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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 3 | 白细胞介素8/β连环蛋白介导成釉细胞瘤的上皮-间充质转化显示文摘Zhang J,Wang Y,Fan C,et al.Interleukin-8/β-catenin mediates epithelial-mesenchymal transition in ameloblastoma.Oral Dis,2019 Aug.目的:上皮-间充质转化(EMT)在牙发育和肿瘤侵袭中发挥重要作用。 | 赵泽亮 Zhang J Wang Y Fan C | 2019 | 中国口腔颌面外科杂志2019，17，5： | 6 |
| 4 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 5 | Ordered, nanostructured tin-based oxides/carbon composite as the negative-elec- trode material for lithium-ion batteries 显示文摘 | Fan J Wang T Yu C | 2004 | Advanced Maerials2004，16，16： | 1 |
| 6 | Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells显示文摘 | Lei J Wendt C H Fan D | 2007 | Am J Physiol Lung Cell Mol Physiol2007，292，1： | 1 |
| 7 | The kinetics of producing sulfate-based complex coagulant from fly ash 显示文摘 | Fan M Brown R C Van Leeuwen J | 2003 | Chemical Engineering and Processing2003，42，12： | 1 |
| 8 | Mesotunnels on the silica wall of ordered SBA-15 to generate three-dimensional large-pore mesoporous networks显示文摘 | Yu C Wang L | 2001 | J Am Chem SCc2001，123，12： | 1 |
| 9 | Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential显示文摘 | FAN H VILLEGAS C WRIGHT J A | 1996 | Proc Natl Acad Sci USA1996，93，14： | 1 |
| 10 | Development of a Powder Warming Compacting Machine with an Electrical Heating System显示文摘 | Lung C Y Fan K C Mou J | 2002 | Powder Technology2002，127，： | 1 |
| 11 | The Effects of State-structured Population Growth Model显示文摘 | Cao Y Fan J Gard T C | 1992 | Nonlin Appl1992，16，2： | 1 |
| 12 | Biologically active phenols from Saussurea medusa显示文摘 | FAN C Q YUE J M | 2003 | Bioorg Med Chem2003，11，5： | 1 |
| 13 | Plant structured textile fabrics 显示文摘 | SARKAR M FAN J T SZETO Y C | 2007 | Materials Letters2007，61，： | 1 |
| 14 | Extracellular ATP is involved in the initiation of pollen germination and tube growth in Picea meyeri 显示文摘 | ZHOU J FAN C LIU K | 2015 | Trees2015，29，2： | 1 |
| 15 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | Elasto-plastic stability of sin- gle-layer reticulated domes with initial curvature of mem- bers显示文摘 | FAN F YAN J C CAO Z G | 2012 | Thin-Walled Structures2012，60，： | 1 |
| 17 | Giardia Lamblia,Hapoid genome size determined by pulsed field gel electrophoresis is less than 12Mb显示文摘 | Fan J B S H Korman C R Canter | 1991 | Nucleic Acids Res1991，19，： | 1 |
| 18 | On the origin of the high coarsening resistance of Ω plates in Al-Cu-Mg-Ag alloys显示文摘 | HUTCHINSON C R FAN X PENNYCOOK S J SHIFLET G J | 2001 | Acta Materialia2001，49，： | 1 |
| 19 | Characterization of the affinity for nitrogen,uptake kinetics,and environmental relationships for Prorocentrum minimum in natural blooms and laboratory cultures显示文摘 | FAN C GLIBERT P M BURKHOLDER J M | 2003 | Harmful Algae2003，2，： | 1 |
| 20 | A Nitric oxide biosensor based on the multi-assembly of hemoglobin/ montmorillonite/polyvinyl alcohol at a pyrolytic graphite electrode 显示文摘 | PANG J FAN C LIU X | 2003 | Biosensors and Bioelectronics2003，19，5： | 1 |
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