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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | A classification of ecological boundaries显示文摘 | Strayer D L Power M E Fagan W F | 2003 | BioScience2003，53，8： | 1 |
| 3 | Design and Code Inspections to Reduce Errors in Program Development 显示文摘 | FAGAN M E | 1976 | IBM System Journal1976，15，3： | 1 |
| 4 | Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer' s disease显示文摘 | HARTMAN R E SHAH A FAGAN A M | 2006 | Neurobiology of Disease2006，24，： | 1 |
| 5 | A critical role for critical habitat in the recovery planning process ? Not yet显示文摘 | Hoekstra J M Fagan W F Bradley J E | 2002 | Ecological Applications2002，12，： | 1 |
| 6 | Design and Code Inspections to Reduce Errors in Program Development显示文摘 | M E Fagan | 1976 | IBM Systems Journal1976，15，3： | 1 |
| 7 | Mercury biogeochemistry in the Idrija River,Slovenia,from above the mine into the Gulf of Trieste显示文摘 | Hines M E Horvat M Faganeli J | 2000 | Environmental Research2000，83，2： | 1 |
| 8 | Generalized entering coefficients:A criterion for foam stability against oil in porous media 显示文摘 | Bergeron V Fagan M E Radke C J | 1993 | Langmuir1993，9，7： | 1 |
| 9 | First principles study of 1, 2-dichlorobenzene adsorption on metallic carbon nanotubes 显示文摘 | Fagan S B Girao E C Filho J M | 2006 | International Journal of Quantum Chemistry2006，106，13： | 1 |
| 10 | Microbial mercury transformations in marine, estuarine and freshwater sediment downstream of the Idrija mercury mine, Slovenia显示文摘 | Hines M E Faganeli J Adatto I | 2006 | Applied Geochemistry2006，21，11： | 1 |
| 11 | Mercury biogeochemistry in the Idrija river, slovenia, from above the mine into the gulf of trieste 显示文摘 | Hines M E Horvat M Faganeli J | 2000 | Environmental Research2000，83，2： | 1 |
| 12 | Exploiting the inter-strain divergence of Fusarium oxysporum formicrobial bioprocessing of lignocellulose to bioethanol 显示文摘 | ALI SS KHAN M FAGAN B MULLINS E DOOHAN FM | 2012 | AMBExpress2012，152，1： | 1 |
| 13 | Self-Assembly of ordered nanowires in biological suspensions of single-wall car- bon nanotubes显示文摘 | Hobbie E K Fagan J A Becket M L | 2009 | ACS Nano2009，27，： | 1 |
| 14 | L-Arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension显示文摘 | Fagan J M Rex S E Hayes-Licitra | 1999 | Biochem Biophys Res Commun1999，254，： | 1 |
| 15 | Design and code inspections to reduce errors in program development 显示文摘 | Fagan M E | 1976 | IBM Systems Journal1976，15，3： | 1 |
| 16 | Mercury in lagoons:An overview of the importance of the link between geochemistry and biology显示文摘 | Faganeli J Hines M E Covelli S | 2012 | Estuarine Coastal and Shelf Science2012，113，： | 1 |
| 17 | Device closure of seeundum atrial septal defects in children <15 kg: complication rates and indications for referral显示文摘 | BARTAKIAN S FAGAN T E SCHAFFER M S | 2012 | JACC Cardiovasc Interv2012，5，11： | 1 |
| 18 | Generalized entering coefficients: A criterion for foam stability against oil in porous media 显示文摘 | BERGERON V FAGAN M E RADKE C J | 1993 | Langmuir1993，9，7： | 1 |
| 19 | Exploiting the inter-strain divergence of Fusarium oxysporum formicrobial bioprocessing of lignocellulose to bioethanol 显示文摘 | ALI SS KHAN M FAGAN B MULLINS E DOOHAN FM | 2012 | AMBExpress2012，152，1： | 1 |
| 20 | Ab initiostudy of 2,3 ,7 ,8-tetrachlorinated dibenzo-p-dioxin adsorptionon single wail carbon nanotubes I>8978'2011 显示文摘 | FAGAN S B SANTOS E J G’FILHO J M | 2007 | ChemicalPhysics Letters2007，437，123： | 1 |
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