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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Acute respiratory symp- toms in adults in general practice显示文摘 | Hong C Y Lin R T 'Fan E S | 2004 | Faro Pract2004，21，3： | 1 |
| 3 | A causal C-A mutation in the second exon of GS3 highly associated with rlee grain length and validated as a functional marker 显示文摘 | Fan C Yu S Wang C | 2009 | Theoretical Applied Genetics2009，118，： | 1 |
| 4 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 5 | Giardia Lamblia,Hapoid genome size determined by pulsed field gel electrophoresis is less than 12Mb显示文摘 | Fan J B S H Korman C R Canter | 1991 | Nucleic Acids Res1991，19，： | 1 |
| 6 | On the origin of the high coarsening resistance of Ω plates in Al-Cu-Mg-Ag alloys显示文摘 | HUTCHINSON C R FAN X PENNYCOOK S J SHIFLET G J | 2001 | Acta Materialia2001，49，： | 1 |
| 7 | Security constrained multi-objective generation dispatch using bicriterion global optimization显示文摘 | Chang C S Wong K P Fan B | 1995 | IEE Proceedings of Generation Transmission and Distribution1995，142，4： | 1 |
| 8 | Immobiliza- tion of Candida krusei cells producing phytase in algi- nate gel beads: an application of the preparation of myo-inositol phosphates显示文摘 | QUAN C S FAN S D OHTA Y | 2003 | Appl Microbiol Biotech- nol2003，62，1： | 1 |
| 9 | Image restoration combing a total variational filter and a fourth-order filter显示文摘 | LI F SHEN C M FAN J S | 2007 | Journal of Visual Communication and Image Representation2007，18，4： | 1 |
| 10 | The molecular portraits of breast tumors are conserved across microarray platforms 显示文摘 | HU Z FAN C OH D S | 2006 | BMC Ge- nomics2006，7，： | 1 |
| 11 | Characterization of hot deformation behavior of a new near beta titanium alloy: Ti-7333 显示文摘 | FAN J K KOU H C LAI M J TANG B CHANG H LI J S | 2013 | Materials & Design2013，49，： | 1 |
| 12 | Demonstration of Near- Infrared Negative -Index Materials显示文摘 | Zhang S Fan W Panoiu N C | 2005 | Physics2005，4，05： | 1 |
| 13 | The method of fundamental solutions for 2D and 3D Stokes problems显示文摘 | Young D L Jane S J Fan C M Murugesan K Tsai C C | 2006 | Journal of Computational Physics2006，211，： | 1 |
| 14 | Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma 显示文摘 | Poon R T Lau C P Ho J W Yu W C Fan S T Wong J | 2003 | Clin Cancer Res2003，9，： | 1 |
| 15 | Synthesis and Thermal Decomposition Kinetics of Th(IV) Complex with Unsymmetrical Sehiff Base Ligand显示文摘 | FAN Y H BI C F LIU S Q | 2006 | Journal of Radioanalytical and Nuclear Chemistry2006，，267： | 1 |
| 16 | Time course of the MAPK and P13 - kinase response within 24 h of skeletal muscle overload 显示文摘 | Carlson C J Fan Z Gordon S E | 2001 | J Appl Physiol2001，91，5： | 1 |
| 17 | Flow work exchanger显示文摘 | CHENG C Y CHENG S W FAN L T | 1967 | AIChE J1967，13，： | 1 |
| 18 | Factors affecting conversion of laparoscopic cholecytectomy to open surgery显示文摘 | Liu C L Fan S T Lai ESC | 1996 | Arch1996，131，1： | 1 |
| 19 | Optimization of Systems Reliability显示文摘 | FAN L T WANG C S | 1967 | IEEE Transaction on Reliability1967，16，4： | 1 |
| 20 | A Petri netbased method for compatibility analysis and composition of Web services in business process execution language显示文摘 | TAN W FAN Y S ZHOU M C | 2009 | IEEE Transactions of Automation Science and Engineering2009，6，1： | 1 |
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