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| 1 | A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome显示文摘AIM:To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome(MetS).METHODS:Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination(AP)consisting of berberine,policosanol and red yeast rice,in a prospective,double-blind,placebo-controlled study.Evaluations were performed at baseline and after 18 wk of treatment.The homeostasis model assessment of insulin resistance(HOMAIR)index was the primary outcome measure.Secondary endpoints included lipid panel,blood glucose and insulin fasting,after a standard mixed meal and after an oral glucose tolerance test(OGTT),ow-mediated dilation(FMD),and waist circumference.RESULTS:Fifty nine patients completed the study,2 withdrew because of adverse effects.After 18 wk there was a signif icant reduction in the HOMA-IR index in the AP group compared with placebo(ΔHOMA respectively-0.6 ± 1.2 vs 0.4 ± 1.9;P < 0.05).Total and low density lipoprotein cholesterol also significantly decreased in the treatment arm compared with placebo(Δlow density lipoprotein cholesterol-0.82 ± 0.68 vs-0.13 ± 0.55 mmol/L;P < 0.001),while triglycerides,high density lipoprotein cholesterol,and the OGTT were not affected.In addition,there were significant reductions in blood glucose and insulin after the standard mixed meal,as well as an increase in FMD(ΔFMD 1.9 ± 4.2 vs 0 ± 1.9 %;P < 0.05)and a significant reduction in arterial systolic blood pressure in the AP arm.CONCLUSION:This short-term study shows that AP has relevant beneficial effects on insulin resistance and many other components of MetS. | Flora Affuso Valentina Mercurio Antonio Ruvolo Concetta Pirozzi Filomena Micillo Guido Carlomagno Fabrizia Grieco Serafino Fazio | 2012 | World Journal of Cardiology2012，4，3： | 7 |
| 2 | Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients显示文摘 | Giuseppe Marazzi Luca Cacciotti Francesco Pelliccia Luigi Iaia Maurizio Volterrani Giuseppe Caminiti Barbara Sposato Rosalba Massaro Fabrizia Grieco Giuseppe Rosano | 2011 | Advances in Therapy2011，，12： | 2 |
| 3 | Isolated limb infusion chemotherapy with or without hemofiltration for recurrent limb melanoma显示文摘AIM: To better define the efficacy and the safety of intra-arterial infusion performed with or without hemofiltration for recurrent limb melanoma. METHODS: Patients with the following characteristics were included in the study: recurrent limb melanoma not indicated for surgical resection, measurable disease in the extremity, > 18 years, performances status(Eastern Cooperative Oncology Group) was 0-1 and life expectancy of at least 6 mo. Twenty nine consecutive patients were enrolled in the study. Patients underwent fluoroscopic placement of angiographic arterial and venous catheters to infuse the drug in the artery [isolated limb infusion(ILI)], and to stop the out flow(venous). Melphalan was rapidly infused into the isolated limb via the arterial catheter after the inflation of venous balloon catheter. Then the circulation of the limb was completely blocked with a pneumatic cuff at the root of the limb. Haemofiltration(HF) was available only in the main center, and was performed with an extracorporeal perfusion system, in order to reduce high systemic toxic peaks of drug.RESULTS: Thirty seven ILI were done in 29 cases(31 ILI-HF and 6 ILI) between 2001 and 2014 at Ancona and Pesaro Hospitals, Italy. Clinical outcomes were monitored 30 d after treatment. Eleven patients(38%) received infusion of melphalan alone, 7(24%) melphalan associated to mitomicin C and 7(24%) melphalan associated to cisplatin, the remaining 4 were treated with cisplatin, melphalan and epirubicin or cisplatin and mitomicin C. The overall response rate was 66%, in particular, 3 patients(10%) were complete responders and 16(56%) were partial responders; whereas 7 patients(24%) had stable disease, and 3(10%) showed progressive disease. Limb toxicity was assessed adopting Wieberdink scale, with evidence of 90% of low grade(I and II) toxicity.CONCLUSION: ILI-HF and ILI are effective and safe treatments for recurrent non-resectable limb melanoma. They present evidence of favorable clinical benefit and is effective in delaying progression. | Sara Cecchini Donatella Sarti Stefano Ricci Ludovico Delle Vergini Manuela Sallei Stefano Serresi Giuseppe Ricotti Luca Mulazzani Fabrizia Lattanzio Giammaria Fiorentini | 2015 | World Journal of Clinical Oncology2015，6，4： | 2 |
