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| 1 | 免疫治疗相关垂体炎的临床表现、治疗和生物学展望显示文摘免疫治疗的进展已经改变了转移性黑素瘤的治疗方式,并在其他恶性肿瘤的治疗方面产生了令人鼓舞的结果。免疫不良事件(immunerelated adverse events,IRAEs)是免疫制剂的副作用,其形式多种多样的,包括多发性的内分泌疾病。 | 陈彦 alexander faje | 2017 | 福建医药杂志2017，39，5： | 3 |
| 2 | Representing Model Uncertainty by Multi-Stochastic Physics Approaches in the GRAPES Ensemble显示文摘To represent model uncertainties more comprehensively,a stochastically perturbed parameterization(SPP)scheme consisting of temporally and spatially varying perturbations of 18 parameters in the microphysics,convection,boundary layer,and surface layer parameterization schemes,as well as the stochastically perturbed parameterization tendencies(SPPT)scheme,and the stochastic kinetic energy backscatter(SKEB)scheme,is applied in the Global and Regional Assimilation and Prediction Enhanced System-Regional Ensemble Prediction System(GRAPES-REPS)to evaluate and compare the general performance of various combinations of multiple stochastic physics schemes.Six experiments are performed for a summer month(1-30 June 2015)over China and multiple verification metrics are used.The results show that:(1)All stochastic experiments outperform the control(CTL)experiment,and all combinations of stochastic parameterization schemes perform better than the single SPP scheme,indicating that stochastic methods can effectively improve the forecast skill,and combinations of multiple stochastic parameterization schemes can better represent model uncertainties;(2)The combination of all three stochastic physics schemes(SPP,SPPT,and SKEB)outperforms any other combination of two schemes in precipitation forecasting and surface and upper-air verification to better represent the model uncertainties and improve the forecast skill;(3)Combining SKEB with SPP and/or SPPT results in a notable increase in the spread and reduction in outliers for the upper-air wind speed.SKEB directly perturbs the wind field and therefore its addition will greatly impact the upper-air wind-speed fields,and it contributes most to the improvement in spread and outliers for wind;(4)The introduction of SPP has a positive added value,and does not lead to large changes in the evolution of the kinetic energy(KE)spectrum at any wavelength;(5)The introduction of SPPT and SKEB would cause a 5%-10%and 30%-80%change in the KE of mesoscale systems,and all three stochastic schemes(SPP,SPPT,and SKEB)mainly affect the KE of mesoscale systems.This study indicates the potential of combining multiple stochastic physics schemes and lays a foundation for the future development and design of regional and global ensembles. | Zhizhen XU Jing CHEN Zheng JIN Hongqi LI Fajing CHEN | 2020 | Advances in Atmospheric Sciences2020，37，4： | 2 |
| 3 | Radiation-induced phosphorylation of Chkl at S345 is associated with p53- dependent cell cycle arrest pathways显示文摘 | TIAN H FAJE A T LEE S L | 2002 | Neoplasia2002，4，2： | 1 |
| 4 | A unified verification system for operational models from R egional M eteorological Centres of C hina M eteorological A dministration显示文摘 | Jing Chen Yu Wang Li Li Bin Zhao Fajing Chen Yinglin Li Yingjie Cui | 2013 | Met Apps2013，，2： | 1 |
| 5 | Radiation-induced phosphorylation of CHK1 at S345 is associated with P53-dependent cell cycle arrest pathways显示文摘 | Lee SL Tian Hui Faje AT | 2002 | Neoplasis2002，4，2： | 1 |
| 6 | Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways显示文摘 | Lee SL Tian Hui Faje AT | 2002 | Neoplasia2002，4，2： | 1 |
| 7 | Radiation-induced phosphory- lation of Chkl at S345 is associated with p53-dependent cell cycle arrest pathways 显示文摘 | Tian H Faje AT Lee SL et ol | 2002 | Neoplasia2002，4，2： | 1 |
| 8 | Central diabetes insipidus:a previously unreported side effect of temozolomide显示文摘 | Faje AT Nachtigall L Wexler D | 2013 | J Clin Endocrinol Metab2013，98，10： | 1 |
