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您的检索式：作者名="FUKASE Koichi"
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| 1 | Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology显示文摘While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with lysine residues.The electrocyclic reaction of the 1-azatriene system,a cyclization precursor,exhibited a significant substituent effect.Asymmetric chiral piperidine synthesis and a one-pot library synthesis of pyridines on solid-supports were applied to synthesize pyridine/indole alkaloid-type natural product.Additionally,we developed lysine-based labeling and engineering of biomolecules and living cells based on the rapid 6π-azaelectrocyclization.Both labels and oligosaccharide structures were introduced efficiently and selectively into surface lysines under the mild conditions;notable effects of N-glycans on proteins and living cells were visualized for the first time by PET and noninvasive fluorescence imaging. | TANAKA Katsunori KATSUMURA Shigeo FUKASE Koichi | 2012 | Science China Chemistry2012，55，1： | 1 |
| 2 | Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology显示文摘While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with lysine residues.The electrocyclic reaction of the 1-azatriene system,a cyclization precursor,exhibited a significant substituent effect.Asymmetric chiral piperidine synthesis and a one-pot library synthesis of pyridines on solid-supports were applied to synthesize pyridine/indole alkaloid-type natural product.Additionally,we developed lysine-based labeling and engineering of biomolecules and living cells based on the rapid 6π-azaelectrocyclization.Both labels and oligosaccharide structures were introduced efficiently and selectively into surface lysines under the mild conditions;notable effects of N-glycans on proteins and living cells were visualized for the first time by PET and noninvasive fluorescence imaging. | TANAKA Katsunori KATSUMURA Shigeo FUKASE Koichi | 2012 | 中国科学:化学2012，42，2： | 0 |
| 3 | N-连接寡糖中岩藻糖α(1-6)-葡萄糖胺二糖骨架的区域及立体选择性合成显示文摘岩藻糖α(1-6)-氨基葡萄糖是N-glycans基本结构骨架中的重要组成部分,在该二糖的合成上,本研究利用兼有保护羟基、'armed activation'(武装活化)、区域和立体选择性功能的苄基,以甲基-2-O-苄基-3,4-二-O-乙酰-1-硫-β-L-硫代吡喃岩藻糖苷(2)为供体,在三氟甲磺酸甲酯(MeOTf)和2,6-二-叔-丁基-4-甲基吡啶(DTBMP)催化作用下,实现了对烯丙基-3-苄基-2-脱氧-2-(2,2,2-三氯乙氧)甲酰胺基-α-D-吡喃葡萄糖苷(3)的6-位羟基的α糖基化,从而简便有效地构建了岩藻糖α(1-6)-氨基葡萄糖胺二糖骨架(1)。该工作有望推动含岩藻糖的N-连接寡糖的构建。 | 鲍光明 TANAKA Katsunori 袁厚群 王小莺 梅天笑 FUKASE Koichi | 2013 | 北京化工大学学报(自然科学版)2013，40，3： | 0 |
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