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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Analysis of torque ripple due to phase commutation in brush- less DC machines 显示文摘 | CARLSON R LAJOIE-MAZENC M FAGUNDES J C D S | 1992 | IEEE transactions on industry applica- tion1992，28，3： | 1 |
| 3 | Analysis of torque ripple due to phase commutation in brushless DC machines 显示文摘 | Carlson R Lajoic M M Fagundes J C | 1992 | IEEE Transactions on Industry Applications1992，28，3： | 1 |
| 4 | Phosphoinositide- 3 kinase γ activity contributes to sepsis and organ damage by altering neutrophil recruitment显示文摘 | Martin E L Souza D G Fagundes C T | 2010 | Am J Respir Crit Care Med2010，182，6： | 1 |
| 5 | Analysis oftorque ripple due to phase commutation in bmshless dc ma-chines 显示文摘 | Carlson R Lajoie - Mazenc M Fagunde J C D S | 1992 | IEEE Transactions on Industrial Applications1992，28，3： | 1 |
| 6 | Direct AC-AC Converters Using Commercial Power Modules Applied to Voltage Restorers 显示文摘 | SOEIRO T B PETRY C A FAGUNDES J C | 2011 | IEEE Trans on Industrial Electronics2011，58，1： | 1 |
| 7 | Effect of antifungal hydroxypropyl methyl cellulose-beeswax edible coatings on gray mold development and quality attributes of cold-stored cherry tomato fruit显示文摘 | FAGUNDES C PALOU L MONTEIRO A R | 2014 | Postharvest Biology and Technology2014，92，1： | 1 |
| 8 | Hepatorenal syndrome: a severe,but treatable, cause of kidney failure in cirrhosis显示文摘 | Fagundes C Ginfes P | 2012 | Am J Kidney Dis2012，59，： | 1 |
| 9 | Antifungal activity of food additives in vitro and as ingredients of hydroxypropyl methylcellulose-lipid edible coatings against Botrytis cinerea and Alternaria altemata on cherry tomato fruit显示文摘 | FAGUNDES C PEREZ-GAGO M B MONTEIRO A R | 2013 | International Journal ofFood Microbiology2013，166，3： | 1 |
| 10 | Child maltreatment and breast cancer survivors:Social support makes a difference for quality of life, fatigue and cancer stress 显示文摘 | Fagundes C P Lindgren M E Shapiro C L | 2012 | European Journal of Cancer2012，48，5： | 1 |
| 11 | Acate kidneyinjury is an early predictor of mortality for patients with clcoholic hepatitis显示文摘 | Altamiramo J Fagundes C Dominguez M | 2012 | Clin Castroenterol Hepatol2012，10，： | 1 |
| 12 | Acute kidney injury (AKI)negatively impacts short-term survival in patients with alcoholic hepatitis: implications for therapy显示文摘 | ALTAMIRANO J BATALLER R FAGUNDES C | 2010 | Hepatology2010，52，1： | 1 |
| 13 | Analysis of torque ripple due to phase commutation in brushless DC machines显示文摘 | Carlson R Lajoie M M Fagundes J C | 1992 | IEEE Transactions on Industry Applications1992，28，3： | 1 |
| 14 | Analysis of torque tipple due to phase commutation in brushless DC machines显示文摘 | CARLSON R LAJOIE-MAZENC M FAGUNDES J C S | 1992 | IEEE Trans Ind Applications1992，28，3： | 1 |
| 15 | Adsorption of Cr(VI) using Fe-crosslinked chitosan complex (Ch-Fe)显示文摘 | Zimmermann A C Mecabo A Fagundes T | 2010 | Journal ofHazardous Materials2010，179，1： | 1 |
| 16 | Anti- fungal activity of food additives in vitro and as ingredients of hydroxypropyl methylcellulose-lipid edible coatings a- gainst Botrytis cinerea and Alternaria alternate on cherry tomato fruit显示文摘 | Fagundes C P:rez-Gago M B Monteiro A R | 2013 | International Journal of Food Microbiolo- gy2013，166，3： | 1 |
| 17 | Effects of repeated extracorporeal shock wave on kidney apoptosis of normal and diabetic rat显示文摘 | Kira V M Fagundes D J Bandeira C O | 2008 | International Braz J Urol2008，34，1： | 1 |
| 18 | Urinary neu- trophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney func- tion in cirrhosis 显示文摘 | Fagundes C P6pin MN Guevara M | 2012 | J Hepatol2012，57，2： | 1 |
| 19 | Lower Subjective Social Status Exaggerates Interleukin 6 Re- sponses to a Laboratory Stressor 显示文摘 | DERRY H M FAGUNDES C P ANDRIDGE R | 2013 | Psychoneuroendocrinology2013，38，11： | 1 |
| 20 | Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach 显示文摘 | Fagundes C LeRoy A Karuga M | 2015 | J Pets Med2015，5，3： | 1 |
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