| 9 | Radiation -induced phos- phorylation of Chkl at $345 is associated with p53 - de- pendent cell cycle arrest pathways 显示文摘 | Tian H Faje A T Lee SL | 2002 | Neoplasia2002，4，2： | 1 |
| 10 | Central diabetes insipidus:a previously unreported side effect of temozolomide显示文摘 | Faje AT Nachtigall L Wexler D | 2013 | J Clin Endocrinol Metab2013，98，10： | 1 |
| 11 | Body composition and skeletal health: too heavy Too thin 显示文摘 | Faje A Klibanski A | 2012 | Curr Osteoporos Rep2012，10，3： | 1 |
| 12 | Central Diabetes Insipidus: A Previously Unreported Side Effect of Temozolomide显示文摘 | Alexander T. Faje Lisa Nachtigall Deborah Wexler Karen K. Miller Anne Klibanski Hideo Makimura | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，： | 1 |
| 13 | An Initial Perturbation Method for the Multiscale Singular Vector in Global Ensemble Prediction显示文摘Ensemble prediction is widely used to represent the uncertainty of single deterministic Numerical Weather Prediction(NWP) caused by errors in initial conditions(ICs). The traditional Singular Vector(SV) initial perturbation method tends only to capture synoptic scale initial uncertainty rather than mesoscale uncertainty in global ensemble prediction. To address this issue, a multiscale SV initial perturbation method based on the China Meteorological Administration Global Ensemble Prediction System(CMA-GEPS) is proposed to quantify multiscale initial uncertainty. The multiscale SV initial perturbation approach entails calculating multiscale SVs at different resolutions with multiple linearized physical processes to capture fast-growing perturbations from mesoscale to synoptic scale in target areas and combining these SVs by using a Gaussian sampling method with amplitude coefficients to generate initial perturbations. Following that, the energy norm,energy spectrum, and structure of multiscale SVs and their impact on GEPS are analyzed based on a batch experiment in different seasons. The results show that the multiscale SV initial perturbations can possess more energy and capture more mesoscale uncertainties than the traditional single-SV method. Meanwhile, multiscale SV initial perturbations can reflect the strongest dynamical instability in target areas. Their performances in global ensemble prediction when compared to single-scale SVs are shown to(i) improve the relationship between the ensemble spread and the root-mean-square error and(ii) provide a better probability forecast skill for atmospheric circulation during the late forecast period and for short-to medium-range precipitation. This study provides scientific evidence and application foundations for the design and development of a multiscale SV initial perturbation method for the GEPS. | Xin LIU Jing CHEN Yongzhu LIU Zhenhua HUO Zhizhen XU Fajing CHEN Jing WANG Yanan MA Yumeng HAN | 2024 | Advances in Atmospheric Sciences2024，41，3： | 0 |
| 14 | Tectonic and Geodynamic Setting of Oil and Gas Basins in China显示文摘About 26 sedimentary basins bearing oil and gas are developed in China. They can be classified into two main types , extensional basins and foreland basins . The former are chiefly distributed in the eastern part and the latter in the central and northwestern parts of the country . The present paper discusses the structural characteristics of these basins , including subsidence history , thermal history and structural style and kinematics . Combined with tectonic setting analysis of geophysical data and eruptive rocks , the geodynamic setting of the basins is established , and the formation mechanism of the basins is deduced to have been related to the subduction of the Izanagi and west Pacific plates and the closing of the Tethys ocean. | Chen Fajing Wang Xinwen Zhang Guangya Cao Shoulian Luo ChuanrongDepartment of Geology and Energy Resources, China University of Geosciences, Beijing 100083 | 1995 | Journal of Earth Science1995，14，2： | 0 |
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