIEDMAN D | 2008 | International Journal of Psychophysiology2008，68，1： | 1 |
| 20 | Insufficient duration of venous thromboembolism prophylaxis after total hip or knee replacement when compared with the time course of thromboem- bolie events findings from the Global Orthopaedie Registry显示文摘 | Warwick D Friedman RJ Agnelli G | 2007 | J Bone Joint Surg Br2007，89，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员