| 4 | Impaired uptake of 5 hydroxytryptamine platelet in essential hypertension: Clinical relevance显示文摘 | Natalia Fetkovska Alfred Pletscher Fabrizia Ferracin Ruth Amstein Fritz R. Buhler | 1990 | Cardiovascular Drugs and Therapy1990，，1： | 1 |
| 5 | Oxidative stress and homocysteine in coronary artery disease显示文摘 | Giuliani N Fabrizia B | 2001 | Clin Chem2001，47，： | 1 |
| 6 | Analysis of phenolic compounds and radical scavenging activity of Echinacea spp.显示文摘 | Federica Pellati Stefania Benvenuti Lara Magro Michele Melegari Fabrizia Soragni | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，，2： | 1 |
| 7 | Comparison of Microlife BP A200 Plus and Omron M6 Blood Pressure Monitors to Detect Atrial Fibrillation in Hypertensive Patients显示文摘 | Giuseppe Marazzi Ferdinando Iellamo Maurizio Volterrani Mauro Lombardo Francesco Pelliccia Daniela Righi Fabrizia Grieco Luca Cacciotti Luigi Iaia Giuseppe Caminiti Giuseppe Rosano | 2012 | Advances in Therapy2012，，1： | 1 |
| 8 | Onset of Resin Mi- cro - cracks in Unidirectional Glass Fiber Laminates with Integrat- ed SHM Sensors -Experimental显示文摘 | Fabrizia Ghezzo Yi Huang Sia Nemat Nasser | 2009 | Structural Health Monitoring2009，8，6： | 1 |
| 9 | Evidence that low doses of taxol enhance the functional transactivatory properties of p53 on p21 war promoter in MCF-7 breast cancer cells显示文摘 | Luisa P M Francesca G Fabrizia M | 2006 | Federation of European Biochemical Socie- ties2006，580，9： | 1 |
| 10 | O - H…X H - bond显示文摘 | FABRIZIA GREPIONI DARIO BRAGA | 1998 | Organometa llics1998，7，： | 1 |
| 11 | Chronic subdural hematoma results of a homogeneous series of 159 patients operated on by residents显示文摘 | Gastone P Fabrizia C Homere M | 2004 | Neurol India2004，52，4： | 1 |
| 12 | Meanings of sexual intercourse for Italian adolescents显示文摘 | Fabrizia Giannotta Silvia Ciairano Rob Spruijt Donna Spruijt-Metz | 2008 | Journal of Adolescence2008，，2： | 1 |
| 13 | Magnetic Coupling in End-to-End Azido-Bridged Copper and Nickel Binuclear Complexes : A Theoretical Study 显示文摘 | Fabrizia Fabrizide Biani Eliseo Ruiz Joan Cano | 2000 | Inorg Chem2000，39，15： | 1 |
| 14 | Effects of AZT on cellular iron homeostasis显示文摘 | Argante Bozzi Fabrizia Brisdelli Anna M. D’Alessandro Gabriele D’Andrea Anna R. Lizzi Andrea C. Rinaldi Arduino Oratore | 2004 | BioMetals2004，，4： | 1 |
| 15 | Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele显示文摘 | Claudia Rendeli Emanuele Ausili Mario Castorina Daniela Antuzzi Fabrizia Tabacco Massimo Caldarelli | 2006 | Child’s Nervous System2006，，10： | 1 |
| 16 | The relevance of anatomic and hemodynamic factors to a classification of cerebral arteriovenous malformations 显示文摘 | Alberto Pasqualin Giovanni Barone Fabrizia Cioffi | 1991 | Neurosurgery1991，28，： | 1 |
| 17 | Health technology assessment and patients' rights: assess versus access显示文摘 | FRAN OIS ran ois H YANN L C FABRIZIA B | 2011 | Pharmaceuticals policy and law2011，，： | 1 |
| 18 | Prevalence of orthodontic treatment need in southern Italian schoolchildren 显示文摘 | Letizia Peril Caterina Masueei Fabrizia Ferro | 2010 | European Journal of Orthodontics2010，，32： | 1 |
| 19 | Oxidative stress and homocysteine in coronary artery disease显示文摘 | VIVIANA C GIULIANA N FABRIZIA B | 2001 | Clin Chem2001，47，： | 1 |
| 20 | Association of chlorophyll a / c 2 complexes to photosystem I and photosystem II in the cryptophyte Rhodomonas CS24显示文摘 | Sami Kere?che Roman Kou?il Gert T. Oostergetel Fabrizia Fusetti Egbert J. Boekema Alexander B. Doust Chantal D. van der Weij-de Wit Jan P. Dekker | 2008 | BBA - Bioenergetics2008，，9： | 1 |
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