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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction显示文摘 | Alejandro Macchia Simona Monte Fabio Pellegrini Marilena Romero Daniel Ferrante Hernán Doval Antonio D'Ettorre Aldo Pietro Maggioni Gianni Tognoni | 2008 | European Journal of Clinical Pharmacology2008，，6： | 2 |
| 3 | 2013 Ambulatory Blood Pressure Monitoring Recommendations for the Diagnosis of Adult Hypertension, Assessment of Cardiovascular and other Hypertension-associated Risk, and Attainment of Therapeutic Goals显示文摘 | Ramón C. Hermida Michael H. Smolensky Diana E. Ayala Francesco Portaluppi Juan J. Crespo Fabio Fabbian Erhard Haus Roberto Manfredini Artemio Mojón Ana Moyá Luis Pi?eiro María T. Ríos Alfonso Otero Horia Balan José R. Fernández | 2013 | Chronobiology International2013，，3： | 1 |
| 4 | The fuzzy artificial immune system:motivations,basic concepts and application to clustering and web profiling显示文摘 | Olfa N Fabio G Dipankar D | 2002 | Fuzzy system2002，1，2： | 1 |
| 5 | Inhibition of anchorage dependent cell spreading triggers apoptosis in cultured human edothelial cell显示文摘 | Fabio R Zanetti A Sironi M Polentarutti N Lanfrancone L Dejana E | 1994 | Cell Biol1994，127，3： | 1 |
| 6 | Development and testing of a 10 kA hybrid mechanical - static DC circuit breaker 显示文摘 | Luca N Fabio B Alberto F | 2011 | IEEE Transactions on Applied Superconductivity2011，21，6： | 1 |
| 7 | Visibility editing for all-frequency shadow design显示文摘 | Juraj Obert Fabio Pellacini Sumanta N Pattanaik | | 0，，04： | 1 |
| 8 | Feedback control under data rate constraints: An overview显示文摘 | Girish N Nair Fabio Fagnani Sandro Zampieri | 2007 | Proc of the IEEE2007，95，1： | 1 |
| 9 | An Empirical Analysis of Urban Form, Transport, and Global Warming显示文摘 | Grazi Fabio van den Bergh Jeroen C J M van Ommeren Jos N | 2008 | The Energy Journal2008，，4： | 1 |
| 10 | Thermal degradation of pesti- cides under oxidative conditions 显示文摘 | OSVALDA S FABIO S ALFREDO N | 2007 | J Anal Appl Pyrolysis2007，80，1： | 1 |
| 11 | In vitro models of collagen biomineralization显示文摘 | Fabio N Alexander J Eli D | 2013 | Journal of Structural Biology2013，183，： | 1 |
| 12 | Bestavailable carbon sources to enhance the via-nitritebiological nutrients removal from supernatants of anaerobicco-digestion显示文摘 | FRISON N DI FABIO S CAVINATO C | 2013 | Chemical Engineering Journal2013，215，： | 1 |
| 13 | On the relationships between copulas of order statistics and marginal distributions显示文摘 | Jorge N Fabio S | 2010 | Statistics and Probability Letters2010，80，56： | 1 |
| 14 | Study of the active phase of silver catalysts for ethylene epoxida- tion显示文摘 | Marta C N Amorim de Carvalho Fabio B Passos | 2007 | Journal of Catalysis2007，248，： | 1 |
| 15 | A review on the use of environmentally-friendly dielectric fluids in electrical discharge machining 显示文摘 | Fabio N L Ian R P | 2004 | Materials Processing Technology2004，，149： | 1 |
| 16 | Susceptibility of human pathogenic bacteria to antimicrobial peptides from sesa- me kernels显示文摘 | Fabio T C Simone M N Carlos B J | 2007 | Current Microbiology2007，55，2： | 1 |
| 17 | Electron beam welding and post-weld treatments of steels显示文摘 | Sebastiano T Fabio N Marcello D M | 1996 | Journal of Materials Science Letters1996，15，10： | 1 |
| 18 | Multi-residue analysis of pesticide residues in mangoes using solid-phase microextraction coupled to liquid chromatography and UV- Vis detection显示文摘 | Adalberto M Filho Fabio N dos Santos Pedro A de Paula Pereira | 2011 | J Sep Sci2011，34，21： | 1 |
| 19 | Development, validation and application of a method based on DI- SPME and GC-MS for determination of pesticides of different chemical groups in surface and groundwater samples 显示文摘 | Adalberto M F Fabio N S Pereira P A | 2010 | Microchemical Journal2010，96，1： | 1 |
| 20 | Abscisic Acid Connects Phytohormone Signaling with RNA Metabolic Pathways and Promotes an Antiviral Response that Is Evaded by a Self- Controlled RNA Virus显示文摘A complex network of cellular receptors,RNA targeting pathways,and small-molecule signaling provides robust plant immunity and tolerance to viruses.To maximize their fitness,viruses must evolve control mechanisms to balance host immune evasion and plant-damaging effects.The genus Potyvirus comprises plant viruses characterized by RNA genomes that encode large polyproteins led by the P1 protease.A P1 autoinhibitory domain controls polyprotein processing,the release of a downstream functional RNAsilencing suppressor,and viral replication.Here,we show that P1Pro,a plum pox virus clone that lacks the P1 autoinhibitory domain,triggers complex reprogramming of the host transcriptome and high levels of abscisic acid(ABA)accumulation.A meta-analysis highlighted ABA connections with host pathways known to control RNA stability,turnover,maturation,and translation.Transcriptomic changes triggered by P1Pro infection or ABA showed similarities in host RNA abundance and diversity.Genetic and hormone treatment assays showed that ABA promotes plant resistance to potyviral infection.Finally,quantitative mathematical modeling of viral replication in the presence of defense pathways supported self-control of polyprotein processing kinetics as a viral mechanism that attenuates the magnitude of the host antiviral response.Overall,our findings indicate that ABA is an active player in plant antiviral immunity,which is nonetheless evaded by a self-controlled RNA virus. | Fabio Pasin Hongying Shan Beatriz García Maren Müller David San León Márta Ludman David H.Fresno Károly Fátyol Sergi Munné-Bosch Guillermo Rodrigo Juan Antonio García | 2020 | Plant Communications2020，1，5： | 1 |
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