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| 1 | Broad Specificity of SR (Serine?Arginine) Proteins in the Regulation of Alternative Splicing of Pre-Messenger RNA显示文摘 | Cyril F Bourgeois Fabrice Lejeune James Stévenin | 2004 | Progress in Nucleic Acid Research and Molecular Biology2004，，： | 1 |
| 2 | Single Processing Center Models for Human Dicer and Bacterial RNase Ill显示文摘 | Zhang H Fabrice A K Witold F E A | 2004 | Ce112004，118，1： | 1 |
| 3 | A sinkhole resilient proto- col for wireless sensor networks: performance and security analysis 显示文摘 | Fabrice L F Antonis P Aline C V | 2012 | Computer Communications2012，35，2： | 1 |
| 4 | Identificttion and cloning of αβ-Cell-Specific zinc transporter, Zn T-8, localized into insulin 显示文摘 | Fabric C Severine D Alaini F | 2004 | Secretory Granules Diabetes2004，53，： | 1 |
| 5 | Airway humidification with a heat and mois- ture exchanger in mechanically ventilated neonates 显示文摘 | Mikaila F Fabrice M | 2007 | Intensive Care Med2007，33，： | 1 |
| 6 | Follow - up of couples with primary infertility in an ART programme using frozen donor semen 显示文摘 | G Fabrice F Florence M Henri | 2002 | Human Reproduction2002，17，6： | 1 |
| 7 | DETERMINATE and LATE FLOWERING are two TERMINAL FLOWER1/CENTRORADIALIS homologs that control two distinct phases of flowering initiation and development in pea显示文摘 | FABRICE F JULIE M | 2003 | The Plant Cell2003，15，： | 1 |
| 8 | Characterisation of PZT thin film micro-actuators using a silicon micro-force sen- sor显示文摘 | Fabrice F D Stephen A W Graham E | 2007 | Sensors and Actuators A: Physical2007，133，1： | 1 |
| 9 | Camptothecin-binding site in human serum albumin and protein transformations induced by drug binding显示文摘 | Fabrice F Anatoli I Maurice B | 1997 | FEBS Letters1997，411，23： | 1 |
| 10 | Identification and cloning of a β-Cell-Specific zinc transporter,ZnT-8,localized into insulin显示文摘 | Fabrice C Severine D Alaini F | 2004 | Secretory Granules Diabetes2004，53，： | 1 |
| 11 | Photometer Measurement of Polydisperse Aerosols 显示文摘 | Gorner P Bemer D FabriCs F | 1995 | Journal of Aerosol Science1995，26，： | 1 |
| 12 | Cure kinetics and morphology of blends of epoxy resin with poly (ether ether ketone) containing pendant tertiary butyl groups 显示文摘 | BEJOY F GEERT V P FABRICE P | 2003 | Polymer2003，44，： | 1 |
| 13 | Cure kinetics and morphology of blends of epoxy resin with poly (ether ether ketone) containing pendant tertiary butyl groups 显示文摘 | Bejoy F Geert V P Fabrice P Gabriel G V Rao L Ramaswamy R Thomas S | 2003 | Polymer2003，44，： | 1 |
| 14 | Oxytocin during myomeetomy: A randomized study 显示文摘 | Aubert A Isabelle R Fabrice F | 2005 | Gynecol Reprod Biol2005，118，2： | 1 |
| 15 | EUS-FNA predicts 5-year survival in pancreatic endocrine tumors显示文摘 | Fátima A.F. Figueiredo Marc Giovannini Genevieve Monges Erwan Bories Christian Pesenti Fabrice Caillol Jean Robert Delpero | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 16 | Protein-Lipid Interactions at the Air/Water Interface 显示文摘 | Mitaben D L Fabrice B Richard A F | 2005 | Physical Chemistry Chemical Physics2005，7，19： | 1 |
| 17 | Overview of Identification Methods of Mechanical Parameters Based on Full-field Measurements显示文摘 | Stéphane Avril Marc Bonnet Anne-Sophie Bretelle Michel Grédiac Fran?ois Hild Patrick Ienny Félix Latourte Didier Lemosse Stéphane Pagano Emmanuel Pagnacco Fabrice Pierron | 2008 | Experimental Mechanics2008，，4： | 1 |
| 18 | In vivo cardiac pacemaker function of differentiated human mesenchymal stem cells from adipose tissue transplanted into porcine hearts显示文摘BACKGROUND Mesenchymal stem cells(MSC)modified by gene transfer to express cardiac pacemaker channels such as HCN2 or HCN4 were shown to elicit pacemaker function after intracardiac transplantation in experimental animal models.Human MSC derived from adipose tissue(haMSC)differentiate into cells with pacemaker properties in vitro,but little is known about their behavior after intracardiac transplantation.AIM To investigate whether haMSC elicit biological pacemaker function in vivo after transplantation into pig hearts.METHODS haMSC under native conditions(nhaMSC)or after pre-conditioning by medium differentiation(dhaMSC)(n=6 pigs each,5×106 cells/animal)were injected into the porcine left ventricular free wall.Animals receiving PBS injection served as controls(n=6).Four weeks later,total atrioventricular(AV)-block was induced by radiofrequency catheter ablation,and electronic pacemaker devices were implanted for backup stimulation and heart rate monitoring.Ventricular rate and rhythm of pigs were evaluated during a follow-up of 15 d post ablation by 12-lead-ECG with heart rate assessment,24-h continuous rate monitoring recorded by electronic pacemaker,assessment of escape recovery time,and pharmacological challenge to address catecholaminergic rate response.Finally,hearts were analyzed by histological and immunohistochemical investigations.RESULTS In vivo transplantation of dhaMSC into the left ventricular free wall of pigs elicited spontaneous and regular rhythms that were pace-mapped to ventricular injection sites(mean heart rate 72.2±3.6 bpm;n=6)after experimental total AV block.Ventricular rhythms were stably detected over a 15-d period and were sensitive to catecholaminergic stimulation(mean maximum heart rate 131.0±6.2 bpm;n=6;P<0.001).Pigs,which received nhaMSC or PBS presented significantly lower ventricular rates(mean heart rates 47.2±2.5 bpm and 37.4±3.2 bpm,respectively;n=6 each;P<0.001)and exhibited little sensitivity towards catecholaminergic stimulation(mean maximum heart rates 76.4±3.1 bpm and 60.5±3.1 bpm,respectively;n=6 each;P<0.05).Histological and immunohistochemical evaluation of hearts treated with dhaMSC revealed local clusters of transplanted cells at the injection sites that lacked macrophage or lymphocyte infiltrations or tumor formation.Intense fluorescence signals at these sites indicated membrane expression of HCN4 and other pacemaker-specific proteins involved in cardiac automaticity and impulse propagation.CONCLUSION dhaMSC transplanted into pig left ventricles sustainably induced rate-responsive ventricular pacemaker activity after in vivo engraftment for four weeks.The data suggest that pre-conditioned MSC may further differentiate along a pacemakerrelated lineage after myocardial integration and may establish superior pacemaker properties in vivo. | Fabrice F Darche Rasmus Rivinius Ann-Kathrin Rahm Eva Köllensperger Uwe Leimer Günter Germann Miriam Reiss Michael Koenen Hugo A Katus Dierk Thomas Patrick A Schweizer | 2020 | World Journal of Stem Cells2020，12，10： | 0 |
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