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| 1 | Methionine adenosyltransferases in liver cancer显示文摘Methionine adenosyltransferases(MATs)are essential enzymes for life as they produce S-adenosylmethionine(SAMe),the biological methyl donor required for a plethora of reactions within the cell.Mammalian systems express two genes,MAT1A and MAT2A,which encode for MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,respectively.A third gene MAT2B,encodes a regulatory subunit known as MATβwhich controls the activity of MATα2.MAT1A,which is mainly expressed in hepatocytes,maintains the differentiated state of these cells,whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver(e.g.,hepatic stellate and Kupffer cells).The biosynthesis of SAMe is impaired in patients with chronic liver disease and liver cancer due to decreased expression and inactivation of MATα1.A switch from MAT1A to MAT2A/MAT2B occurs in multiple liver diseases and during liver growth and dedifferentiation,but this change in the expression pattern of MATs results in reduced hepatic SAMe level.Decades of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular carcinoma(HCC)to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver carcinogenesis.An increasing volume of work indicates that MATs have SAMe-independent functions,distinct interactomes and multiple subcellular localizations.Here we aim to provide an overview of MAT biology including genes,isoenzymes and their regulation to provide the context for understanding consequences of their dysregulation.We will highlight recent breakthroughs in the field and underscore the importance of MAT’s in liver tumorigenesis as well as their potential as targets for cancer therapy. | Ben Murray Lucia Barbier-Torres Wei Fan JoséM Mato Shelly C Lu | 2019 | World Journal of Gastroenterology2019，25，31： | 10 |
| 2 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 3 | Hydrogen storage in single- walled carbon nanotubes at room temperature显示文摘 | Liu C Fan Y Y Liu M | 1999 | Science1999，286，5442： | 2 |
| 4 | Headspace solid phase microextraction and gas chromatography-olfactometry dilution analysis of young and aged Chinese'Yanghe Daqu'liquors显示文摘 | Fan W L Qian M C | 2005 | Journal of Agricultural and Food Chemistry2005，53，20： | 2 |
| 5 | The kinetics of producing sulfate-based complex coagulant from fly ash 显示文摘 | Fan M Brown R C Van Leeuwen J | 2003 | Chemical Engineering and Processing2003，42，12： | 1 |
| 6 | Characterization of aroma compounds in apple cider using solvent-assisted flavor evaporation and headspace solid-phase microextraction显示文摘 | XU Y FAN W L QIAN M C | 2007 | J Agric Food Chem2007，55，8： | 1 |
| 7 | Ikappa-Balpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation显示文摘 | Fan C Li Q Zhang Y Liu X Luo M Abbott D | 2004 | J Clin Invest2004，113，： | 1 |
| 8 | Glibert,Effects of light on nitrogen and carbon uptake during a Prorocentrum minimum bloom显示文摘 | PATRICIA M | 2005 | Harmful Algae2005，，4： | 1 |
| 9 | Time-dependent fundamental solutions for homogeneous diffusion problems显示文摘 | Young D L Tsai C C Murugesan K Fan C M Chen C W | 2004 | Engineering Analysis with Boundary Elements2004，28，： | 1 |
| 10 | Expression of midkine in the early stage of carcinogenesis in human colorectal cancer显示文摘 | Ye C Qi M Fan QW | 1999 | Br J Cancer1999，79，1： | 1 |
| 11 | Biologically active phenols from Saussurea medusa显示文摘 | FAN C Q YUE J M | 2003 | Bioorg Med Chem2003，11，5： | 1 |
| 12 | Geochronology and geochemistry of the Hegenshan ophiofitic complex: Implications for late-stage tectonic evolution of the Inner Mongolia-Daxinganling Orogenic Belt, China显示文摘 | Miao L C Fan W M Liu D Y | 2008 | Journal of Asian Each Sciences2008，32，： | 1 |
| 13 | Plant structured textile fabrics 显示文摘 | SARKAR M FAN J T SZETO Y C | 2007 | Materials Letters2007，61，： | 1 |
| 14 | Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity显示文摘 | Yuan Q Fan G C Dong M | 2007 | Circulation2007，115，3： | 1 |
| 15 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | Headspace solid phase microextraction and gas chromatography-olfactometry dilution analysis of young and aged Chineso 'Yanghe Daqu' liquors显示文摘 | FAN W QIAN M C | 2005 | J Agric Food Chem2005，53，20： | 1 |
| 17 | Characterization of the affinity for nitrogen,uptake kinetics,and environmental relationships for Prorocentrum minimum in natural blooms and laboratory cultures显示文摘 | FAN C GLIBERT P M BURKHOLDER J M | 2003 | Harmful Algae2003，2，： | 1 |
| 18 | The Micro Structuml Evolution of An Al-Zn-Mg-Cu Alloy during Homogenization显示文摘 | X G Fan D M Jiang Q C Meng | 2006 | Materials Letters2006，60，12： | 1 |
| 19 | Image restoration combing a total variational filter and a fourth-order filter显示文摘 | LI F SHEN C M FAN J S | 2007 | Journal of Visual Communication and Image Representation2007，18，4： | 1 |
| 20 | Urbanization from below:the growth of towns in Jiangsu,China显示文摘 | Ma L J C Fan M | 1994 | Urban Studies1994，31，10： | 1 |
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